GLV8_ARATH
ID GLV8_ARATH Reviewed; 111 AA.
AC B3H5Q2;
DT 25-OCT-2017, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 1.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=Protein GOLVEN 8 {ECO:0000303|PubMed:23370719};
DE AltName: Full=CLAVATA3/ESR (CLE)-related protein CLEL5 {ECO:0000303|PubMed:22307643};
DE Short=CLE-Like protein 5 {ECO:0000303|PubMed:22307643};
DE Contains:
DE RecName: Full=GLV8p {ECO:0000303|PubMed:23370719};
DE Flags: Precursor;
GN Name=GLV8 {ECO:0000303|PubMed:23370719};
GN Synonyms=CLEL5 {ECO:0000303|PubMed:22307643};
GN OrderedLocusNames=At3g02242 {ECO:0000312|Araport:AT3G02242};
GN ORFNames=F14P3 {ECO:0000305};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NOMENCLATURE, AND GENE FAMILY.
RX PubMed=22307643; DOI=10.1073/pnas.1119864109;
RA Meng L., Buchanan B.B., Feldman L.J., Luan S.;
RT "CLE-like (CLEL) peptides control the pattern of root growth and lateral
RT root development in Arabidopsis.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:1760-1765(2012).
RN [4]
RP FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RC STRAIN=cv. Columbia;
RX PubMed=23370719; DOI=10.1104/pp.112.206029;
RA Fernandez A., Drozdzecki A., Hoogewijs K., Nguyen A., Beeckman T.,
RA Madder A., Hilson P.;
RT "Transcriptional and functional classification of the GOLVEN/ROOT GROWTH
RT FACTOR/CLE-like signaling peptides reveals their role in lateral root and
RT hair formation.";
RL Plant Physiol. 161:954-970(2013).
CC -!- FUNCTION: [GLV8p]: Signaling peptide (root growth factor) that promotes
CC root hairs formation and growth (PubMed:23370719). Regulates the
CC pattern of root growth and lateral root development by modulating the
CC length and the number of cortical cells in the root apical meristem
CC (RAM), and the anticlinal asymmetric cell divisions in lateral root
CC initiation cells (By similarity). {ECO:0000250|UniProtKB:Q93VK8,
CC ECO:0000269|PubMed:23370719}.
CC -!- SUBUNIT: [GLV8p]: Binds to LRR receptor-like serine/threonine-protein
CC kinases to trigger their dimerization with SERK proteins and subsequent
CC signaling. {ECO:0000250|UniProtKB:Q9LI64}.
CC -!- SUBCELLULAR LOCATION: [GLV8p]: Secreted {ECO:0000250|UniProtKB:Q3E880}.
CC -!- TISSUE SPECIFICITY: Expressed in the root portion above the meristem,
CC in sepals and pollen grains, and in cotyledons and leaves lamina,
CC stipules and petioles. {ECO:0000269|PubMed:23370719}.
CC -!- DEVELOPMENTAL STAGE: In primary roots and mature lateral roots (LRs),
CC expressed in cortex and epidermis from the border of the maturation
CC zone up to the colet (PubMed:23370719). Restricted to the nonhair cell
CC files in the epidermis, but present in all cortical cells regardless of
CC their position (PubMed:23370719). Induced during lateral root formation
CC in mature lateral roots (PubMed:23370719). Patchy expression in
CC cotyledons and leaves, but accumulates at the base of the cotyledon
CC petioles and in stipules (PubMed:23370719). In flowers, irregular
CC repartition in the sepals and pollen grains (PubMed:23370719).
CC {ECO:0000269|PubMed:23370719}.
CC -!- PTM: The tyrosine sulfation is critical for the function of the
CC peptide. {ECO:0000250|UniProtKB:Q3E880}.
CC -!- DISRUPTION PHENOTYPE: Shorter and fewer root hairs.
CC {ECO:0000269|PubMed:23370719}.
CC -!- MISCELLANEOUS: 'Golven' means irregular waves in Dutch.
CC {ECO:0000305|PubMed:23370719}.
CC -!- SIMILARITY: Belongs to the RGF family. {ECO:0000305}.
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DR EMBL; AC009755; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002686; AEE73783.1; -; Genomic_DNA.
DR RefSeq; NP_001118555.1; NM_001125083.2.
DR AlphaFoldDB; B3H5Q2; -.
DR STRING; 3702.AT3G02242.1; -.
DR iPTMnet; B3H5Q2; -.
DR PaxDb; B3H5Q2; -.
DR PRIDE; B3H5Q2; -.
DR EnsemblPlants; AT3G02242.1; AT3G02242.1; AT3G02242.
DR GeneID; 6240491; -.
DR Gramene; AT3G02242.1; AT3G02242.1; AT3G02242.
DR KEGG; ath:AT3G02242; -.
DR Araport; AT3G02242; -.
DR TAIR; locus:4515103012; AT3G02242.
DR HOGENOM; CLU_2187525_0_0_1; -.
DR OMA; SLKMINP; -.
DR OrthoDB; 1612168at2759; -.
DR PhylomeDB; B3H5Q2; -.
DR PRO; PR:B3H5Q2; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; B3H5Q2; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0009786; P:regulation of asymmetric cell division; ISS:UniProtKB.
DR GO; GO:2000023; P:regulation of lateral root development; ISS:UniProtKB.
DR GO; GO:0010082; P:regulation of root meristem growth; ISS:UniProtKB.
DR GO; GO:2000067; P:regulation of root morphogenesis; ISS:UniProtKB.
DR GO; GO:0080147; P:root hair cell development; IMP:UniProtKB.
DR GO; GO:0048766; P:root hair initiation; IMP:UniProtKB.
PE 2: Evidence at transcript level;
KW Differentiation; Growth factor; Hydroxylation; Reference proteome;
KW Secreted; Signal; Sulfation.
FT SIGNAL 1..32
FT /evidence="ECO:0000255"
FT PROPEP 33..96
FT /evidence="ECO:0000250|UniProtKB:Q3E880"
FT /id="PRO_0000441866"
FT PEPTIDE 97..111
FT /note="GLV8p"
FT /evidence="ECO:0000250|UniProtKB:Q3E880"
FT /id="PRO_0000441867"
FT MOD_RES 98
FT /note="Sulfotyrosine"
FT /evidence="ECO:0000250|UniProtKB:Q3E880"
FT MOD_RES 107
FT /note="Hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:O49519"
SQ SEQUENCE 111 AA; 12671 MW; 0F87988C6CE12593 CRC64;
MKKWSYAKLM TSALLLVFLS IILLAFHGGS RGDNHLYDHV AIGTKDILMG RKLKDLKPKT
ESLKMINPKK KNGFEYSDQV SSDLSRQEVF VDMMARDYQG PKPRSKPLKN N
