GLUC_ANAPL
ID GLUC_ANAPL Reviewed; 29 AA.
AC P68952; P01276;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 25-MAY-2022, entry version 52.
DE RecName: Full=Glucagon;
GN Name=GCG;
OS Anas platyrhynchos (Mallard) (Anas boschas).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8839;
RN [1]
RP PROTEIN SEQUENCE, AND CRYSTALLIZATION.
RX PubMed=4636745; DOI=10.1016/0014-5793(72)80595-7;
RA Sundby F., Frandsen E.K., Thomsen J., Kristiansen K., Brunfeldt K.;
RT "Crystallization and amino acid sequence of duck glucagon.";
RL FEBS Lett. 26:289-293(1972).
CC -!- FUNCTION: Glucagon plays a key role in glucose metabolism and
CC homeostasis. Regulates blood glucose by increasing gluconeogenesis and
CC decreasing glycolysis.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- INDUCTION: Produced in the A cells of the islets of Langerhans in
CC response to a drop in blood sugar concentration.
CC -!- SIMILARITY: Belongs to the glucagon family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR PIR; A01542; GCDK.
DR AlphaFoldDB; P68952; -.
DR SMR; P68952; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR InterPro; IPR015550; Glucagon.
DR InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR PANTHER; PTHR11418; PTHR11418; 1.
DR Pfam; PF00123; Hormone_2; 1.
DR PRINTS; PR00275; GLUCAGON.
DR SMART; SM00070; GLUCA; 1.
DR PROSITE; PS00260; GLUCAGON; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Hormone; Secreted.
FT PEPTIDE 1..29
FT /note="Glucagon"
FT /id="PRO_0000043922"
SQ SEQUENCE 29 AA; 3470 MW; 04D474D35C73F027 CRC64;
HSQGTFTSDY SKYLDTRRAQ DFVQWLMST