ID   GLUC_ICTPU              Reviewed;          71 AA.
AC   P04093;
DT   01-NOV-1986, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 2.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Pro-glucagon;
DE   Contains:
DE     RecName: Full=Glucagon;
DE   Contains:
DE     RecName: Full=Glucagon-like peptide;
DE   Flags: Precursor; Fragment;
GN   Name=gcg;
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Pancreas;
RX   PubMed=3030323; DOI=10.1016/0006-291x(87)90633-4;
RA   Hoosein N.M., Mahrenholz A.M., Andrews P.C., Gurd R.S.;
RT   "Biological activities of catfish glucagon and glucagon-like peptide.";
RL   Biochem. Biophys. Res. Commun. 143:87-92(1987).
RN   [2]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Pancreas;
RX   PubMed=3838546; DOI=10.1016/s0021-9258(18)89208-0;
RA   Andrews P.C., Ronner P.;
RT   "Isolation and structures of glucagon and glucagon-like peptide from
RT   catfish pancreas.";
RL   J. Biol. Chem. 260:3910-3914(1985).
CC   -!- FUNCTION: [Glucagon]: Plays a key role in glucose metabolism and
CC       homeostasis. Regulates blood glucose by increasing gluconeogenesis and
CC       decreasing glycolysis. {ECO:0000250|UniProtKB:P01275}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- INDUCTION: Produced in the A cells of the islets of Langerhans in
CC       response to a drop in blood sugar concentration.
CC   -!- MISCELLANEOUS: X's in the sequence were included by homology with
CC       American goosefish sequences.
CC   -!- SIMILARITY: Belongs to the glucagon family. {ECO:0000305}.
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DR   PIR; A05166; GCIDC.
DR   Proteomes; UP000221080; Genome assembly.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR015550; Glucagon.
DR   InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR   PANTHER; PTHR11418; PTHR11418; 1.
DR   Pfam; PF00123; Hormone_2; 2.
DR   PRINTS; PR00275; GLUCAGON.
DR   SMART; SM00070; GLUCA; 2.
DR   PROSITE; PS00260; GLUCAGON; 2.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Hormone; Secreted.
FT   PEPTIDE         1..29
FT                   /note="Glucagon"
FT                   /evidence="ECO:0000269|PubMed:3030323,
FT                   ECO:0000269|PubMed:3838546"
FT                   /id="PRO_0000011338"
FT   PEPTIDE         38..71
FT                   /note="Glucagon-like peptide"
FT                   /evidence="ECO:0000269|PubMed:3030323,
FT                   ECO:0000269|PubMed:3838546"
FT                   /id="PRO_0000011339"
FT   CONFLICT        53
FT                   /note="E -> D (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   NON_TER         1
FT   NON_TER         71
SQ   SEQUENCE   71 AA;  8183 MW;  24688E79AD981A8F CRC64;
     HSEGTFSNDY SKYLETRRAQ DFVQWLMNSX XXXXXXXHAD GTYTSDVSSY LQEQAAKDFI
     TWLKSGQPKP E