GLV4_ARATH
ID GLV4_ARATH Reviewed; 102 AA.
AC Q6NNL3; Q9SRU0;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 78.
DE RecName: Full=Protein GOLVEN 4 {ECO:0000303|PubMed:23370719};
DE AltName: Full=CLAVATA3/ESR (CLE)-related protein CLEL4 {ECO:0000303|PubMed:22307643};
DE Short=CLE-Like protein 4 {ECO:0000303|PubMed:22307643};
DE AltName: Full=Root meristem growth factor 7 {ECO:0000303|PubMed:20798316};
DE Short=AtRGF7 {ECO:0000303|PubMed:20798316};
DE Contains:
DE RecName: Full=GLV4p {ECO:0000303|PubMed:23370719};
DE Flags: Precursor;
GN Name=GLV4 {ECO:0000303|PubMed:23370719};
GN Synonyms=CLEL4 {ECO:0000303|PubMed:22307643},
GN RGF7 {ECO:0000303|PubMed:20798316};
GN OrderedLocusNames=At3g02240 {ECO:0000312|Araport:AT3G02240};
GN ORFNames=F14P3.11 {ECO:0000312|EMBL:AAF02114.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Cheuk R., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT "Arabidopsis cDNA clones.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP FUNCTION, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=20798316; DOI=10.1126/science.1191132;
RA Matsuzaki Y., Ogawa-Ohnishi M., Mori A., Matsubayashi Y.;
RT "Secreted peptide signals required for maintenance of root stem cell niche
RT in Arabidopsis.";
RL Science 329:1065-1067(2010).
RN [5]
RP TISSUE SPECIFICITY, NOMENCLATURE, AND GENE FAMILY.
RC STRAIN=cv. Columbia;
RX PubMed=22307643; DOI=10.1073/pnas.1119864109;
RA Meng L., Buchanan B.B., Feldman L.J., Luan S.;
RT "CLE-like (CLEL) peptides control the pattern of root growth and lateral
RT root development in Arabidopsis.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:1760-1765(2012).
RN [6]
RP FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RC STRAIN=cv. Columbia;
RX PubMed=23370719; DOI=10.1104/pp.112.206029;
RA Fernandez A., Drozdzecki A., Hoogewijs K., Nguyen A., Beeckman T.,
RA Madder A., Hilson P.;
RT "Transcriptional and functional classification of the GOLVEN/ROOT GROWTH
RT FACTOR/CLE-like signaling peptides reveals their role in lateral root and
RT hair formation.";
RL Plant Physiol. 161:954-970(2013).
CC -!- FUNCTION: [GLV4p]: Signaling peptide (root growth factor) that promotes
CC root hairs formation and growth (PubMed:23370719). Maintains the
CC postembryonic root stem cell niche (PubMed:20798316). Regulates the
CC pattern of root growth and lateral root development by modulating the
CC length and the number of cortical cells in the root apical meristem
CC (RAM), and the anticlinal asymmetric cell divisions in lateral root
CC initiation cells (By similarity). {ECO:0000250|UniProtKB:Q93VK8,
CC ECO:0000269|PubMed:20798316, ECO:0000269|PubMed:23370719}.
CC -!- SUBUNIT: [GLV4p]: Binds to LRR receptor-like serine/threonine-protein
CC kinases to trigger their dimerization with SERK proteins and subsequent
CC signaling. {ECO:0000250|UniProtKB:Q9LI64}.
CC -!- SUBCELLULAR LOCATION: [GLV4p]: Secreted {ECO:0000250|UniProtKB:Q3E880}.
CC -!- TISSUE SPECIFICITY: Expressed in roots and sepals.
CC {ECO:0000269|PubMed:22307643, ECO:0000269|PubMed:23370719}.
CC -!- DEVELOPMENTAL STAGE: In roots, present in the root portion above the
CC meristem, mainly in the root elongation zone and the proximal region of
CC the differentiation zone; restricted to the epidermis
CC (PubMed:23370719). Induced during lateral root formation in mature
CC lateral roots (PubMed:23370719). {ECO:0000269|PubMed:23370719}.
CC -!- DISRUPTION PHENOTYPE: Shorter root hairs.
CC {ECO:0000269|PubMed:23370719}.
CC -!- MISCELLANEOUS: 'Golven' means irregular waves in Dutch.
CC {ECO:0000305|PubMed:23370719}.
CC -!- SIMILARITY: Belongs to the RGF family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF02114.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC009755; AAF02114.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE73782.1; -; Genomic_DNA.
DR EMBL; BT010792; AAR24159.1; -; mRNA.
DR EMBL; BT011273; AAR92309.1; -; mRNA.
DR RefSeq; NP_186873.2; NM_111091.5.
DR AlphaFoldDB; Q6NNL3; -.
DR SMR; Q6NNL3; -.
DR STRING; 3702.AT3G02240.1; -.
DR PaxDb; Q6NNL3; -.
DR PRIDE; Q6NNL3; -.
DR ProteomicsDB; 236997; -.
DR EnsemblPlants; AT3G02240.1; AT3G02240.1; AT3G02240.
DR GeneID; 820386; -.
DR Gramene; AT3G02240.1; AT3G02240.1; AT3G02240.
DR KEGG; ath:AT3G02240; -.
DR Araport; AT3G02240; -.
DR TAIR; locus:2076562; AT3G02240.
DR HOGENOM; CLU_2187525_0_0_1; -.
DR PhylomeDB; Q6NNL3; -.
DR PRO; PR:Q6NNL3; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q6NNL3; baseline and differential.
DR Genevisible; Q6NNL3; AT.
DR GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR GO; GO:0008083; F:growth factor activity; IDA:UniProtKB.
DR GO; GO:0030154; P:cell differentiation; IDA:UniProtKB.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IDA:UniProtKB.
DR GO; GO:0009786; P:regulation of asymmetric cell division; ISS:UniProtKB.
DR GO; GO:2000023; P:regulation of lateral root development; ISS:UniProtKB.
DR GO; GO:0010082; P:regulation of root meristem growth; ISS:UniProtKB.
DR GO; GO:2000067; P:regulation of root morphogenesis; ISS:UniProtKB.
PE 2: Evidence at transcript level;
KW Differentiation; Growth factor; Hydroxylation; Reference proteome;
KW Secreted; Signal; Sulfation.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT PROPEP 28..89
FT /evidence="ECO:0000250|UniProtKB:Q3E880"
FT /id="PRO_0000401452"
FT PEPTIDE 90..102
FT /note="GLV4p"
FT /id="PRO_0000401453"
FT REGION 56..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 91
FT /note="Sulfotyrosine"
FT /evidence="ECO:0000250|UniProtKB:Q3E880"
FT MOD_RES 99
FT /note="Hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:O49519"
SQ SEQUENCE 102 AA; 11972 MW; E7FC3C6374510A48 CRC64;
MEMKKWSYAN LITLALLFLF FIILLLAFQG GSRDDDHQHV HVAIRTKDIS MGRKLKSLKP
INPTKKNGFE YPDQGSHDVQ EREVYVELRD YGQRKYKPPV HN
