GLUC_CORGL
ID GLUC_CORGL Reviewed; 228 AA.
AC P48244;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 26-JUL-2002, sequence version 2.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Glutamate transport system permease protein GluC {ECO:0000305};
DE AltName: Full=Glutamate uptake system protein GluC {ECO:0000305};
GN Name=gluC {ECO:0000303|PubMed:7868586}; OrderedLocusNames=Cgl1952, cg2138;
OS Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 /
OS JCM 1318 / LMG 3730 / NCIMB 10025).
OC Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC Corynebacterium.
OX NCBI_TaxID=196627;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBUNIT, AND DISRUPTION
RP PHENOTYPE.
RC STRAIN=ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB
RC 10025;
RX PubMed=7868586; DOI=10.1128/jb.177.5.1152-1158.1995;
RA Kronemeyer W., Peekhaus N., Kraemer R., Sahm H., Eggeling L.;
RT "Structure of the gluABCD cluster encoding the glutamate uptake system of
RT Corynebacterium glutamicum.";
RL J. Bacteriol. 177:1152-1158(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB
RC 10025;
RX PubMed=12743753; DOI=10.1007/s00253-003-1328-1;
RA Ikeda M., Nakagawa S.;
RT "The Corynebacterium glutamicum genome: features and impacts on
RT biotechnological processes.";
RL Appl. Microbiol. Biotechnol. 62:99-109(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB
RC 10025;
RX PubMed=12948626; DOI=10.1016/s0168-1656(03)00154-8;
RA Kalinowski J., Bathe B., Bartels D., Bischoff N., Bott M., Burkovski A.,
RA Dusch N., Eggeling L., Eikmanns B.J., Gaigalat L., Goesmann A.,
RA Hartmann M., Huthmacher K., Kraemer R., Linke B., McHardy A.C., Meyer F.,
RA Moeckel B., Pfefferle W., Puehler A., Rey D.A., Rueckert C., Rupp O.,
RA Sahm H., Wendisch V.F., Wiegraebe I., Tauch A.;
RT "The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its
RT impact on the production of L-aspartate-derived amino acids and vitamins.";
RL J. Biotechnol. 104:5-25(2003).
CC -!- FUNCTION: Part of the ABC transporter complex GluABCD involved in
CC glutamate uptake. Probably responsible for the translocation of the
CC substrate across the membrane. {ECO:0000269|PubMed:7868586}.
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (GluA),
CC two transmembrane proteins (GluC and GluD) and a solute-binding protein
CC (GluB). {ECO:0000305|PubMed:7868586}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- DISRUPTION PHENOTYPE: Deletion of the gluABCD cluster almost abolishes
CC glutamate uptake activity. {ECO:0000269|PubMed:7868586}.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. HisMQ subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X81191; CAA57062.1; -; Genomic_DNA.
DR EMBL; BA000036; BAB99345.1; -; Genomic_DNA.
DR EMBL; BX927153; CAF20293.1; -; Genomic_DNA.
DR RefSeq; NP_601159.1; NC_003450.3.
DR RefSeq; WP_011014780.1; NC_006958.1.
DR AlphaFoldDB; P48244; -.
DR SMR; P48244; -.
DR STRING; 196627.cg2138; -.
DR TCDB; 3.A.1.3.9; the atp-binding cassette (abc) superfamily.
DR KEGG; cgb:cg2138; -.
DR KEGG; cgl:Cgl1952; -.
DR PATRIC; fig|196627.13.peg.1890; -.
DR eggNOG; COG0765; Bacteria.
DR HOGENOM; CLU_019602_1_0_11; -.
DR OMA; WQSMKLV; -.
DR Proteomes; UP000000582; Chromosome.
DR GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR CDD; cd06261; TM_PBP2; 1.
DR Gene3D; 1.10.3720.10; -; 1.
DR InterPro; IPR010065; AA_ABC_transptr_permease_3TM.
DR InterPro; IPR043429; ArtM/GltK/GlnP/TcyL/YhdX-like.
DR InterPro; IPR000515; MetI-like.
DR InterPro; IPR035906; MetI-like_sf.
DR PANTHER; PTHR30614; PTHR30614; 1.
DR Pfam; PF00528; BPD_transp_1; 1.
DR SUPFAM; SSF161098; SSF161098; 1.
DR TIGRFAMs; TIGR01726; HEQRo_perm_3TM; 1.
DR PROSITE; PS50928; ABC_TM1; 1.
PE 1: Evidence at protein level;
KW Amino-acid transport; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..228
FT /note="Glutamate transport system permease protein GluC"
FT /id="PRO_0000060041"
FT TRANSMEM 16..36
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 64..84
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 145..165
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..215
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 16..217
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT CONFLICT 211..228
FT /note="LPMGLGLGKLSERLAVKK -> CLWALAWANSLSVWR (in Ref. 1;
FT CAA57062)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 228 AA; 24469 MW; CD33B2A31AB37C17 CRC64;
MSTLWADLGP SLLPAFWVTI KLTIYSAIGA MIFGTILTTM RVSPVKILRT LSTAYINTVR
NTPLTLVVLF CSFGLYQNLG LTLAGRESST FLVDNNFRLA VLGFILYTST FVAESLRSGI
NTVHFGQAEA ARSLGLGFGA TFRSIIFPQA VRAAIVPLGN TLIALTKNTT IASVIGVGEA
SLLMKATIEN HANMLFVVFA IFAVGFMILT LPMGLGLGKL SERLAVKK
