GLV7_ARATH
ID GLV7_ARATH Reviewed; 110 AA.
AC Q6ID76; Q8S8B2;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Protein GOLVEN 7 {ECO:0000303|PubMed:23370719};
DE AltName: Full=CLAVATA3/ESR (CLE)-related protein CLEL3 {ECO:0000303|PubMed:22307643};
DE Short=CLE-Like protein 3 {ECO:0000303|PubMed:22307643};
DE AltName: Full=Root meristem growth factor 3 {ECO:0000303|PubMed:20798316};
DE Short=AtRGF3 {ECO:0000303|PubMed:20798316};
DE Contains:
DE RecName: Full=GLV7p {ECO:0000303|PubMed:23370719};
DE Flags: Precursor;
GN Name=GLV7 {ECO:0000303|PubMed:23370719};
GN Synonyms=CLEL3 {ECO:0000303|PubMed:22307643},
GN RGF3 {ECO:0000303|PubMed:20798316};
GN OrderedLocusNames=At2g04025 {ECO:0000312|Araport:AT2G04025};
GN ORFNames=F3C11.1 {ECO:0000312|EMBL:AAM15430.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Cheuk R.F., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE,
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=20798316; DOI=10.1126/science.1191132;
RA Matsuzaki Y., Ogawa-Ohnishi M., Mori A., Matsubayashi Y.;
RT "Secreted peptide signals required for maintenance of root stem cell niche
RT in Arabidopsis.";
RL Science 329:1065-1067(2010).
RN [5]
RP TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, NOMENCLATURE, AND GENE FAMILY.
RC STRAIN=cv. Columbia;
RX PubMed=22307643; DOI=10.1073/pnas.1119864109;
RA Meng L., Buchanan B.B., Feldman L.J., Luan S.;
RT "CLE-like (CLEL) peptides control the pattern of root growth and lateral
RT root development in Arabidopsis.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:1760-1765(2012).
RN [6]
RP FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC STRAIN=cv. Columbia;
RX PubMed=23370719; DOI=10.1104/pp.112.206029;
RA Fernandez A., Drozdzecki A., Hoogewijs K., Nguyen A., Beeckman T.,
RA Madder A., Hilson P.;
RT "Transcriptional and functional classification of the GOLVEN/ROOT GROWTH
RT FACTOR/CLE-like signaling peptides reveals their role in lateral root and
RT hair formation.";
RL Plant Physiol. 161:954-970(2013).
RN [7]
RP INTERACTION WITH RGI1; RGI2 AND RGI3.
RC STRAIN=cv. Columbia;
RX PubMed=27001831; DOI=10.1073/pnas.1522639113;
RA Shinohara H., Mori A., Yasue N., Sumida K., Matsubayashi Y.;
RT "Identification of three LRR-RKs involved in perception of root meristem
RT growth factor in Arabidopsis.";
RL Proc. Natl. Acad. Sci. U.S.A. 113:3897-3902(2016).
RN [8]
RP X-RAY CRYSTALLOGRAPHY (2.59 ANGSTROMS) OF 98-110.
RA Song W., Han Z., Chai J.;
RT "Plant Receptor.";
RL Submitted (FEB-2016) to the PDB data bank.
CC -!- FUNCTION: [GLV7p]: Signaling peptide (root growth factor) that
CC maintains the postembryonic root stem cell niche (PubMed:20798316,
CC PubMed:23370719). Regulates the pattern of root growth and lateral root
CC development by modulating the length and the number of cortical cells
CC in the root apical meristem (RAM), and the anticlinal asymmetric cell
CC divisions in lateral root initiation cells (By similarity).
CC {ECO:0000250|UniProtKB:Q93VK8, ECO:0000269|PubMed:20798316,
CC ECO:0000269|PubMed:23370719}.
CC -!- SUBUNIT: [GLV7p]: Binds to LRR receptor-like serine/threonine-protein
CC kinases RGI1, RGI2 and RGI3 to trigger their dimerization with SERK
CC proteins and subsequent signaling. {ECO:0000269|PubMed:27001831}.
CC -!- SUBCELLULAR LOCATION: [GLV7p]: Secreted {ECO:0000250|UniProtKB:Q3E880}.
CC -!- TISSUE SPECIFICITY: Expressed in root tips (PubMed:20798316,
CC PubMed:22307643, PubMed:23370719). Also present in siliques
CC (PubMed:22307643). {ECO:0000269|PubMed:20798316,
CC ECO:0000269|PubMed:22307643, ECO:0000269|PubMed:23370719}.
