ID   GLUC_ALLMI              Reviewed;          29 AA.
AC   P68954; P01276;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 47.
DE   RecName: Full=Glucagon;
GN   Name=GCG;
OS   Alligator mississippiensis (American alligator).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC   Alligator.
OX   NCBI_TaxID=8496;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=6146554; DOI=10.1016/0016-6480(84)90135-7;
RA   Lance V., Hamilton J.W., Rouse J.B., Kimmel J.R., Pollock H.G.;
RT   "Isolation and characterization of reptilian insulin, glucagon, and
RT   pancreatic polypeptide: complete amino acid sequence of alligator
RT   (Alligator mississippiensis) insulin and pancreatic polypeptide.";
RL   Gen. Comp. Endocrinol. 55:112-124(1984).
CC   -!- FUNCTION: Glucagon plays a key role in glucose metabolism and
CC       homeostasis. Regulates blood glucose by increasing gluconeogenesis and
CC       decreasing glycolysis.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- INDUCTION: Produced in the A cells of the islets of Langerhans in
CC       response to a drop in blood sugar concentration.
CC   -!- SIMILARITY: Belongs to the glucagon family. {ECO:0000305}.
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DR   AlphaFoldDB; P68954; -.
DR   SMR; P68954; -.
DR   STRING; 8496.XP_006278056.1; -.
DR   eggNOG; ENOG502RYPR; Eukaryota.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR015550; Glucagon.
DR   InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR   PANTHER; PTHR11418; PTHR11418; 1.
DR   Pfam; PF00123; Hormone_2; 1.
DR   PRINTS; PR00275; GLUCAGON.
DR   SMART; SM00070; GLUCA; 1.
DR   PROSITE; PS00260; GLUCAGON; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Hormone; Secreted.
FT   PEPTIDE         1..29
FT                   /note="Glucagon"
FT                   /id="PRO_0000043921"
SQ   SEQUENCE   29 AA;  3470 MW;  04D474D35C73F027 CRC64;
     HSQGTFTSDY SKYLDTRRAQ DFVQWLMST