AML3_ARATH
ID AML3_ARATH Reviewed; 759 AA.
AC Q9SVV9; C0Z3B0; F4JQR3;
DT 31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 31-MAY-2011, sequence version 2.
DT 25-MAY-2022, entry version 123.
DE RecName: Full=Protein MEI2-like 3;
DE Short=AML3;
DE AltName: Full=MEI2-like protein 3;
GN Name=ML3; OrderedLocusNames=At4g18120; ORFNames=F15J5.90;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=19423640; DOI=10.1093/dnares/dsp009;
RA Iida K., Fukami-Kobayashi K., Toyoda A., Sakaki Y., Kobayashi M., Seki M.,
RA Shinozaki K.;
RT "Analysis of multiple occurrences of alternative splicing events in
RT Arabidopsis thaliana using novel sequenced full-length cDNAs.";
RL DNA Res. 16:155-164(2009).
RN [4]
RP GENE FAMILY, AND DEVELOPMENTAL STAGE.
RX PubMed=15356386; DOI=10.1023/b:plan.0000040819.33383.b6;
RA Anderson G.H., Alvarez N.D., Gilman C., Jeffares D.C., Trainor V.C.,
RA Hanson M.R., Veit B.;
RT "Diversification of genes encoding mei2 -like RNA binding proteins in
RT plants.";
RL Plant Mol. Biol. 54:653-670(2004).
RN [5]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=15720729; DOI=10.1186/1471-2229-5-2;
RA Anderson G.H., Hanson M.R.;
RT "The Arabidopsis Mei2 homologue AML1 binds AtRaptor1B, the plant homologue
RT of a major regulator of eukaryotic cell growth.";
RL BMC Plant Biol. 5:2-2(2005).
RN [6]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=16473967; DOI=10.1105/tpc.105.039156;
RA Kaur J., Sebastian J., Siddiqi I.;
RT "The Arabidopsis-mei2-like genes play a role in meiosis and vegetative
RT growth in Arabidopsis.";
RL Plant Cell 18:545-559(2006).
CC -!- FUNCTION: Probable RNA-binding protein that plays a role in meiosis and
CC vegetative growth. {ECO:0000269|PubMed:15720729,
CC ECO:0000269|PubMed:16473967}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the embryo at the heart and torpedo
CC stages. {ECO:0000269|PubMed:15356386}.
CC -!- DISRUPTION PHENOTYPE: Early flowering. {ECO:0000269|PubMed:15720729}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAH57189.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305};
CC Sequence=CAB53653.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB53653.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=CAB78814.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB78814.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AL110123; CAB53653.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161548; CAB78814.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK319074; BAH57189.1; ALT_SEQ; mRNA.
DR PIR; T14812; T14812.
DR AlphaFoldDB; Q9SVV9; -.
DR SMR; Q9SVV9; -.
DR STRING; 3702.AT4G18120.1; -.
DR PaxDb; Q9SVV9; -.
DR PeptideAtlas; Q9SVV9; -.
DR PRIDE; Q9SVV9; -.
DR Araport; AT4G18120; -.
DR TAIR; locus:2117706; AT4G18120.
DR eggNOG; KOG4660; Eukaryota.
DR InParanoid; Q9SVV9; -.
DR PRO; PR:Q9SVV9; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q9SVV9; baseline and differential.
DR GO; GO:0016607; C:nuclear speck; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR GO; GO:0045927; P:positive regulation of growth; IMP:UniProtKB.
DR GO; GO:0045836; P:positive regulation of meiotic nuclear division; IMP:UniProtKB.
DR CDD; cd12524; RRM1_MEI2_like; 1.
DR CDD; cd12531; RRM3_MEI2_like; 1.
DR Gene3D; 3.30.70.330; -; 3.
DR InterPro; IPR034453; MEI2-like_RRM1.
DR InterPro; IPR034454; MEI2-like_RRM3.
DR InterPro; IPR007201; Mei2-like_Rrm_C.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR Pfam; PF00076; RRM_1; 2.
DR Pfam; PF04059; RRM_2; 1.
DR SMART; SM00360; RRM; 3.
DR SUPFAM; SSF54928; SSF54928; 2.
DR PROSITE; PS50102; RRM; 2.
PE 2: Evidence at transcript level;
KW Meiosis; Reference proteome; Repeat; RNA-binding.
FT CHAIN 1..759
FT /note="Protein MEI2-like 3"
FT /id="PRO_0000409343"
FT DOMAIN 166..239
FT /note="RRM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 251..324
FT /note="RRM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
SQ SEQUENCE 759 AA; 84571 MW; 6753FDB957DDEAC4 CRC64;
MNIPSGTFSR SDHFHASSDA SLFSSSLPLI QHQNINPRDS YHQSVDEMAS GLDHFSGGIG
NMLDDGDSHP IGNMLPDDEE ELFSGLMDDL NLSSLPATLD DLEDYDLFGS GGGLELETDP
YDSLNKGFSR MGFADSNVDN VMPQNIFQNG VGSIAGEHPY GEHPSRTLFV RNINSNVEDS
ELQALFEQYG HIRTLYTACK QRGFVMVSYN DIRASRAAMR ALQGKLLKKR KLDIHFSIPK
DNPSEKDVNQ GTLVVFNLAP SVSNRDLENI FGVYGEIKEI RETPNKRHHK FVEFFDVRSA
DAALKALNRT EIAGKRIKLE HSRPGGARRN MMLQMNPELE QDDSYSYLNH VESPLASSPI
GNWRNSPIDH PLQSFSKSPI FGNLSPTKNI RYPEFSMKTA SVNNDQEGRR FSHLDHLFSS
SSYNNASHKA STFQQPQSFG SVSSFGSLNS HPSHVETLSG SEFLWGSPSS SAWPVNPFSS
NRENHRFPYS AQNGSLHQLH HIGSAPSGFF PRSPETSSMG SVAFRGASGN MNAQRNLRET
SSPNFKMLSA PRRSQLFTGN GSYLWPAATM VSIDDPLEDG SNQQFDSNGN QADIKIQFQL
DLSKIMRGED PRTTLMIKNI PNKYTRNMLL AAIDEKNSGT YDFLYLPIDF KNKCNVGYAF
INMVSPKFTI ALYEAFNGKK WDKFNSEKVA SLAYARIQGK AALIAHFQNS SLMNEDRRCQ
PIVFDGSESK YPIIRENSQL EASNSTVSHP LVGENTHQS