CC -!- DEVELOPMENTAL STAGE: In roots, expressed only in the quiescent center
CC (QC), the columella stem cells (CC) and the innermost layer of central
CC columella cells; mostly present in the third and fourth CC layers, but
CC not, or only marginally, in the QC (PubMed:20798316, PubMed:22307643,
CC PubMed:23370719). Induced during lateral root formation
CC (PubMed:23370719). Accumulates in pollen grains (PubMed:23370719).
CC {ECO:0000269|PubMed:20798316, ECO:0000269|PubMed:22307643,
CC ECO:0000269|PubMed:23370719}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype, due to the redundancy with
CC other RGF genes. Triple mutant rgf1-rgf2-rgf3 shows a decreased
CC meristematic cell number resulting in a short root phenotype.
CC {ECO:0000269|PubMed:20798316}.
CC -!- MISCELLANEOUS: 'Golven' means irregular waves in Dutch.
CC {ECO:0000305|PubMed:23370719}.
CC -!- SIMILARITY: Belongs to the RGF family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM15430.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC007167; AAM15430.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC05777.1; -; Genomic_DNA.
DR EMBL; BT014797; AAT41780.1; -; mRNA.
DR EMBL; BT015692; AAU29469.1; -; mRNA.
DR RefSeq; NP_001324399.1; NM_001335213.1.
DR RefSeq; NP_178486.2; NM_126438.3.
DR PDB; 5HZ1; X-ray; 2.59 A; A=98-110.
DR PDBsum; 5HZ1; -.
DR AlphaFoldDB; Q6ID76; -.
DR SMR; Q6ID76; -.
DR STRING; 3702.AT2G04025.1; -.
DR PaxDb; Q6ID76; -.
DR PRIDE; Q6ID76; -.
DR EnsemblPlants; AT2G04025.1; AT2G04025.1; AT2G04025.
DR GeneID; 814929; -.
DR Gramene; AT2G04025.1; AT2G04025.1; AT2G04025.
DR KEGG; ath:AT2G04025; -.
DR Araport; AT2G04025; -.
DR TAIR; locus:2827444; AT2G04025.
DR eggNOG; ENOG502R1TA; Eukaryota.
DR HOGENOM; CLU_175812_0_0_1; -.
DR InParanoid; Q6ID76; -.
DR OMA; MIANGKE; -.
DR OrthoDB; 1579296at2759; -.
DR PhylomeDB; Q6ID76; -.
DR PRO; PR:Q6ID76; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q6ID76; baseline and differential.
DR Genevisible; Q6ID76; AT.
DR GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR GO; GO:0008083; F:growth factor activity; IDA:UniProtKB.
DR GO; GO:0030154; P:cell differentiation; IDA:UniProtKB.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IDA:UniProtKB.
DR GO; GO:0010628; P:positive regulation of gene expression; IEP:TAIR.
DR GO; GO:0009786; P:regulation of asymmetric cell division; ISS:UniProtKB.
DR GO; GO:2000023; P:regulation of lateral root development; ISS:UniProtKB.
DR GO; GO:0010082; P:regulation of root meristem growth; IGI:TAIR.
DR GO; GO:2000067; P:regulation of root morphogenesis; ISS:UniProtKB.
DR InterPro; IPR038804; RGF1/2/3.
DR PANTHER; PTHR36313; PTHR36313; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Differentiation; Growth factor; Hydroxylation;
KW Reference proteome; Secreted; Signal; Sulfation.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT PROPEP 24..97
FT /evidence="ECO:0000250|UniProtKB:Q3E880"
FT /id="PRO_0000401442"
FT PEPTIDE 98..110
FT /note="GLV7p"
FT /id="PRO_0000401443"
FT REGION 59..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..87
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 99
FT /note="Sulfotyrosine"
FT /evidence="ECO:0000250|UniProtKB:Q3E880"
FT MOD_RES 107
FT /note="Hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:O49519"
SQ SEQUENCE 110 AA; 12647 MW; 4021655BEB2FE3BE CRC64;
MTTLSKILCV LIILLLCFSF RYSLHEDGNQ QSSRDFVSTA KAIKYGDVMK KMIRGRKLMM
ASGEKEEAET KMKRGNRETE RNSSKSVEED GLVAYTADYW RAKHHPPKNN
