GLV1_ARATH
ID GLV1_ARATH Reviewed; 86 AA.
AC Q93VK8;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 25-MAY-2022, entry version 83.
DE RecName: Full=Protein GOLVEN 1 {ECO:0000303|PubMed:23370719};
DE AltName: Full=CLAVATA3/ESR (CLE)-related protein CLEL6 {ECO:0000303|PubMed:22307643};
DE Short=CLE-Like protein 6 {ECO:0000303|PubMed:22307643};
DE AltName: Full=Root meristem growth factor 6 {ECO:0000303|PubMed:20798316};
DE Short=AtRGF6 {ECO:0000303|PubMed:20798316};
DE Contains:
DE RecName: Full=GLV1p {ECO:0000303|PubMed:22421050};
DE Flags: Precursor;
GN Name=GLV1 {ECO:0000303|PubMed:23370719};
GN Synonyms=CLEL6 {ECO:0000303|PubMed:22307643},
GN RGF6 {ECO:0000303|PubMed:20798316};
GN OrderedLocusNames=At4g16515 {ECO:0000312|Araport:AT4G16515};
GN ORFNames=FCAALL {ECO:0000312|EMBL:AL161544};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP FUNCTION, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=20798316; DOI=10.1126/science.1191132;
RA Matsuzaki Y., Ogawa-Ohnishi M., Mori A., Matsubayashi Y.;
RT "Secreted peptide signals required for maintenance of root stem cell niche
RT in Arabidopsis.";
RL Science 329:1065-1067(2010).
RN [6]
RP FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE,
RP IDENTIFICATION BY MASS SPECTROMETRY, HYDROXYLATION AT PRO-80, SULFATION AT
RP TYR-72, AND INDUCTION BY AUXIN.
RX PubMed=22421050; DOI=10.1016/j.devcel.2012.02.002;
RA Whitford R., Fernandez A., Tejos R., Perez A.C., Kleine-Vehn J.,
RA Vanneste S., Drozdzecki A., Leitner J., Abas L., Aerts M., Hoogewijs K.,
RA Baster P., De Groodt R., Lin Y.-C., Storme V., Van de Peer Y., Beeckman T.,
RA Madder A., Devreese B., Luschnig C., Friml J., Hilson P.;
RT "GOLVEN secretory peptides regulate auxin carrier turnover during plant
RT gravitropic responses.";
RL Dev. Cell 22:678-685(2012).
RN [7]
RP FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, NOMENCLATURE, AND GENE
RP FAMILY.
RC STRAIN=cv. Columbia;
RX PubMed=22307643; DOI=10.1073/pnas.1119864109;
RA Meng L., Buchanan B.B., Feldman L.J., Luan S.;
RT "CLE-like (CLEL) peptides control the pattern of root growth and lateral
RT root development in Arabidopsis.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:1760-1765(2012).
RN [8]
RP FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC STRAIN=cv. Columbia;
RX PubMed=23370719; DOI=10.1104/pp.112.206029;
RA Fernandez A., Drozdzecki A., Hoogewijs K., Nguyen A., Beeckman T.,
RA Madder A., Hilson P.;
RT "Transcriptional and functional classification of the GOLVEN/ROOT GROWTH
RT FACTOR/CLE-like signaling peptides reveals their role in lateral root and
RT hair formation.";
RL Plant Physiol. 161:954-970(2013).
CC -!- FUNCTION: [GLV1p]: Signaling peptide (root growth factor) that
CC regulates the pattern of root growth and lateral root development by
CC modulating the length and the number of cortical cells in the root
CC apical meristem (RAM), and the anticlinal asymmetric cell divisions in
CC lateral root initiation cells (PubMed:22307643, PubMed:23370719). Also
CC involved in the regulation of hypocotyl bending and root gravitropism
CC in a PIN2-traffic dependent manner, thus influencing the formation of
CC auxin gradients (PubMed:22421050). Maintains the postembryonic root
CC stem cell niche (PubMed:20798316). {ECO:0000269|PubMed:20798316,
CC ECO:0000269|PubMed:22307643, ECO:0000269|PubMed:22421050,
CC ECO:0000269|PubMed:23370719}.
CC -!- SUBUNIT: [GLV1p]: Binds to LRR receptor-like serine/threonine-protein
CC kinases to trigger their dimerization with SERK proteins and subsequent
CC signaling. {ECO:0000250|UniProtKB:Q9LI64}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC {ECO:0000269|PubMed:22307643}. Note=The precursor is detected in the
CC endoplasmic reticulum probably during its processing.
CC {ECO:0000269|PubMed:22307643}.
CC -!- SUBCELLULAR LOCATION: [GLV1p]: Secreted {ECO:0000305|PubMed:22307643}.
CC -!- TISSUE SPECIFICITY: Expressed in stems, hypocotyls, cotyledons, leaves,
CC flowers, shoot apex, siliques, stamens and petals.
CC {ECO:0000269|PubMed:22307643, ECO:0000269|PubMed:22421050,
CC ECO:0000269|PubMed:23370719}.
