ID   GLUC_ATRSP              Reviewed;          78 AA.
AC   P09566;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 2.
DT   10-FEB-2021, entry version 80.
DE   RecName: Full=Pro-glucagon;
DE   Contains:
DE     RecName: Full=Oxyntomodulin;
DE     AltName: Full=Glucagon-36;
DE   Contains:
DE     RecName: Full=Glucagon;
DE   Contains:
DE     RecName: Full=Glucagon-like peptide;
DE   Flags: Precursor; Fragment;
GN   Name=gcg;
OS   Atractosteus spatula (Alligator gar) (Lepisosteus spatula).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC   Atractosteus.
OX   NCBI_TaxID=7917;
RN   [1]
RP   PROTEIN SEQUENCE OF 1-36 AND 45-78.
RC   TISSUE=Pancreas;
RX   PubMed=3282974; DOI=10.1016/0016-6480(88)90062-7;
RA   Pollock H.G., Kimmel J.R., Ebner K.E., Hamilton J.W., Rouse J.B., Lance V.,
RA   Rawitch A.B.;
RT   "Isolation of alligator gar (Lepisosteus spatula) glucagon, oxyntomodulin,
RT   and glucagon-like peptide: amino acid sequences of oxyntomodulin and
RT   glucagon-like peptide.";
RL   Gen. Comp. Endocrinol. 69:133-140(1988).
RN   [2]
RP   PRELIMINARY PROTEIN SEQUENCE OF 1-29.
RC   TISSUE=Pancreas;
RX   PubMed=3311873; DOI=10.1016/0016-6480(87)90192-4;
RA   Pollock H.G., Kimmel J.R., Hamilton J.W., Rouse J.B., Ebner K.E., Lance V.,
RA   Rawitch A.B.;
RT   "Isolation and structures of alligator gar (Lepisosteus spatula) insulin
RT   and pancreatic polypeptide.";
RL   Gen. Comp. Endocrinol. 67:375-382(1987).
CC   -!- FUNCTION: [Glucagon]: Plays a key role in glucose metabolism and
CC       homeostasis. Regulates blood glucose by increasing gluconeogenesis and
CC       decreasing glycolysis. {ECO:0000250|UniProtKB:P01275}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- INDUCTION: Produced in the A cells of the islets of Langerhans in
CC       response to a drop in blood sugar concentration.
CC   -!- MISCELLANEOUS: X's in the sequence were included by homology with
CC       American goosefish sequences.
CC   -!- SIMILARITY: Belongs to the glucagon family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   PIR; S06339; GCGXA.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR015550; Glucagon.
DR   InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR   PANTHER; PTHR11418; PTHR11418; 1.
DR   Pfam; PF00123; Hormone_2; 2.
DR   PRINTS; PR00275; GLUCAGON.
DR   SMART; SM00070; GLUCA; 2.
DR   PROSITE; PS00260; GLUCAGON; 2.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Hormone; Secreted.
FT   PEPTIDE         1..36
FT                   /note="Oxyntomodulin"
FT                   /evidence="ECO:0000269|PubMed:3282974"
FT                   /id="PRO_0000011340"
FT   PEPTIDE         1..29
FT                   /note="Glucagon"
FT                   /evidence="ECO:0000269|PubMed:3282974"
FT                   /id="PRO_0000011341"
FT   PEPTIDE         45..78
FT                   /note="Glucagon-like peptide"
FT                   /evidence="ECO:0000269|PubMed:3282974"
FT                   /id="PRO_0000011342"
SQ   SEQUENCE   78 AA;  9000 MW;  30106496271594E0 CRC64;
     HSQGTFTNDY SKYLDTRRAQ DFVQWLMSTK RSGGITXXXX XXXXHADGTY TSDVSSYLQD
     QAAKKFVTWL KQGQDRRE