ID   GLUC_MELGA              Reviewed;          29 AA.
AC   P68260; P01277; Q91410;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Glucagon;
GN   Name=GCG;
OS   Meleagris gallopavo (Wild turkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Meleagridinae; Meleagris.
OX   NCBI_TaxID=9103;
RN   [1]
RP   PROTEIN SEQUENCE, AMINO-ACID COMPOSITION, AND CRYSTALLIZATION.
RX   PubMed=4645932; DOI=10.1055/s-0028-1094032;
RA   Markussen J., Frandsen E.K., Heding L.G., Sundby F.;
RT   "Turkey glucagon: crystallization, amino acid composition and immunology.";
RL   Horm. Metab. Res. 4:360-363(1972).
CC   -!- FUNCTION: Glucagon plays a key role in glucose metabolism and
CC       homeostasis. Regulates blood glucose by increasing gluconeogenesis and
CC       decreasing glycolysis (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the glucagon family. {ECO:0000305}.
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DR   AlphaFoldDB; P68260; -.
DR   SMR; P68260; -.
DR   HOGENOM; CLU_090687_0_0_1; -.
DR   InParanoid; P68260; -.
DR   Proteomes; UP000001645; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR015550; Glucagon.
DR   InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR   PANTHER; PTHR11418; PTHR11418; 1.
DR   Pfam; PF00123; Hormone_2; 1.
DR   PRINTS; PR00275; GLUCAGON.
DR   SMART; SM00070; GLUCA; 1.
DR   PROSITE; PS00260; GLUCAGON; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Hormone; Reference proteome; Secreted.
FT   PEPTIDE         1..29
FT                   /note="Glucagon"
FT                   /id="PRO_0000043923"
SQ   SEQUENCE   29 AA;  3456 MW;  04D474D35C752B27 CRC64;
     HSQGTFTSDY SKYLDSRRAQ DFVQWLMST