ID   GLUC_CARAU              Reviewed;         121 AA.
AC   P79695;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Pro-glucagon;
DE   Contains:
DE     RecName: Full=Glicentin-related polypeptide;
DE              Short=GRPP;
DE   Contains:
DE     RecName: Full=Glucagon;
DE   Contains:
DE     RecName: Full=Glucagon-like peptide;
DE   Flags: Precursor;
GN   Name=gcg;
OS   Carassius auratus (Goldfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Carassius.
OX   NCBI_TaxID=7957;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   DOI=10.1023/A:1007793705131;
RA   Yuen T.T.H., Mok P.Y., Chow B.K.C.;
RT   "Molecular cloning of a cDNA encoding proglucagon from goldfish, Carassius
RT   auratus.";
RL   Fish Physiol. Biochem. 17:223-230(1997).
CC   -!- FUNCTION: [Glucagon]: Plays a key role in glucose metabolism and
CC       homeostasis. Regulates blood glucose by increasing gluconeogenesis and
CC       decreasing glycolysis. {ECO:0000250|UniProtKB:P01275}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the glucagon family. {ECO:0000305}.
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DR   EMBL; U65528; AAB39563.1; -; mRNA.
DR   AlphaFoldDB; P79695; -.
DR   SMR; P79695; -.
DR   Proteomes; UP000515129; Genome assembly.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR015550; Glucagon.
DR   InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR   PANTHER; PTHR11418; PTHR11418; 1.
DR   Pfam; PF00123; Hormone_2; 2.
DR   PRINTS; PR00275; GLUCAGON.
DR   SMART; SM00070; GLUCA; 2.
DR   PROSITE; PS00260; GLUCAGON; 2.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Hormone; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         22..47
FT                   /note="Glicentin-related polypeptide"
FT                   /evidence="ECO:0000250|UniProtKB:P09686"
FT                   /id="PRO_0000011334"
FT   PEPTIDE         50..78
FT                   /note="Glucagon"
FT                   /evidence="ECO:0000250|UniProtKB:P01275"
FT                   /id="PRO_0000011335"
FT   PROPEP          80..85
FT                   /evidence="ECO:0000250|UniProtKB:P01275"
FT                   /id="PRO_0000011336"
FT   PEPTIDE         88..121
FT                   /note="Glucagon-like peptide"
FT                   /evidence="ECO:0000250|UniProtKB:P01275"
FT                   /id="PRO_0000011337"
FT   SITE            49..50
FT                   /note="Cleavage; by PCSK2"
FT                   /evidence="ECO:0000250"
FT   SITE            87..88
FT                   /note="Cleavage; by PCSK1"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   121 AA;  13527 MW;  5C1D4BEC1D26B9C6 CRC64;
     MKGAQYLAGL LLLLFVQNSI CVPLQDYHTS TETVEGLLAR GQGFTTAKRH SEGTFSNDYS
     KYLETRRAQD FVEWLMNSKS NGGSAKRHAE GTYTSDISSF LRDQAAQNFV AWLKSGQPKQ
     E