ID   AML4_ARATH              Reviewed;         907 AA.
AC   Q9LYN7;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 131.
DE   RecName: Full=Protein MEI2-like 4;
DE            Short=AML4;
DE   AltName: Full=MEI2-like protein 4;
GN   Name=ML4; OrderedLocusNames=At5g07290; ORFNames=T28J14.230;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130714; DOI=10.1038/35048507;
RA   Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA   Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA   Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA   Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA   Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA   O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA   Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA   Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA   Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA   Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA   Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA   Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA   Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA   Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA   Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA   Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA   McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA   Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA   Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA   Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA   Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA   Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA   Bevan M., Fransz P.F.;
RT   "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL   Nature 408:823-826(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA   Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA   Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA   Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA   Shinozaki K.;
RT   "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   GENE FAMILY, AND DEVELOPMENTAL STAGE.
RX   PubMed=15356386; DOI=10.1023/b:plan.0000040819.33383.b6;
RA   Anderson G.H., Alvarez N.D., Gilman C., Jeffares D.C., Trainor V.C.,
RA   Hanson M.R., Veit B.;
RT   "Diversification of genes encoding mei2 -like RNA binding proteins in
RT   plants.";
RL   Plant Mol. Biol. 54:653-670(2004).
RN   [5]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=15720729; DOI=10.1186/1471-2229-5-2;
RA   Anderson G.H., Hanson M.R.;
RT   "The Arabidopsis Mei2 homologue AML1 binds AtRaptor1B, the plant homologue
RT   of a major regulator of eukaryotic cell growth.";
RL   BMC Plant Biol. 5:2-2(2005).
RN   [6]
RP   FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=16473967; DOI=10.1105/tpc.105.039156;
RA   Kaur J., Sebastian J., Siddiqi I.;
RT   "The Arabidopsis-mei2-like genes play a role in meiosis and vegetative
RT   growth in Arabidopsis.";
RL   Plant Cell 18:545-559(2006).
CC   -!- FUNCTION: Probable RNA-binding protein that plays a role in meiosis and
CC       vegetative growth. {ECO:0000269|PubMed:15720729,
CC       ECO:0000269|PubMed:16473967}.
CC   -!- DEVELOPMENTAL STAGE: Expressed throughout the meristem during embryonic
CC       and vegetative development. Expressed in floral organogenic regions.
CC       {ECO:0000269|PubMed:15356386}.
CC   -!- DISRUPTION PHENOTYPE: Early flowering. {ECO:0000269|PubMed:15720729}.
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DR   EMBL; AL163652; CAB87285.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED91133.1; -; Genomic_DNA.
DR   EMBL; AK226960; BAE99028.1; -; mRNA.
DR   PIR; T48500; T48500.
DR   RefSeq; NP_196346.1; NM_120811.5.
DR   AlphaFoldDB; Q9LYN7; -.
DR   SMR; Q9LYN7; -.
DR   STRING; 3702.AT5G07290.1; -.
DR   iPTMnet; Q9LYN7; -.
DR   PaxDb; Q9LYN7; -.
DR   PRIDE; Q9LYN7; -.
DR   ProteomicsDB; 244402; -.
DR   EnsemblPlants; AT5G07290.1; AT5G07290.1; AT5G07290.
DR   GeneID; 830620; -.
DR   Gramene; AT5G07290.1; AT5G07290.1; AT5G07290.
DR   KEGG; ath:AT5G07290; -.
DR   Araport; AT5G07290; -.
DR   TAIR; locus:2182885; AT5G07290.
DR   eggNOG; KOG4660; Eukaryota.
DR   HOGENOM; CLU_012447_1_0_1; -.
DR   InParanoid; Q9LYN7; -.
DR   OMA; MHNSVGS; -.
DR   OrthoDB; 1464915at2759; -.
DR   PhylomeDB; Q9LYN7; -.
DR   PRO; PR:Q9LYN7; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q9LYN7; baseline and differential.
DR   Genevisible; Q9LYN7; AT.
DR   GO; GO:0003729; F:mRNA binding; IDA:TAIR.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0045927; P:positive regulation of growth; IMP:UniProtKB.
DR   GO; GO:0045836; P:positive regulation of meiotic nuclear division; IMP:UniProtKB.
DR   CDD; cd12524; RRM1_MEI2_like; 1.
DR   CDD; cd12531; RRM3_MEI2_like; 1.
DR   Gene3D; 3.30.70.330; -; 2.
DR   InterPro; IPR034453; MEI2-like_RRM1.
DR   InterPro; IPR034454; MEI2-like_RRM3.
DR   InterPro; IPR007201; Mei2-like_Rrm_C.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF00076; RRM_1; 2.
DR   Pfam; PF04059; RRM_2; 1.
DR   SMART; SM00360; RRM; 3.
DR   SUPFAM; SSF54928; SSF54928; 2.
DR   PROSITE; PS50102; RRM; 2.
PE   2: Evidence at transcript level;
KW   Meiosis; Reference proteome; Repeat; RNA-binding.
FT   CHAIN           1..907
FT                   /note="Protein MEI2-like 4"
FT                   /id="PRO_0000409344"
FT   DOMAIN          211..284
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          295..368
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          28..58
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          856..907
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        40..58
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        875..907
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   907 AA;  99890 MW;  EF124645671505D2 CRC64;
     MPSDILEPRG VPTPSHFHED IRITPEKQFG FMKNNPMPEG GVDRSSNLPT SSWTSDSYQL
     SQQSSLSGAL PSFIPNGRTT TNDTHWESSL FSSSLSDLFS RKLRLPRSDK LAFMSANREE
     EPSESLEEME AQTIGNLLPD EDDLFAEVVG EGVHKSRANG GDDLDDCDLF SSVGGMELDG
     DVFSSVSQRD GKRGSNVSTV AEHPQGEILS RILFVRNVDS SIEDCELGVL FKQFGDVRAL
     HTAGKNRGFI MVSYYDIRAA QKAARALHGR LLRGRKLDIR YSIPKENPKE NSSEGALWVN
     NLDSSISNEE LHGIFSSYGE IREVRRTMHE NSQVYIEFFD VRKAKVALQG LNGLEVAGRQ
     LKLAPTCPEG TSFWPQFASD DGEGGLPKMA FNNLSSAHMG RHFPGILAST SIDGGSIRGM
     HNSVGSPMNS FIERHQSLDV PIGLPPSARV ISASKPVGLQ EFGNPFDNSK TGIQSMPNLH
     PHFPDYLDNF ASGSPYKSST TFSEMVSDGQ KANEGFMMSN VRGVGVDGFN GGVIGSPINQ
     GSHRGNLNLW SNSNSQQHNQ SSGMMWPNSP SRVNGVPSQR IPPVTAFSRA SPLMVNMASS
     PVHHHIGSAP VLNSPFWDRR QAYVAESPES SGFHLGSPGS MGFPGSSPSH PMDFGSHKVF
     SHVGGNRMEA NSKNAVLRSS RQMPHLFTGR SPMLSVSGSF DLPNERYRNL SHRRSESNSS
     NAEKKLYELD VDRILRGEDS RTTLMIKNIP NKYTSKMLLA AIDEYCKGTY DFLYLPIDFK
     NKCNVGYAFI NLIEPENIVP FYKAFNGKKW EKFNSEKVAS LAYGRIQGKS ALIAHFQNSS
     LMNEDKRCRP ILFHTAGPNA GDQEPFPMGS NIRSRPGKHR TNSIENYTNF SSSSDNRDEP
     ANGNDSM