ID   GLUC_LAMFL              Reviewed;          29 AA.
AC   Q9PRQ9;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Glucagon;
GN   Name=gcg;
OS   Lampetra fluviatilis (European river lamprey) (Petromyzon fluviatilis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC   Hyperoartia; Petromyzontiformes; Petromyzontidae; Lampetra.
OX   NCBI_TaxID=7748;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Small intestine;
RX   PubMed=8575665; DOI=10.1006/gcen.1995.1138;
RA   Conlon J.M., Bondareva V., Rusakov Y., Plisetskaya E.M., Mynarcik D.C.,
RA   Whittaker J.;
RT   "Characterization of insulin, glucagon, and somatostatin from the river
RT   lamprey, Lampetra fluviatilis.";
RL   Gen. Comp. Endocrinol. 100:96-105(1995).
CC   -!- FUNCTION: Glucagon plays a key role in glucose metabolism and
CC       homeostasis. Regulates blood glucose by increasing gluconeogenesis and
CC       decreasing glycolysis.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- INDUCTION: Produced in the A cells of the islets of Langerhans in
CC       response to a drop in blood sugar concentration.
CC   -!- SIMILARITY: Belongs to the glucagon family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; Q9PRQ9; -.
DR   SMR; Q9PRQ9; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR   Pfam; PF00123; Hormone_2; 1.
DR   PRINTS; PR00275; GLUCAGON.
DR   SMART; SM00070; GLUCA; 1.
DR   PROSITE; PS00260; GLUCAGON; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Hormone; Secreted.
FT   PEPTIDE         1..29
FT                   /note="Glucagon"
FT                   /id="PRO_0000043926"
SQ   SEQUENCE   29 AA;  3398 MW;  03A901D08C5EAB27 CRC64;
     HSQGSFTSDY SKYLDSKQAK DFVIWLMNT