AML2_ARATH
ID AML2_ARATH Reviewed; 843 AA.
AC Q9SJG8; Q8S8G0; Q9ASS1; Q9SEU3;
DT 31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 2.
DT 25-MAY-2022, entry version 134.
DE RecName: Full=Protein MEI2-like 2;
DE Short=AML2;
DE AltName: Full=MEI2-like protein 2;
GN Name=ML2; Synonyms=MEI2; OrderedLocusNames=At2g42890; ORFNames=F7D19.11;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Columbia;
RA Bourdon V., Tinland B.;
RT "Isolation and characterization of MEI2, the Arabidopsis homolog of the
RT Schizosaccharomyces pombe mei2 gene.";
RL Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP GENE FAMILY, AND DEVELOPMENTAL STAGE.
RX PubMed=15356386; DOI=10.1023/b:plan.0000040819.33383.b6;
RA Anderson G.H., Alvarez N.D., Gilman C., Jeffares D.C., Trainor V.C.,
RA Hanson M.R., Veit B.;
RT "Diversification of genes encoding mei2 -like RNA binding proteins in
RT plants.";
RL Plant Mol. Biol. 54:653-670(2004).
RN [6]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=15720729; DOI=10.1186/1471-2229-5-2;
RA Anderson G.H., Hanson M.R.;
RT "The Arabidopsis Mei2 homologue AML1 binds AtRaptor1B, the plant homologue
RT of a major regulator of eukaryotic cell growth.";
RL BMC Plant Biol. 5:2-2(2005).
RN [7]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=16473967; DOI=10.1105/tpc.105.039156;
RA Kaur J., Sebastian J., Siddiqi I.;
RT "The Arabidopsis-mei2-like genes play a role in meiosis and vegetative
RT growth in Arabidopsis.";
RL Plant Cell 18:545-559(2006).
CC -!- FUNCTION: Probable RNA-binding protein that plays a role in meiosis and
CC vegetative growth. {ECO:0000269|PubMed:15720729,
CC ECO:0000269|PubMed:16473967}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q9SJG8-1; Sequence=Displayed;
CC -!- DEVELOPMENTAL STAGE: Expressed in the embryo at the heart and torpedo
CC stages. Highly expressed throughout the vegetative shoot apex.
CC {ECO:0000269|PubMed:15356386}.
CC -!- DISRUPTION PHENOTYPE: Early flowering. {ECO:0000269|PubMed:15720729}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF21885.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305};
CC Sequence=AAM15289.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AF101056; AAF21885.1; ALT_SEQ; mRNA.
DR EMBL; AC006580; AAM15289.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC006931; AAD21720.2; -; Genomic_DNA.
DR EMBL; CP002685; AEC10182.1; -; Genomic_DNA.
DR EMBL; AF367316; AAK32903.1; -; mRNA.
DR EMBL; AY143940; AAN28879.1; -; mRNA.
DR PIR; E84859; E84859.
DR RefSeq; NP_565990.1; NM_129850.4. [Q9SJG8-1]
DR AlphaFoldDB; Q9SJG8; -.
DR SMR; Q9SJG8; -.
DR STRING; 3702.AT2G42890.1; -.
DR iPTMnet; Q9SJG8; -.
DR PaxDb; Q9SJG8; -.
DR PRIDE; Q9SJG8; -.
DR ProteomicsDB; 245049; -. [Q9SJG8-1]
DR EnsemblPlants; AT2G42890.1; AT2G42890.1; AT2G42890. [Q9SJG8-1]
DR GeneID; 818890; -.
DR Gramene; AT2G42890.1; AT2G42890.1; AT2G42890. [Q9SJG8-1]
DR KEGG; ath:AT2G42890; -.
DR Araport; AT2G42890; -.
DR TAIR; locus:2045605; AT2G42890.
DR eggNOG; KOG4660; Eukaryota.
DR InParanoid; Q9SJG8; -.
DR OMA; ICDISYA; -.
DR PhylomeDB; Q9SJG8; -.
DR PRO; PR:Q9SJG8; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9SJG8; baseline and differential.
DR Genevisible; Q9SJG8; AT.
DR GO; GO:0016607; C:nuclear speck; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR GO; GO:0045927; P:positive regulation of growth; IMP:UniProtKB.
DR GO; GO:0045836; P:positive regulation of meiotic nuclear division; IMP:UniProtKB.
DR CDD; cd12524; RRM1_MEI2_like; 1.
DR CDD; cd12531; RRM3_MEI2_like; 1.
DR Gene3D; 3.30.70.330; -; 2.
DR InterPro; IPR034453; MEI2-like_RRM1.
DR InterPro; IPR034454; MEI2-like_RRM3.
DR InterPro; IPR007201; Mei2-like_Rrm_C.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR Pfam; PF00076; RRM_1; 2.
DR Pfam; PF04059; RRM_2; 1.
DR SMART; SM00360; RRM; 2.
DR SUPFAM; SSF54928; SSF54928; 2.
DR PROSITE; PS50102; RRM; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Meiosis; Reference proteome; Repeat; RNA-binding.
FT CHAIN 1..843
FT /note="Protein MEI2-like 2"
FT /id="PRO_0000409342"
FT DOMAIN 198..271
FT /note="RRM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 283..356
FT /note="RRM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
SQ SEQUENCE 843 AA; 93215 MW; E8FBB35D4899DB45 CRC64;
MVSSIIAVAE GKKMELEPNK SLSADMPSLL SRSSEAFNGG TGYRSSSDLS MFSSSLPTLF
HEKLNMTDSD SWLSFDESSP NLNKLVIGNS EKDSLEDVEP DALEILLPED ENELLPGLID
ELNFTGLPDE LDDLEECDVF CTGGGMELDV ESQDNHAVDA SGMQISDRGA ANAFVPRKRP
NTAGRVSVEH PNGEHPSRTL FVRNINSSVE DSELSALFEP FGEIRSLYTA CKSRGFVMIS
YYDIRAAHAA MRALQNTLLR KRTLDIHFSI PKENPSEKDM NQGTLVIFNV DTTVSNDELL
QLFGAYGEIR EIRETPNRRF HRFIEYYDVR DAETALKALN RSEIGGKCIK LELSRPGGAR
RLSVPSQSQD LERTEVTNFY NQVGSHVANS PPGNWPIGSP VKGSPSHAFT RPHGLGMVRP
VNSDNMPGLA SILPAHPSSF HGFSPVSNDQ GLLNHSNQTI LNKGLMHNIS YGQPHSLPEH
ITGGISNSMR FIAPHSSGFG TSSDHRYRWG SPPQHMNYPG YTGVSSSSSS TERPFTVRHG
FPFAERQASL LGKYQHHVGS APSSIHFNTQ MNCYTGSPEI PLGFSDMGIN RNYNSAHGKA
NLGVSLPGNS SEQDFTGFGM SSMPTVPFGG SRGLQSVRPE PFAEQGRIHN HESHNQNQFI
DGGRYHIDLD RIASGDEIRT TLIIKNIPNK YTYKMLVAEI DEKHKGDYDF LCLPTDFKNK
CNMGHAFINM VSPLHIVPFQ QTFNGKIWEK FNSGKVASLA YAEIQGKSAL ASYMQTPSSM
KEQKQLFPEV SYHDDGQDAN DHEQLFSSIW NITAPDSDWS YTMDLIENPR ENGNSKNAAE
ESS
