ID   GLUC_HYDCO              Reviewed;          36 AA.
AC   P09682;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Glucagon;
GN   Name=gcg;
OS   Hydrolagus colliei (Spotted ratfish) (Chimaera colliei).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Holocephali; Chimaeriformes; Chimaeridae; Hydrolagus.
OX   NCBI_TaxID=7873;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Pancreas;
RX   PubMed=3311036; DOI=10.1042/bj2450851;
RA   Conlon J.M., Dafgaard E., Falkmer S., Thim L.;
RT   "A glucagon-like peptide, structurally related to mammalian oxyntomodulin,
RT   from the pancreas of a holocephalan fish, Hydrolagus colliei.";
RL   Biochem. J. 245:851-855(1987).
CC   -!- FUNCTION: Promotes hydrolysis of glycogen and lipids, and raises the
CC       blood sugar level.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Produced by the X-cells of the islets of pancreas.
CC   -!- SIMILARITY: Belongs to the glucagon family. {ECO:0000305}.
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DR   PIR; A27885; GCFI.
DR   AlphaFoldDB; P09682; -.
DR   SMR; P09682; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   InterPro; IPR015550; Glucagon.
DR   InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR   PANTHER; PTHR11418; PTHR11418; 1.
DR   Pfam; PF00123; Hormone_2; 1.
DR   PRINTS; PR00275; GLUCAGON.
DR   SMART; SM00070; GLUCA; 1.
DR   PROSITE; PS00260; GLUCAGON; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Secreted.
FT   PEPTIDE         1..36
FT                   /note="Glucagon"
FT                   /id="PRO_0000044744"
SQ   SEQUENCE   36 AA;  4236 MW;  66F0464E52D0212F CRC64;
     HTDGIFSSDY SKYLDNRRTK DFVQWLLSTK RNGANT