ID   GLUP_HELPY              Reviewed;         407 AA.
AC   O25788;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 113.
DE   RecName: Full=Putative glucose/galactose transporter;
GN   Name=gluP; OrderedLocusNames=HP_1174;
OS   Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700392 / 26695;
RX   PubMed=9252185; DOI=10.1038/41483;
RA   Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA   Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA   Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA   Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA   McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA   Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA   Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA   Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT   "The complete genome sequence of the gastric pathogen Helicobacter
RT   pylori.";
RL   Nature 388:539-547(1997).
CC   -!- FUNCTION: Intake of glucose and galactose. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. FHS
CC       transporter (TC 2.A.1.7) family. {ECO:0000305}.
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DR   EMBL; AE000511; AAD08219.1; -; Genomic_DNA.
DR   PIR; F64666; F64666.
DR   RefSeq; NP_207965.1; NC_000915.1.
DR   RefSeq; WP_001174195.1; NC_018939.1.
DR   AlphaFoldDB; O25788; -.
DR   SMR; O25788; -.
DR   IntAct; O25788; 1.
DR   STRING; 85962.C694_06065; -.
DR   TCDB; 2.A.1.7.7; the major facilitator superfamily (mfs).
DR   PaxDb; O25788; -.
DR   EnsemblBacteria; AAD08219; AAD08219; HP_1174.
DR   KEGG; hpy:HP_1174; -.
DR   PATRIC; fig|85962.47.peg.1261; -.
DR   eggNOG; COG0738; Bacteria.
DR   OMA; TGMSMLY; -.
DR   PhylomeDB; O25788; -.
DR   Proteomes; UP000000429; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005354; F:galactose transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0005355; F:glucose transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR005964; Glc/Gal_transptr_bac.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR01272; gluP; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..407
FT                   /note="Putative glucose/galactose transporter"
FT                   /id="PRO_0000094506"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        47..67
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        70..90
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        96..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        180..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        225..245
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        263..283
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        300..320
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        321..341
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        349..369
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        378..398
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   407 AA;  43950 MW;  447B5CCF6117D712 CRC64;
     MQKTSNTLAL GSLTALFFLM GFITVLNDIL IPHLKPIFDL TYFEASLIQF CFFGAYFIMG
     GVFGNVISKI GYPFGVVLGF VITATGCALF YPAAHFGSYG FFLGALFILA SGIVCLQTAG
     NPFVTLLSKG KEARNLVLVQ AFNSLGTTLG PIFGSLLIFS TTKMGDNASL IDKLADAKSV
     QMPYLGLAVF SLLLALIMYL LKLPDVEKEM PKETTQKSLF SHKHFVFGAL GIFFYVGGEV
     AIGSFLVLSF EKLLNLDSQS SAHYLVYYWG GAMVGRFLGS VLMNKIAPNK YLAFNALSSI
     VLIALAIIIG GKIALFALTF VGFFNSIMFP TIFSLATLNL GHLTSKASGV ISMAIVGGAL
     IPPIQGAVTD MLTATESNLL YAYGVPLLCY FYILFFALKG YKQEENS