GLV6_ARATH
ID GLV6_ARATH Reviewed; 123 AA.
AC Q9SI57;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Protein GOLVEN 6 {ECO:0000303|PubMed:23370719};
DE AltName: Full=CLAVATA3/ESR (CLE)-related protein CLEL2 {ECO:0000303|PubMed:22307643};
DE Short=CLE-Like protein 2 {ECO:0000303|PubMed:22307643};
DE AltName: Full=Root meristem growth factor 8 {ECO:0000303|PubMed:20798316};
DE Short=AtRGF8 {ECO:0000303|PubMed:20798316};
DE Contains:
DE RecName: Full=GLV6p {ECO:0000303|PubMed:23370719};
DE Flags: Precursor;
GN Name=GLV6 {ECO:0000303|PubMed:23370719};
GN Synonyms=CLEL2 {ECO:0000303|PubMed:22307643},
GN RGF8 {ECO:0000303|PubMed:20798316};
GN OrderedLocusNames=At2g03830 {ECO:0000312|Araport:AT2G03830};
GN ORFNames=T18C20.3 {ECO:0000312|EMBL:AAD24817.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Underwood B.A., Xiao Y.-L., Moskal W.A. Jr., Monaghan E.L., Wang W.,
RA Redman J.C., Wu H.C., Utterback T., Town C.D.;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=16244158; DOI=10.1104/pp.105.063479;
RA Xiao Y.-L., Smith S.R., Ishmael N., Redman J.C., Kumar N., Monaghan E.L.,
RA Ayele M., Haas B.J., Wu H.C., Town C.D.;
RT "Analysis of the cDNAs of hypothetical genes on Arabidopsis chromosome 2
RT reveals numerous transcript variants.";
RL Plant Physiol. 139:1323-1337(2005).
RN [5]
RP FUNCTION, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=20798316; DOI=10.1126/science.1191132;
RA Matsuzaki Y., Ogawa-Ohnishi M., Mori A., Matsubayashi Y.;
RT "Secreted peptide signals required for maintenance of root stem cell niche
RT in Arabidopsis.";
RL Science 329:1065-1067(2010).
RN [6]
RP TISSUE SPECIFICITY, NOMENCLATURE, AND GENE FAMILY.
RC STRAIN=cv. Columbia;
RX PubMed=22307643; DOI=10.1073/pnas.1119864109;
RA Meng L., Buchanan B.B., Feldman L.J., Luan S.;
RT "CLE-like (CLEL) peptides control the pattern of root growth and lateral
RT root development in Arabidopsis.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:1760-1765(2012).
RN [7]
RP FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RC STRAIN=cv. Columbia;
RX PubMed=23370719; DOI=10.1104/pp.112.206029;
RA Fernandez A., Drozdzecki A., Hoogewijs K., Nguyen A., Beeckman T.,
RA Madder A., Hilson P.;
RT "Transcriptional and functional classification of the GOLVEN/ROOT GROWTH
RT FACTOR/CLE-like signaling peptides reveals their role in lateral root and
RT hair formation.";
RL Plant Physiol. 161:954-970(2013).
CC -!- FUNCTION: [GLV6p]: Signaling peptide (root growth factor) required
CC during root gravitropism in a PIN2-traffic dependent manner
CC (PubMed:23370719). May be involved in maintaining the postembryonic
CC root stem cell niche (PubMed:20798316). Root growth factor that
CC regulates the pattern of root growth and lateral root development by
CC modulating the length and the number of cortical cells in the root
CC apical meristem (RAM), and the anticlinal asymmetric cell divisions in
CC lateral root initiation cells (By similarity).
CC {ECO:0000250|UniProtKB:Q93VK8, ECO:0000269|PubMed:20798316,
CC ECO:0000269|PubMed:23370719}.
CC -!- SUBUNIT: [GLV6p]: Binds to LRR receptor-like serine/threonine-protein
CC kinases to trigger their dimerization with SERK proteins and subsequent
CC signaling. {ECO:0000250|UniProtKB:Q9LI64}.
CC -!- SUBCELLULAR LOCATION: [GLV6p]: Secreted {ECO:0000250|UniProtKB:Q3E880}.
CC -!- TISSUE SPECIFICITY: Expressed in roots, shoots, flowers and stamens.
