GLV10_ARATH
ID GLV10_ARATH Reviewed; 88 AA.
AC B3H5J1;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 1.
DT 03-AUG-2022, entry version 62.
DE RecName: Full=Protein GOLVEN 10 {ECO:0000303|PubMed:23370719};
DE AltName: Full=CLAVATA3/ESR (CLE)-related protein CLEL7 {ECO:0000303|PubMed:22307643};
DE Short=CLE-Like protein 7 {ECO:0000303|PubMed:22307643};
DE AltName: Full=Root meristem growth factor 5 {ECO:0000303|PubMed:20798316};
DE Short=AtRGF5 {ECO:0000303|PubMed:20798316};
DE Contains:
DE RecName: Full=GLV10p {ECO:0000303|PubMed:23370719};
DE Flags: Precursor;
GN Name=GLV10 {ECO:0000303|PubMed:23370719};
GN Synonyms=CLEL7 {ECO:0000303|PubMed:22307643},
GN RGF5 {ECO:0000303|PubMed:20798316};
GN OrderedLocusNames=At5g51451 {ECO:0000312|Araport:AT5G51451};
GN ORFNames=MFG13 {ECO:0000312|EMBL:AB025621};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RA Kaneko T., Katoh T., Asamizu E., Sato S., Nakamura Y., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. XI.";
RL Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Jakoby M., Stracke R., Soerensen T.R., Weisshaar B.;
RT "Arabidopsis thaliana cDNA library enriched in transcription factors.";
RL Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP FUNCTION, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=20798316; DOI=10.1126/science.1191132;
RA Matsuzaki Y., Ogawa-Ohnishi M., Mori A., Matsubayashi Y.;
RT "Secreted peptide signals required for maintenance of root stem cell niche
RT in Arabidopsis.";
RL Science 329:1065-1067(2010).
RN [5]
RP FUNCTION, SUBCELLULAR LOCATION, NOMENCLATURE, AND GENE FAMILY.
RC STRAIN=cv. Columbia;
RX PubMed=22307643; DOI=10.1073/pnas.1119864109;
RA Meng L., Buchanan B.B., Feldman L.J., Luan S.;
RT "CLE-like (CLEL) peptides control the pattern of root growth and lateral
RT root development in Arabidopsis.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:1760-1765(2012).
RN [6]
RP FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC STRAIN=cv. Columbia;
RX PubMed=23370719; DOI=10.1104/pp.112.206029;
RA Fernandez A., Drozdzecki A., Hoogewijs K., Nguyen A., Beeckman T.,
RA Madder A., Hilson P.;
RT "Transcriptional and functional classification of the GOLVEN/ROOT GROWTH
RT FACTOR/CLE-like signaling peptides reveals their role in lateral root and
RT hair formation.";
RL Plant Physiol. 161:954-970(2013).
RN [7]
RP INTERACTION WITH RGI1; RGI2 AND RGI3.
RC STRAIN=cv. Columbia;
RX PubMed=27001831; DOI=10.1073/pnas.1522639113;
RA Shinohara H., Mori A., Yasue N., Sumida K., Matsubayashi Y.;
RT "Identification of three LRR-RKs involved in perception of root meristem
RT growth factor in Arabidopsis.";
RL Proc. Natl. Acad. Sci. U.S.A. 113:3897-3902(2016).
RN [8]
RP X-RAY CRYSTALLOGRAPHY (2.86 ANGSTROMS) OF 76-88.
RA Song W., Han Z., Chai J.;
RT "Plant Receptor.";
RL Submitted (FEB-2016) to the PDB data bank.
CC -!- FUNCTION: [GLV10p]: Signaling peptide (root growth factor) that
CC maintains the postembryonic root stem cell niche (PubMed:20798316).
CC Regulates the pattern of root growth and lateral root development by
CC modulating the length and the number of cortical cells in the root
CC apical meristem (RAM), and the anticlinal asymmetric cell divisions in
CC lateral root initiation cells (PubMed:22307643, PubMed:23370719).
CC {ECO:0000269|PubMed:20798316, ECO:0000269|PubMed:22307643,
CC ECO:0000269|PubMed:23370719}.
