ID   GLUC_PIAME              Reviewed;          71 AA.
AC   P81880;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 1.
DT   10-FEB-2021, entry version 64.
DE   RecName: Full=Pro-glucagon;
DE   Contains:
DE     RecName: Full=Glucagon;
DE   Contains:
DE     RecName: Full=Glucagon-like peptide;
DE   Flags: Precursor; Fragment;
GN   Name=gcg;
OS   Piaractus mesopotamicus (Pacu).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Piaractus.
OX   NCBI_TaxID=42528;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Pancreas;
RX   PubMed=10327603; DOI=10.1016/s0305-0491(98)10164-5;
RA   de Lima J.A., Oliveira B., Conlon J.M.;
RT   "Purification and characterization of insulin and peptides derived from
RT   proglucagon and prosomatostatin from the fruit-eating fish, the pacu
RT   Piaractus mesopotamicus.";
RL   Comp. Biochem. Physiol. 122B:127-135(1999).
CC   -!- FUNCTION: [Glucagon]: Plays a key role in glucose metabolism and
CC       homeostasis. Regulates blood glucose by increasing gluconeogenesis and
CC       decreasing glycolysis. {ECO:0000250|UniProtKB:P01275}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- INDUCTION: Produced in the A cells of the islets of Langerhans in
CC       response to a drop in blood sugar concentration.
CC   -!- MISCELLANEOUS: X's in the sequence were included by homology with other
CC       fish sequences.
CC   -!- SIMILARITY: Belongs to the glucagon family. {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR015550; Glucagon.
DR   InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR   PANTHER; PTHR11418; PTHR11418; 1.
DR   Pfam; PF00123; Hormone_2; 2.
DR   PRINTS; PR00275; GLUCAGON.
DR   SMART; SM00070; GLUCA; 2.
DR   PROSITE; PS00260; GLUCAGON; 2.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Hormone; Secreted.
FT   PEPTIDE         1..29
FT                   /note="Glucagon"
FT                   /evidence="ECO:0000269|PubMed:10327603"
FT                   /id="PRO_0000011381"
FT   PEPTIDE         38..71
FT                   /note="Glucagon-like peptide"
FT                   /evidence="ECO:0000269|PubMed:10327603"
FT                   /id="PRO_0000011382"
FT   NON_TER         1
FT   NON_TER         71
SQ   SEQUENCE   71 AA;  8155 MW;  F66A3CA2DD9806C5 CRC64;
     HSEGTFSNDY SKYLETQRAQ DFVQWLMNSX XXXXXXXHAD GTYTSDVSAY LQDQAAKDFI
     TWLKSGQPKQ E