ID   GLUC_MYOSC              Reviewed;          96 AA.
AC   P09686;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   02-JUN-2021, entry version 77.
DE   RecName: Full=Pro-glucagon;
DE   Contains:
DE     RecName: Full=Glicentin-related polypeptide;
DE              Short=GRPP;
DE   Contains:
DE     RecName: Full=Glucagon;
DE   Contains:
DE     RecName: Full=Glucagon-like peptide;
DE   Flags: Precursor; Fragment;
GN   Name=gcg;
OS   Myoxocephalus scorpius (Shorthorn sculpin) (Cottus scorpius).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Cottioidei; Cottales; Cottidae; Myoxocephalus.
OX   NCBI_TaxID=8097;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=3549298; DOI=10.1111/j.1432-1033.1987.tb11001.x;
RA   Conlon J.M., Falkmer S., Thim L.;
RT   "Primary structures of three fragments of proglucagon from the pancreatic
RT   islets of the daddy Sculpin (Cottus scorpius).";
RL   Eur. J. Biochem. 164:117-122(1987).
CC   -!- FUNCTION: [Glucagon]: Plays a key role in glucose metabolism and
CC       homeostasis. Regulates blood glucose by increasing gluconeogenesis and
CC       decreasing glycolysis. {ECO:0000250|UniProtKB:P01275}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- INDUCTION: Produced in the A cells of the islets of Langerhans in
CC       response to a drop in blood sugar concentration.
CC   -!- MISCELLANEOUS: X's in the sequence were included by homology with
CC       American goosefish sequences.
CC   -!- SIMILARITY: Belongs to the glucagon family. {ECO:0000305}.
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DR   PIR; A27188; GCFIS.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR015550; Glucagon.
DR   InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR   PANTHER; PTHR11418; PTHR11418; 1.
DR   Pfam; PF00123; Hormone_2; 2.
DR   PRINTS; PR00275; GLUCAGON.
DR   SMART; SM00070; GLUCA; 2.
DR   PROSITE; PS00260; GLUCAGON; 2.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues; Direct protein sequencing; Hormone;
KW   Secreted.
FT   PEPTIDE         1..26
FT                   /note="Glicentin-related polypeptide"
FT                   /evidence="ECO:0000269|PubMed:3549298"
FT                   /id="PRO_0000011352"
FT   PEPTIDE         29..57
FT                   /note="Glucagon"
FT                   /evidence="ECO:0000269|PubMed:3549298"
FT                   /id="PRO_0000011353"
FT   PEPTIDE         66..96
FT                   /note="Glucagon-like peptide"
FT                   /evidence="ECO:0000269|PubMed:3549298"
FT                   /id="PRO_0000011354"
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..26
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT   NON_TER         96
SQ   SEQUENCE   96 AA;  10755 MW;  C9900574FDB85750 CRC64;
     LQDAEDSSRF DADDTLAGEA RELSTPKXHS EGTFSNDYSK YLETRRAQDF VQWLKNSXXX
     XXXXXHADGT FTSDVSSYLN DQAIKDFVAK LKSGKV