ID   GLUC_SCYCA              Reviewed;          62 AA.
AC   P09687; Q9PRW8; Q9PRW9; Q9PRX0;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   30-AUG-2002, sequence version 2.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Glucagon;
DE   Contains:
DE     RecName: Full=Glucagon-33;
DE   Contains:
DE     RecName: Full=Glucagon-29;
DE   Contains:
DE     RecName: Full=Glucagon-like peptide;
DE   Flags: Precursor; Fragments;
GN   Name=gcg;
OS   Scyliorhinus canicula (Small-spotted catshark) (Squalus canicula).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Elasmobranchii; Galeomorphii; Galeoidea; Carcharhiniformes; Scyliorhinidae;
OC   Scyliorhinus.
OX   NCBI_TaxID=7830;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Pancreas;
RX   PubMed=8015974; DOI=10.1016/0196-9781(94)90186-4;
RA   Conlon J.M., Hazon N., Thim L.;
RT   "Primary structures of peptides derived from proglucagon isolated from the
RT   pancreas of the elasmobranch fish, Scyliorhinus canicula.";
RL   Peptides 15:163-167(1994).
RN   [2]
RP   PROTEIN SEQUENCE OF 1-29.
RC   TISSUE=Pancreas;
RX   PubMed=3569517; DOI=10.1016/0014-5793(87)80011-x;
RA   Conlon J.M., O'Toole L., Thim L.;
RT   "Primary structure of glucagon from the gut of the common dogfish
RT   (Scyliorhinus canicula).";
RL   FEBS Lett. 214:50-56(1987).
CC   -!- FUNCTION: Promotes hydrolysis of glycogen and lipids, and raises the
CC       blood sugar level.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- INDUCTION: Produced in the A cells of the islets of Langerhans in
CC       response to a drop in blood sugar concentration.
CC   -!- SIMILARITY: Belongs to the glucagon family. {ECO:0000305}.
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DR   PIR; A26992; GCDF.
DR   AlphaFoldDB; P09687; -.
DR   SMR; P09687; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR015550; Glucagon.
DR   InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR   PANTHER; PTHR11418; PTHR11418; 1.
DR   Pfam; PF00123; Hormone_2; 1.
DR   PRINTS; PR00275; GLUCAGON.
DR   SMART; SM00070; GLUCA; 2.
DR   PROSITE; PS00260; GLUCAGON; 2.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Hormone; Secreted.
FT   PEPTIDE         1..33
FT                   /note="Glucagon-33"
FT                   /id="PRO_0000011387"
FT   PEPTIDE         1..29
FT                   /note="Glucagon-29"
FT                   /id="PRO_0000011388"
FT   PEPTIDE         34..62
FT                   /note="Glucagon-like peptide"
FT                   /id="PRO_0000011389"
FT   CONFLICT        28
FT                   /note="S -> N (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   NON_CONS        33..34
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   62 AA;  7270 MW;  C5FF487C12C69CD1 CRC64;
     HSEGTFTSDY SKYMDNRRAK DFVQWLMSTK RNGHAEGTYT SDVDSLSDYF KAKRFVDSLK
     SY