ID   AMN1_ASHGO              Reviewed;         392 AA.
AC   Q75A58;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Antagonist of mitotic exit network protein 1;
GN   Name=AMN1; OrderedLocusNames=ADR061C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Negative regulator of the mitotic exit network (MEN),
CC       required for multiple cell cycle checkpoints. Required for daughter
CC       cell separation and chromosome stability. Involved in copper
CC       sensitivity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P38285}. Nucleus
CC       {ECO:0000250|UniProtKB:P38285}.
CC   -!- SIMILARITY: Belongs to the AMN1 family. {ECO:0000305}.
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DR   EMBL; AE016817; AAS51981.1; -; Genomic_DNA.
DR   RefSeq; NP_984157.1; NM_209510.1.
DR   AlphaFoldDB; Q75A58; -.
DR   SMR; Q75A58; -.
DR   STRING; 33169.AAS51981; -.
DR   EnsemblFungi; AAS51981; AAS51981; AGOS_ADR061C.
DR   GeneID; 4620306; -.
DR   KEGG; ago:AGOS_ADR061C; -.
DR   eggNOG; KOG1947; Eukaryota.
DR   HOGENOM; CLU_031725_0_0_1; -.
DR   InParanoid; Q75A58; -.
DR   OMA; NCLLVNK; -.
DR   Proteomes; UP000000591; Chromosome IV.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   Gene3D; 3.80.10.10; -; 2.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF13516; LRR_6; 1.
DR   SMART; SM00367; LRR_CC; 5.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cytoplasm; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..392
FT                   /note="Antagonist of mitotic exit network protein 1"
FT                   /id="PRO_0000277841"
SQ   SEQUENCE   392 AA;  43239 MW;  BA92C4D1A99DBC56 CRC64;
     MSAEKSKIEH APWAWGLPVT PPRAAAACAA SPWTPRVPAD IAQAGGRAGT PRRRAPARTL
     GHVIFAVPEL VEQLVRFVAA GSEQAGAPRA LHHCLLVNRL WHAVTVAVLR ERLYFADARR
     LRQFAAAAHR GRLAPELVVL HKLTRLEQRD LDRALQHVSP ERLRRLELYV CPRVLPPAGY
     LGRAGGLRRL ALPGNKLVSD DFLIEACVHL PRLQVLDLRA CDRVSDAGVV AVATNCPRLH
     TVNLGRHRNG HLITSVAVVA LARHVQLETL GVAGCDVSDA GLWELAAVCG PSLARLSLNN
     CRYLTNRSVP ALLELNAFPN LSVLELRNIP HLTDVRAVVR YRQWKRACGL PVLVEGCDRL
     TQLFRCEERK LCKENCASPV RDLAAWLRSE ED