CC -!- SUBUNIT: [GLV10p]: Binds to LRR receptor-like serine/threonine-protein
CC kinases RGI1, RGI2 and RGI3 to trigger their dimerization with SERK
CC proteins and subsequent signaling. {ECO:0000269|PubMed:27001831}.
CC -!- SUBCELLULAR LOCATION: [GLV10p]: Secreted {ECO:0000305|PubMed:22307643}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC {ECO:0000269|PubMed:22307643}. Note=The precursor is detected in the
CC endoplasmic reticulum probably during its processing.
CC {ECO:0000269|PubMed:22307643}.
CC -!- TISSUE SPECIFICITY: Expressed in roots, shoots, leaves and flowers.
CC {ECO:0000269|PubMed:23370719}.
CC -!- DEVELOPMENTAL STAGE: In roots, expressed only in the quiescent center
CC (QC) and the columella stem cells (CC) initials (PubMed:23370719).
CC Slightly observed in additional underlying CCs and in the vascular
CC initials above the QC (PubMed:23370719). Induced early during lateral
CC root formation (PubMed:23370719). {ECO:0000269|PubMed:23370719}.
CC -!- MISCELLANEOUS: 'Golven' means irregular waves in Dutch.
CC {ECO:0000305|PubMed:23370719}.
CC -!- SIMILARITY: Belongs to the RGF family. {ECO:0000305}.
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DR EMBL; AB025621; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002688; AED96084.1; -; Genomic_DNA.
DR EMBL; CB254977; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; NP_001119414.1; NM_001125942.2.
DR PDB; 5HZ3; X-ray; 2.86 A; A=76-88.
DR PDBsum; 5HZ3; -.
DR AlphaFoldDB; B3H5J1; -.
DR SMR; B3H5J1; -.
DR STRING; 3702.AT5G51451.1; -.
DR PaxDb; B3H5J1; -.
DR EnsemblPlants; AT5G51451.1; AT5G51451.1; AT5G51451.
DR GeneID; 6241076; -.
DR Gramene; AT5G51451.1; AT5G51451.1; AT5G51451.
DR KEGG; ath:AT5G51451; -.
DR Araport; AT5G51451; -.
DR TAIR; locus:4515103716; AT5G51451.
DR eggNOG; ENOG502R1RU; Eukaryota.
DR HOGENOM; CLU_2486407_0_0_1; -.
DR OMA; AVKHHHR; -.
DR OrthoDB; 1612508at2759; -.
DR PRO; PR:B3H5J1; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; B3H5J1; baseline and differential.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR GO; GO:0008083; F:growth factor activity; IDA:UniProtKB.
DR GO; GO:0030154; P:cell differentiation; IDA:UniProtKB.
DR GO; GO:0048527; P:lateral root development; IMP:TAIR.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IDA:UniProtKB.
DR GO; GO:0009786; P:regulation of asymmetric cell division; IDA:UniProtKB.
DR GO; GO:2000023; P:regulation of lateral root development; IDA:UniProtKB.
DR GO; GO:0010082; P:regulation of root meristem growth; IDA:UniProtKB.
DR GO; GO:2000067; P:regulation of root morphogenesis; IDA:UniProtKB.
DR GO; GO:0022622; P:root system development; IMP:TAIR.
PE 1: Evidence at protein level;
KW 3D-structure; Differentiation; Endoplasmic reticulum; Growth factor;
KW Hydroxylation; Reference proteome; Secreted; Signal; Sulfation.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT PROPEP 23..75
FT /evidence="ECO:0000250|UniProtKB:Q3E880"
FT /id="PRO_0000401447"
FT PEPTIDE 76..88
FT /note="GLV10p"
FT /id="PRO_0000401448"
FT REGION 44..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 77
FT /note="Sulfotyrosine"
FT /evidence="ECO:0000250|UniProtKB:Q3E880"
FT MOD_RES 85
FT /note="Hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:O49519"
SQ SEQUENCE 88 AA; 10052 MW; B1BDCB5EA079E7F4 CRC64;
MSSIHVASMI LLLFLFLHHS DSRHLDNVHI TASRFSLVKD QNVVSSSTSK EPVKVSRFVP
GPLKHHHRRP PLLFADYPKP STRPPRHN
