GLVR_BACSU
ID GLVR_BACSU Reviewed; 254 AA.
AC P54717;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=HTH-type transcriptional regulator GlvR;
DE AltName: Full=Glv operon regulatory protein;
GN Name=glvR; Synonyms=yfiA; OrderedLocusNames=BSU08190;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX PubMed=8704981; DOI=10.1099/13500872-142-6-1417;
RA Yamamoto H., Uchiyama S., Fajar A.N., Ogasawara N., Sekiguchi J.;
RT "Determination of a 12 kb nucleotide sequence around the 76 degrees region
RT of the Bacillus subtilis chromosome.";
RL Microbiology 142:1417-1421(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [3]
RP FUNCTION.
RX PubMed=11489864; DOI=10.1128/jb.183.17.5110-5121.2001;
RA Yamamoto H., Serizawa M., Thompson J., Sekiguchi J.;
RT "Regulation of the glv operon in Bacillus subtilis: YfiA (GlvR) is a
RT positive regulator of the operon that is repressed through CcpA and cre.";
RL J. Bacteriol. 183:5110-5121(2001).
CC -!- FUNCTION: Positive regulator of the glv operon expression, which
CC consists of GlvA, GlvR and GlvC. {ECO:0000269|PubMed:11489864}.
CC -!- INDUCTION: By maltose; repressed by glucose.
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DR EMBL; D50543; BAA09104.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB12648.1; -; Genomic_DNA.
DR PIR; D69802; D69802.
DR RefSeq; NP_388700.1; NC_000964.3.
DR RefSeq; WP_003233607.1; NZ_JNCM01000032.1.
DR AlphaFoldDB; P54717; -.
DR SMR; P54717; -.
DR STRING; 224308.BSU08190; -.
DR PaxDb; P54717; -.
DR PRIDE; P54717; -.
DR EnsemblBacteria; CAB12648; CAB12648; BSU_08190.
DR GeneID; 939205; -.
DR KEGG; bsu:BSU08190; -.
DR PATRIC; fig|224308.179.peg.885; -.
DR eggNOG; COG1737; Bacteria.
DR InParanoid; P54717; -.
DR OMA; WHCKQLL; -.
DR PhylomeDB; P54717; -.
DR BioCyc; BSUB:BSU08190-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0097367; F:carbohydrate derivative binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:1901135; P:carbohydrate derivative metabolic process; IEA:InterPro.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR CDD; cd05013; SIS_RpiR; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR000281; HTH_RpiR.
DR InterPro; IPR035472; RpiR-like_SIS.
DR InterPro; IPR001347; SIS_dom.
DR InterPro; IPR046348; SIS_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR Pfam; PF01418; HTH_6; 1.
DR Pfam; PF01380; SIS; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF53697; SSF53697; 1.
DR PROSITE; PS51071; HTH_RPIR; 1.
DR PROSITE; PS51464; SIS; 1.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..254
FT /note="HTH-type transcriptional regulator GlvR"
FT /id="PRO_0000068622"
FT DOMAIN 1..77
FT /note="HTH rpiR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00390"
FT DOMAIN 106..248
FT /note="SIS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00797"
FT DNA_BIND 37..56
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00390"
SQ SEQUENCE 254 AA; 29298 MW; 09E2BD81B8E23E37 CRC64;
MQLEELINQH YSKLNDNDFH ILKYILNHKH TCYHLGIDAL AKACSVSRSS ILRLAQKLGF
SGYSEFRVFL KWEDQPEEGE SMSFEKLLDD IEANLKFLRT KDMTDMCQLI DAADRIFVYG
SGNAQKICAR DLQRMFIPRH RYLILIEDTN EFNLMRDDFK VNDLFIIISL SGETPELIPQ
ARMLSAKGIP FISITNLKNN VLAQLTPHNL YATSKPVTLS DRTEIVAFAP FFLVGEALFR
AYVDYKEAEK NDNE
