ID   GLUC_CHICH              Reviewed;          29 AA.
AC   P31297;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Glucagon;
GN   Name=GCG;
OS   Chinchilla chinchilla (Short-tailed chinchilla) (Chinchilla brevicaudata).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha;
OC   Chinchillidae; Chinchilla.
OX   NCBI_TaxID=10152;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=2235678; DOI=10.1016/0196-9781(90)90180-d;
RA   Eng J., Kleinman W.A., Chu L.S.;
RT   "Purification of peptide hormones from chinchilla pancreas by chemical
RT   assay.";
RL   Peptides 11:683-685(1990).
CC   -!- FUNCTION: Glucagon plays a key role in glucose metabolism and
CC       homeostasis. Regulates blood glucose by increasing gluconeogenesis and
CC       decreasing glycolysis.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- INDUCTION: Produced in the A cells of the islets of Langerhans in
CC       response to a drop in blood sugar concentration.
CC   -!- SIMILARITY: Belongs to the glucagon family. {ECO:0000305}.
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DR   PIR; A60413; GCCB.
DR   AlphaFoldDB; P31297; -.
DR   SMR; P31297; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007188; P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway; IEA:UniProt.
DR   InterPro; IPR015550; Glucagon.
DR   InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR   PANTHER; PTHR11418; PTHR11418; 1.
DR   Pfam; PF00123; Hormone_2; 1.
DR   PRINTS; PR00275; GLUCAGON.
DR   SMART; SM00070; GLUCA; 1.
DR   PROSITE; PS00260; GLUCAGON; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Hormone; Phosphoprotein; Secreted.
FT   PEPTIDE         1..29
FT                   /note="Glucagon"
FT                   /id="PRO_0000043917"
FT   MOD_RES         2
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P55095"
SQ   SEQUENCE   29 AA;  3478 MW;  19ECF4DABB752B27 CRC64;
     HSQGTFTSDY SKHLDSRYAQ EFVQWLMNT