ID   GLUC_AMICA              Reviewed;          75 AA.
AC   P33528;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   10-FEB-2021, entry version 71.
DE   RecName: Full=Pro-glucagon;
DE   Contains:
DE     RecName: Full=Glucagon;
DE   Contains:
DE     RecName: Full=Glucagon-like peptide;
DE   Flags: Precursor; Fragments;
GN   Name=gcg;
OS   Amia calva (Bowfin).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Holostei; Amiiformes; Amiidae; Amia.
OX   NCBI_TaxID=7924;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Pancreas;
RX   PubMed=8240302; DOI=10.1042/bj2950857;
RA   Conlon J.M., Youson J.H., Mommsen T.P.;
RT   "Structure and biological activity of glucagon and glucagon-like peptide
RT   from a primitive bony fish, the bowfin (Amia calva).";
RL   Biochem. J. 295:857-861(1993).
CC   -!- FUNCTION: [Glucagon]: Plays a key role in glucose metabolism and
CC       homeostasis. Regulates blood glucose by increasing gluconeogenesis and
CC       decreasing glycolysis. {ECO:0000250|UniProtKB:P01275}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the glucagon family. {ECO:0000305}.
CC   -!- CAUTION: X's in the sequence were included by homology with other
CC       sequences. {ECO:0000305}.
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DR   PIR; S39018; S39018.
DR   PIR; S39019; S39019.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR015550; Glucagon.
DR   InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR   PANTHER; PTHR11418; PTHR11418; 1.
DR   Pfam; PF00123; Hormone_2; 1.
DR   PRINTS; PR00275; GLUCAGON.
DR   SMART; SM00070; GLUCA; 2.
DR   PROSITE; PS00260; GLUCAGON; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Hormone; Secreted.
FT   PEPTIDE         1..29
FT                   /note="Glucagon"
FT                   /evidence="ECO:0000269|PubMed:8240302"
FT                   /id="PRO_0000011323"
FT   PEPTIDE         45..75
FT                   /note="Glucagon-like peptide"
FT                   /evidence="ECO:0000269|PubMed:8240302"
FT                   /id="PRO_0000011324"
SQ   SEQUENCE   75 AA;  8861 MW;  2C526C78ECDCA2F0 CRC64;
     HSQGTFTNDY SKYMDTRRAQ DFVQWLMSTX XXXXXXXXXX XXXXYADAPY ISDVYSYLQD
     QVAKKWLKSG QDRRE