ID   GLUC_LITCT              Reviewed;         103 AA.
AC   P15438; P15439; P15440;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 2.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Pro-glucagon;
DE   Contains:
DE     RecName: Full=Glucagon;
DE   Contains:
DE     RecName: Full=Oxyntomodulin;
DE     AltName: Full=Glucagon-36;
DE   Contains:
DE     RecName: Full=Glucagon-like peptide 1;
DE   Contains:
DE     RecName: Full=Glucagon-like peptide 2;
DE   Flags: Precursor; Fragments;
GN   Name=gcg;
OS   Lithobates catesbeianus (American bullfrog) (Rana catesbeiana).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Lithobates.
OX   NCBI_TaxID=8400;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Pancreas;
RX   PubMed=3260236; DOI=10.1016/s0021-9258(19)81581-8;
RA   Pollock H.G., Hamilton J.W., Rouse J.B., Ebner K.E., Rawitch A.B.;
RT   "Isolation of peptide hormones from the pancreas of the bullfrog (Rana
RT   catesbeiana). Amino acid sequences of pancreatic polypeptide,
RT   oxyntomodulin, and two glucagon-like peptides.";
RL   J. Biol. Chem. 263:9746-9751(1988).
CC   -!- FUNCTION: [Glucagon]: Plays a key role in glucose metabolism and
CC       homeostasis. Regulates blood glucose by increasing gluconeogenesis and
CC       decreasing glycolysis. {ECO:0000250|UniProtKB:P01275}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- INDUCTION: Produced in the A cells of the islets of Langerhans in
CC       response to a drop in blood sugar concentration.
CC   -!- MISCELLANEOUS: X's in the sequence were included by homology with other
CC       species sequences.
CC   -!- SIMILARITY: Belongs to the glucagon family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   PIR; B28091; GCFGB.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR015550; Glucagon.
DR   InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR   PANTHER; PTHR11418; PTHR11418; 1.
DR   Pfam; PF00123; Hormone_2; 3.
DR   PRINTS; PR00275; GLUCAGON.
DR   SMART; SM00070; GLUCA; 3.
DR   PROSITE; PS00260; GLUCAGON; 3.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Hormone; Secreted.
FT   PEPTIDE         1..36
FT                   /note="Oxyntomodulin"
FT                   /evidence="ECO:0000269|PubMed:3260236"
FT                   /id="PRO_0000011383"
FT   PEPTIDE         1..29
FT                   /note="Glucagon"
FT                   /evidence="ECO:0000269|PubMed:3260236"
FT                   /id="PRO_0000011384"
FT   PEPTIDE         39..70
FT                   /note="Glucagon-like peptide 1"
FT                   /evidence="ECO:0000269|PubMed:3260236"
FT                   /id="PRO_0000011385"
FT   PEPTIDE         71..103
FT                   /note="Glucagon-like peptide 2"
FT                   /evidence="ECO:0000269|PubMed:3260236"
FT                   /id="PRO_0000011386"
FT   NON_CONS        70..71
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   103 AA;  11721 MW;  316287B7BAE1C8F7 CRC64;
     HSQGTFTSDY SKYLDSRRAQ DFVQWLMNSK RSGGISXXHA DGTFTSDMSS YLEEKAAKEF
     VDWLIKGRPK HADGSFTSDF NKALDIKAAQ EFLDWIINTP VKE