ID   GLUC_RABIT              Reviewed;          29 AA.
AC   P68274; P25449;
DT   25-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Glucagon;
GN   Name=GCG;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=5011077; DOI=10.1055/s-0028-1097080;
RA   Sundby F., Markussen J.;
RT   "Rabbit glucagon: isolation, crystallization and amino acid composition.";
RL   Horm. Metab. Res. 4:56-56(1972).
CC   -!- FUNCTION: Glucagon plays a key role in glucose metabolism and
CC       homeostasis. Regulates blood glucose by increasing gluconeogenesis and
CC       decreasing glycolysis (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- INDUCTION: Produced in the A cells of the islets of Langerhans in
CC       response to a drop in blood sugar concentration. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the glucagon family. {ECO:0000305}.
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DR   PIR; A91741; A91741.
DR   AlphaFoldDB; P68274; -.
DR   BMRB; P68274; -.
DR   SMR; P68274; -.
DR   STRING; 9986.ENSOCUP00000019727; -.
DR   eggNOG; ENOG502RYPR; Eukaryota.
DR   InParanoid; P68274; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007188; P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway; IEA:UniProt.
DR   InterPro; IPR015550; Glucagon.
DR   InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR   PANTHER; PTHR11418; PTHR11418; 1.
DR   Pfam; PF00123; Hormone_2; 1.
DR   PRINTS; PR00275; GLUCAGON.
DR   SMART; SM00070; GLUCA; 1.
DR   PROSITE; PS00260; GLUCAGON; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Hormone; Phosphoprotein; Reference proteome;
KW   Secreted.
FT   PEPTIDE         1..29
FT                   /note="Glucagon"
FT                   /id="PRO_0000043919"
FT   MOD_RES         2
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P55095"
SQ   SEQUENCE   29 AA;  3483 MW;  04C584D35C752B27 CRC64;
     HSQGTFTSDY SKYLDSRRAQ DFVQWLMNT