GLYAL_MOUSE
ID GLYAL_MOUSE Reviewed; 296 AA.
AC Q5FW57; E9QNP7;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 3.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Glycine N-acyltransferase-like protein;
DE EC=2.3.1.13;
DE AltName: Full=Acyl-CoA:glycine N-acyltransferase-like;
DE Short=AAc-like;
GN Name=Gm4952;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-41; LYS-48; LYS-183 AND
RP LYS-256, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001;
RA Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y.,
RA Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.;
RT "SIRT5-mediated lysine desuccinylation impacts diverse metabolic
RT pathways.";
RL Mol. Cell 50:919-930(2013).
RN [4]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-41; LYS-43; LYS-48; LYS-80;
RP LYS-83; LYS-183 AND LYS-256, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE
RP SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=23576753; DOI=10.1073/pnas.1302961110;
RA Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B.,
RA Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.;
RT "Label-free quantitative proteomics of the lysine acetylome in mitochondria
RT identifies substrates of SIRT3 in metabolic pathways.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013).
CC -!- FUNCTION: Mitochondrial acyltransferase which transfers the acyl group
CC to the N-terminus of glycine. Can conjugate a multitude of substrates
CC to form a variety of N-acylglycines (By similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an acyl-CoA + glycine = an N-acylglycine + CoA + H(+);
CC Xref=Rhea:RHEA:19869, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57305, ChEBI:CHEBI:57670, ChEBI:CHEBI:58342; EC=2.3.1.13;
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the glycine N-acyltransferase family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH89619.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC129014; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC089619; AAH89619.1; ALT_SEQ; mRNA.
DR CCDS; CCDS50398.1; -.
DR RefSeq; NP_001013784.2; NM_001013762.2.
DR RefSeq; NP_001161379.1; NM_001167907.1.
DR AlphaFoldDB; Q5FW57; -.
DR SMR; Q5FW57; -.
DR STRING; 10090.ENSMUSP00000090607; -.
DR iPTMnet; Q5FW57; -.
DR PhosphoSitePlus; Q5FW57; -.
DR jPOST; Q5FW57; -.
DR MaxQB; Q5FW57; -.
DR PaxDb; Q5FW57; -.
DR PeptideAtlas; Q5FW57; -.
DR PRIDE; Q5FW57; -.
DR ProteomicsDB; 271236; -.
DR DNASU; 240549; -.
DR Ensembl; ENSMUST00000092931; ENSMUSP00000090607; ENSMUSG00000071633.
DR GeneID; 240549; -.
DR KEGG; mmu:240549; -.
DR UCSC; uc008gug.2; mouse.
DR MGI; MGI:3643569; Gm4952.
DR VEuPathDB; HostDB:ENSMUSG00000071633; -.
DR eggNOG; ENOG502SDQB; Eukaryota.
DR GeneTree; ENSGT00950000183133; -.
DR InParanoid; Q5FW57; -.
DR OMA; NLACILY; -.
DR OrthoDB; 1221333at2759; -.
DR PhylomeDB; Q5FW57; -.
DR TreeFam; TF353258; -.
DR BioGRID-ORCS; 240549; 0 hits in 65 CRISPR screens.
DR ChiTaRS; Gm4952; mouse.
DR PRO; PR:Q5FW57; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q5FW57; protein.
DR Bgee; ENSMUSG00000071633; Expressed in liver and 20 other tissues.
DR ExpressionAtlas; Q5FW57; baseline and differential.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0047961; F:glycine N-acyltransferase activity; IBA:GO_Central.
DR GO; GO:0047962; F:glycine N-benzoyltransferase activity; IBA:GO_Central.
DR GO; GO:0016410; F:N-acyltransferase activity; IBA:GO_Central.
DR GO; GO:0006544; P:glycine metabolic process; IBA:GO_Central.
DR InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR InterPro; IPR010313; Glycine_N-acyltransferase.
DR InterPro; IPR013652; Glycine_N-acyltransferase_C.
DR InterPro; IPR015938; Glycine_N-acyltransferase_N.
DR PANTHER; PTHR15298; PTHR15298; 1.
DR Pfam; PF08444; Gly_acyl_tr_C; 1.
DR Pfam; PF06021; Gly_acyl_tr_N; 1.
DR SUPFAM; SSF55729; SSF55729; 1.
PE 1: Evidence at protein level;
KW Acetylation; Acyltransferase; Mitochondrion; Reference proteome;
KW Transferase.
FT CHAIN 1..296
FT /note="Glycine N-acyltransferase-like protein"
FT /id="PRO_0000281878"
FT MOD_RES 41
FT /note="N6-acetyllysine; alternate"
FT /evidence="ECO:0007744|PubMed:23576753"
FT MOD_RES 41
FT /note="N6-succinyllysine; alternate"
FT /evidence="ECO:0007744|PubMed:23806337"
FT MOD_RES 43
FT /note="N6-acetyllysine"
FT /evidence="ECO:0007744|PubMed:23576753"
FT MOD_RES 48
FT /note="N6-acetyllysine; alternate"
FT /evidence="ECO:0007744|PubMed:23576753"
FT MOD_RES 48
FT /note="N6-succinyllysine; alternate"
FT /evidence="ECO:0007744|PubMed:23806337"
FT MOD_RES 80
FT /note="N6-acetyllysine"
FT /evidence="ECO:0007744|PubMed:23576753"
FT MOD_RES 83
FT /note="N6-acetyllysine"
FT /evidence="ECO:0007744|PubMed:23576753"
FT MOD_RES 183
FT /note="N6-acetyllysine; alternate"
FT /evidence="ECO:0007744|PubMed:23576753"
FT MOD_RES 183
FT /note="N6-succinyllysine; alternate"
FT /evidence="ECO:0007744|PubMed:23806337"
FT MOD_RES 256
FT /note="N6-acetyllysine; alternate"
FT /evidence="ECO:0007744|PubMed:23576753"
FT MOD_RES 256
FT /note="N6-succinyllysine; alternate"
FT /evidence="ECO:0007744|PubMed:23806337"
FT CONFLICT 152
FT /note="Y -> C (in Ref. 1; AAH89619)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 296 AA; 34168 MW; E6BB9884C85BBC6F CRC64;
MLHLRSSQML QMLESSLRKY LPESLKVYGT VFHMNQGNPF KLKALVDKWP DFNTVVVRPR
EQEMGDDLDQ HTNTYQIYSK DPKHCLEFLG TPDVINWKQH LQIQSSQSNL NEAIMDLAAG
KMVKVKRTQC ILYMMPETAK KLVPSLLEDK EYLDHQSGRP RAIDQEMFKL STLDVTHAPL
VDKFWQFGGN ERSQRFIGRC IQIFPSSCLL GPEGTPVSWA LMDQTGEIRM AGTVPDYRAQ
GLISHIIYAQ TLAMDKRGYP VYNHTEQTNK VIQKMSHTLH HVPMPCDWNQ WYCAPL
