GLV9_ARATH
ID GLV9_ARATH Reviewed; 95 AA.
AC F4KB79;
DT 10-FEB-2021, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 58.
DE RecName: Full=Protein GOLVEN 9 {ECO:0000303|PubMed:23370719};
DE Contains:
DE RecName: Full=GLV9p {ECO:0000303|PubMed:23370719};
DE Flags: Precursor;
GN Name=GLV9 {ECO:0000303|PubMed:23370719};
GN OrderedLocusNames=At5g15725 {ECO:0000312|Araport:AT5G15725};
GN ORFNames=F14F8 {ECO:0000312|EMBL:AL391144};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC STRAIN=cv. Columbia;
RX PubMed=23370719; DOI=10.1104/pp.112.206029;
RA Fernandez A., Drozdzecki A., Hoogewijs K., Nguyen A., Beeckman T.,
RA Madder A., Hilson P.;
RT "Transcriptional and functional classification of the GOLVEN/ROOT GROWTH
RT FACTOR/CLE-like signaling peptides reveals their role in lateral root and
RT hair formation.";
RL Plant Physiol. 161:954-970(2013).
CC -!- FUNCTION: [GLV9p]: Signaling peptide (root growth factor) required
CC during root gravitropism in a PIN2-traffic dependent manner
CC (PubMed:23370719). Regulates the pattern of root growth and lateral
CC root development by modulating the length and the number of cortical
CC cells in the root apical meristem (RAM), and the anticlinal asymmetric
CC cell divisions in lateral root initiation cells (PubMed:23370719).
CC {ECO:0000269|PubMed:23370719}.
CC -!- SUBUNIT: [GLV9p]: Binds to LRR receptor-like serine/threonine-protein
CC kinases to trigger their dimerization with SERK proteins and subsequent
CC signaling. {ECO:0000250|UniProtKB:Q9LI64}.
CC -!- SUBCELLULAR LOCATION: [GLV9p]: Secreted {ECO:0000250|UniProtKB:Q3E880}.
CC -!- TISSUE SPECIFICITY: Expressed in roots. {ECO:0000269|PubMed:23370719}.
CC -!- DEVELOPMENTAL STAGE: In roots, restricted to the root apical meristem
CC (RAM) in a pattern positioned just above the quiescent center (QC);
CC strongest levels are observed in the meristematic cortical cells, but
CC also detected in the epidermis and within the vasculature
CC (PubMed:23370719). Induced during lateral root formation after the
CC emergence of the primordium (PubMed:23370719).
CC {ECO:0000269|PubMed:23370719}.
CC -!- MISCELLANEOUS: 'Golven' means irregular waves in Dutch.
CC {ECO:0000305|PubMed:23370719}.
CC -!- SIMILARITY: Belongs to the RGF family. {ECO:0000305}.
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DR EMBL; AL391144; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002688; AED92197.1; -; Genomic_DNA.
DR RefSeq; NP_568319.1; NM_121577.4.
DR AlphaFoldDB; F4KB79; -.
DR STRING; 3702.AT5G15725.1; -.
DR PaxDb; F4KB79; -.
DR PRIDE; F4KB79; -.
DR EnsemblPlants; AT5G15725.1; AT5G15725.1; AT5G15725.
DR GeneID; 831428; -.
DR Gramene; AT5G15725.1; AT5G15725.1; AT5G15725.
DR KEGG; ath:AT5G15725; -.
DR Araport; AT5G15725; -.
DR TAIR; locus:505006618; AT5G15725.
DR HOGENOM; CLU_2375704_0_0_1; -.
DR OMA; RTPVHNG; -.
DR OrthoDB; 1610013at2759; -.
DR PhylomeDB; F4KB79; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; F4KB79; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0009958; P:positive gravitropism; IMP:TAIR.
PE 2: Evidence at transcript level;
KW Differentiation; Growth factor; Hydroxylation; Reference proteome;
KW Secreted; Signal; Sulfation.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT PROPEP 25..73
FT /evidence="ECO:0000250|UniProtKB:Q3E880"
FT /id="PRO_0000451981"
FT PEPTIDE 74..89
FT /note="GLV9p"
FT /id="PRO_0000451982"
FT PROPEP 90..95
FT /evidence="ECO:0000250|UniProtKB:Q3E880"
FT /id="PRO_0000451983"
FT REGION 72..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 75
FT /note="Sulfotyrosine"
FT /evidence="ECO:0000250|UniProtKB:Q3E880"
FT MOD_RES 86
FT /note="Hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:O49519"
SQ SEQUENCE 95 AA; 10812 MW; 1CD6E956FCE390EF CRC64;
MKKTSLKLMT LVLGFCFVIY LLQGPRGGSR NGDLLIARKL ISLEPIETKN AARSLKDSIS
TDLEEEVDRL MEHEYPSPVK PRKRTPVHNG VRNRH