CC {ECO:0000269|PubMed:22307643, ECO:0000269|PubMed:23370719}.
CC -!- DEVELOPMENTAL STAGE: In roots, present in both the quiescent center
CC (QC) and the root apical meristem (RAM); within the meristem, mainly
CC present in the cortex but also in the epidermal and procambial cells
CC closest to the QC, with very strong levels in the initials surrounding
CC the QC (PubMed:23370719). Also present in the QC, and the first and
CC second columella cells (CC) layers (PubMed:23370719). Induced early
CC during lateral root formation (PubMed:23370719). Detected in the
CC vasculature of cotyledons and leaves (PubMed:23370719). In the shoot
CC apical meristem (SAM), present at the border between the meristem and
CC the leaf primordia (PubMed:23370719). In flowers, accumulates in the
CC vasculature of sepals, stamens, and petals as well as at the tip of the
CC gynoecium and later in the siliques (PubMed:23370719).
CC {ECO:0000269|PubMed:23370719}.
CC -!- DISRUPTION PHENOTYPE: Altered PIN2 traffic.
CC {ECO:0000269|PubMed:23370719}.
CC -!- MISCELLANEOUS: 'Golven' means irregular waves in Dutch.
CC {ECO:0000305|PubMed:23370719}.
CC -!- SIMILARITY: Belongs to the RGF family. {ECO:0000305}.
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DR EMBL; AC007196; AAD24817.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC05757.1; -; Genomic_DNA.
DR EMBL; AY219139; AAO37226.1; -; mRNA.
DR EMBL; AY649256; AAT69173.1; -; mRNA.
DR PIR; G84452; G84452.
DR RefSeq; NP_178477.1; NM_126429.6.
DR AlphaFoldDB; Q9SI57; -.
DR STRING; 3702.AT2G03830.1; -.
DR PaxDb; Q9SI57; -.
DR PRIDE; Q9SI57; -.
DR EnsemblPlants; AT2G03830.1; AT2G03830.1; AT2G03830.
DR GeneID; 814909; -.
DR Gramene; AT2G03830.1; AT2G03830.1; AT2G03830.
DR KEGG; ath:AT2G03830; -.
DR Araport; AT2G03830; -.
DR TAIR; locus:2056805; AT2G03830.
DR eggNOG; ENOG502R6KF; Eukaryota.
DR HOGENOM; CLU_2161921_0_0_1; -.
DR InParanoid; Q9SI57; -.
DR OMA; SMDYRTF; -.
DR OrthoDB; 1459339at2759; -.
DR PRO; PR:Q9SI57; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9SI57; baseline and differential.
DR Genevisible; Q9SI57; AT.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0009786; P:regulation of asymmetric cell division; ISS:UniProtKB.
DR GO; GO:2000023; P:regulation of lateral root development; ISS:UniProtKB.
DR GO; GO:0010082; P:regulation of root meristem growth; ISS:UniProtKB.
DR GO; GO:2000067; P:regulation of root morphogenesis; ISS:UniProtKB.
PE 2: Evidence at transcript level;
KW Differentiation; Growth factor; Hydroxylation; Reference proteome;
KW Secreted; Signal; Sulfation.
FT SIGNAL 1..29
FT /evidence="ECO:0000255"
FT PROPEP 30..103
FT /evidence="ECO:0000250|UniProtKB:Q3E880"
FT /id="PRO_0000401454"
FT PEPTIDE 104..116
FT /note="GLV6p"
FT /id="PRO_0000401455"
FT PROPEP 117..123
FT /evidence="ECO:0000250|UniProtKB:Q3E880"
FT /id="PRO_0000401456"
FT REGION 61..92
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 61..75
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 76..92
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 105
FT /note="Sulfotyrosine"
FT /evidence="ECO:0000250|UniProtKB:Q3E880"
FT MOD_RES 113
FT /note="Hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:O49519"
SQ SEQUENCE 123 AA; 13969 MW; 42636762954DB2E9 CRC64;
MKLIRVTLFL CALAILLLVT PTSSLQLKHP YSSPSQGLSK KIVTKMATRK LMIISSEYVM
TSTSHEGSSE QLRVTSSGKS KDEEKKLSEE EEEKKALAKY LSMDYRTFRR RRPVHNKALP
LDP