CC -!- DEVELOPMENTAL STAGE: Absent from the primary root (PubMed:23370719).
CC Expressed irregularly throughout the cotyledon and accumulates at the
CC base of the organ (PubMed:23370719). In leaves, present at a high level
CC in the basal part, close to the main veins, irregularly in the lamina
CC joining these veins, and in separate segments of the leaf margin
CC (PubMed:23370719). Observed in the stem, the rachis of the
CC inflorescence, and the lower portion of the flower pedicel, especially
CC at its upper side (PubMed:23370719). In flowers, detected throughout
CC its development at the base of the sepals, in the petals, the filament
CC of the stamens and the gynoecium, and later in siliques
CC (PubMed:23370719). During seedling gravitropic response, restricted to
CC the epidermis and cortex and enhanced at the lower side of the
CC reoriented hypocotyl (PubMed:22421050). {ECO:0000269|PubMed:22421050,
CC ECO:0000269|PubMed:23370719}.
CC -!- INDUCTION: Rapidly induced by auxin. {ECO:0000269|PubMed:22421050}.
CC -!- DISRUPTION PHENOTYPE: Reduced hypocotyl bending and dose-dependent
CC altered root gravitropism associated with an altered PIN2 traffic that
CC impairs the formation of auxin gradients, thus leading to an irregular
CC waves root shape. {ECO:0000269|PubMed:22421050}.
CC -!- MISCELLANEOUS: 'Golven' means irregular waves in Dutch.
CC {ECO:0000305|PubMed:22421050}.
CC -!- SIMILARITY: Belongs to the RGF family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL161544; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002687; AEE83763.1; -; Genomic_DNA.
DR EMBL; AF380632; AAK55713.1; -; mRNA.
DR EMBL; AY054128; AAL06789.1; -; mRNA.
DR EMBL; AY088419; AAM65956.1; -; mRNA.
DR RefSeq; NP_567503.1; NM_117750.3.
DR AlphaFoldDB; Q93VK8; -.
DR STRING; 3702.AT4G16515.1; -.
DR PaxDb; Q93VK8; -.
DR EnsemblPlants; AT4G16515.1; AT4G16515.1; AT4G16515.
DR GeneID; 827350; -.
DR Gramene; AT4G16515.1; AT4G16515.1; AT4G16515.
DR KEGG; ath:AT4G16515; -.
DR Araport; AT4G16515; -.
DR TAIR; locus:505006482; AT4G16515.
DR HOGENOM; CLU_2593098_0_0_1; -.
DR OMA; SMVFCFI; -.
DR PRO; PR:Q93VK8; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q93VK8; differential.
DR Genevisible; Q93VK8; AT.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR GO; GO:0008083; F:growth factor activity; IDA:UniProtKB.
DR GO; GO:0005179; F:hormone activity; IDA:UniProtKB.
DR GO; GO:0030154; P:cell differentiation; IDA:UniProtKB.
DR GO; GO:0048527; P:lateral root development; IMP:TAIR.
DR GO; GO:0009958; P:positive gravitropism; IMP:TAIR.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IDA:UniProtKB.
DR GO; GO:0009786; P:regulation of asymmetric cell division; IDA:UniProtKB.
DR GO; GO:2000012; P:regulation of auxin polar transport; IMP:TAIR.
DR GO; GO:2000023; P:regulation of lateral root development; IDA:UniProtKB.
DR GO; GO:0032880; P:regulation of protein localization; IDA:TAIR.
DR GO; GO:2000280; P:regulation of root development; IMP:UniProtKB.
DR GO; GO:0010082; P:regulation of root meristem growth; IDA:UniProtKB.
DR GO; GO:2000067; P:regulation of root morphogenesis; IDA:UniProtKB.
DR GO; GO:0009733; P:response to auxin; IEP:UniProtKB.
DR GO; GO:0022622; P:root system development; IMP:TAIR.
PE 1: Evidence at protein level;
KW Differentiation; Endoplasmic reticulum; Growth factor; Hydroxylation;
KW Reference proteome; Secreted; Signal; Sulfation.
FT SIGNAL 1..29
FT /evidence="ECO:0000255"
FT PROPEP 30..70
FT /evidence="ECO:0000250|UniProtKB:Q3E880"
FT /id="PRO_0000401449"
FT PEPTIDE 71..83
FT /note="GLV1p"
FT /id="PRO_0000401450"
FT PROPEP 84..86
FT /evidence="ECO:0000250|UniProtKB:Q3E880"
FT /id="PRO_0000401451"
FT MOD_RES 72
FT /note="Sulfotyrosine"
FT /evidence="ECO:0000269|PubMed:22421050"
FT MOD_RES 80
FT /note="Hydroxyproline"
FT /evidence="ECO:0000269|PubMed:22421050"
SQ SEQUENCE 86 AA; 9541 MW; A37697E69DE9B7F3 CRC64;
MSCSLRSGLV IVFCFILLLL SSNVGCASAA RRLRSHKHHH HKVASLDVFN GGERRRALGG
VETGEEVVVM DYPQPHRKPP IHNEKS
