ID   GLUC_POLSE              Reviewed;          29 AA.
AC   P0C235;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2006, sequence version 1.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=Glucagon;
GN   Name=gcg;
OS   Polypterus senegalus (Senegal bichir).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Polypteriformes; Polypteridae; Polypterus.
OX   NCBI_TaxID=55291;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=9446726; DOI=10.1006/gcen.1997.7007;
RA   Conlon J.M., Fan H.-Y., Fritzsch B.;
RT   "Purification and structural characterization of insulin and glucagon from
RT   the bichir Polypterus senegalis (Actinopterygii: Polypteriformes).";
RL   Gen. Comp. Endocrinol. 109:86-93(1998).
CC   -!- FUNCTION: Glucagon plays a key role in glucose metabolism and
CC       homeostasis. Regulates blood glucose by increasing gluconeogenesis and
CC       decreasing glycolysis.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- INDUCTION: Produced in the A cells of the islets of Langerhans in
CC       response to a drop in blood sugar concentration.
CC   -!- SIMILARITY: Belongs to the glucagon family. {ECO:0000305}.
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DR   AlphaFoldDB; P0C235; -.
DR   SMR; P0C235; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR015550; Glucagon.
DR   InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR   PANTHER; PTHR11418; PTHR11418; 1.
DR   Pfam; PF00123; Hormone_2; 1.
DR   PRINTS; PR00275; GLUCAGON.
DR   SMART; SM00070; GLUCA; 1.
DR   PROSITE; PS00260; GLUCAGON; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Hormone; Secreted.
FT   PEPTIDE         1..29
FT                   /note="Glucagon"
FT                   /id="PRO_0000260295"
SQ   SEQUENCE   29 AA;  3525 MW;  2B0471D30C60F10D CRC64;
     HSQGTFTNDY TKYQDSRRAQ DFVQWLMSN