ID   GLUC_THUOB              Reviewed;          29 AA.
AC   P68957; P23062;
DT   01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 43.
DE   RecName: Full=Glucagon;
GN   Name=gcg;
OS   Thunnus obesus (Bigeye tuna).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Pelagiaria; Scombriformes; Scombridae; Thunnus.
OX   NCBI_TaxID=8241;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Pancreas;
RX   PubMed=1916209; DOI=10.1016/0016-6480(91)90025-2;
RA   Navarro I., Gutierrez J., Caixach J., Rivera J., Planas J.;
RT   "Isolation and primary structure of glucagon from the endocrine pancreas of
RT   Thunnus obesus.";
RL   Gen. Comp. Endocrinol. 83:227-232(1991).
CC   -!- FUNCTION: Promotes hydrolysis of glycogen and lipids, and raises the
CC       blood sugar level.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- INDUCTION: Produced in the A cells of the islets of Langerhans in
CC       response to a drop in blood sugar concentration.
CC   -!- SIMILARITY: Belongs to the glucagon family. {ECO:0000305}.
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DR   PIR; A61135; A61135.
DR   AlphaFoldDB; P68957; -.
DR   SMR; P68957; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR015550; Glucagon.
DR   InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR   PANTHER; PTHR11418; PTHR11418; 1.
DR   Pfam; PF00123; Hormone_2; 1.
DR   PRINTS; PR00275; GLUCAGON.
DR   SMART; SM00070; GLUCA; 1.
DR   PROSITE; PS00260; GLUCAGON; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Hormone; Secreted.
FT   PEPTIDE         1..29
FT                   /note="Glucagon"
FT                   /id="PRO_0000043928"
SQ   SEQUENCE   29 AA;  3508 MW;  77D5943208662E52 CRC64;
     HSEGTFSNDY SKYLETRRAQ DFVQWLKNS