ID   AMN1_CANAL              Reviewed;         657 AA.
AC   Q5ALR8; A0A1D8PGI5;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2017, sequence version 2.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Antagonist of mitotic exit network protein 1;
GN   Name=AMN1; OrderedLocusNames=CAALFM_C201950CA;
GN   ORFNames=CaO19.1507, CaO19.9083;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Negative regulator of the mitotic exit network (MEN),
CC       required for multiple cell cycle checkpoints. Required for daughter
CC       cell separation and chromosome stability. Involved in copper
CC       sensitivity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P38285}. Nucleus
CC       {ECO:0000250|UniProtKB:P38285}.
CC   -!- SIMILARITY: Belongs to the AMN1 family. {ECO:0000305}.
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DR   EMBL; CP017624; AOW27237.1; -; Genomic_DNA.
DR   RefSeq; XP_722553.2; XM_717460.2.
DR   AlphaFoldDB; Q5ALR8; -.
DR   SMR; Q5ALR8; -.
DR   STRING; 237561.Q5ALR8; -.
DR   PRIDE; Q5ALR8; -.
DR   GeneID; 3635795; -.
DR   KEGG; cal:CAALFM_C201950CA; -.
DR   CGD; CAL0000192306; AMN1.
DR   VEuPathDB; FungiDB:C2_01950C_A; -.
DR   eggNOG; KOG1947; Eukaryota.
DR   HOGENOM; CLU_031725_0_0_1; -.
DR   InParanoid; Q5ALR8; -.
DR   OrthoDB; 1027299at2759; -.
DR   PRO; PR:Q5ALR8; -.
DR   Proteomes; UP000000559; Chromosome 2.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   Gene3D; 3.80.10.10; -; 2.
DR   InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   SMART; SM00367; LRR_CC; 3.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cytoplasm; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..657
FT                   /note="Antagonist of mitotic exit network protein 1"
FT                   /id="PRO_0000277842"
FT   REGION          57..140
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          262..282
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        91..140
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   657 AA;  75761 MW;  E62A22F2BDF53AC4 CRC64;
     MNFHSTKPLS YDSSDNEIYN PFLVSTNEEG RVSPTIDKQQ QPVLKRAKSI VSSNSLSAFF
     TDSKSKQQQQ QQQRDRKRNK DRRNRPGRLR RSHSTNSNDQ FIMNTGSFKL PDQDEFQFTM
     NNNSDNGFSS STSSSDLESV PDLTDDNIDE LTPETTPIKP VGNFYFNTLF DNEENTDGYY
     YKLNSQIKIR NELQQQQQQQ QQQRLTSSSP SIFEIPEIVY KIISYVDEQN TILPQESTPI
     RRNPLSYKHA LLIHGDKKSA QSALQKTTNQ QSQQNQQPSS VISSSPLYNC LLVNKLFYKI
     TSEIISTKFY SHNEQQLKKF IENKSHQQQN SSSPIIIQPK TFILHKLFQT KQIIFDQLIE
     FINFDQLSWF ELYMCPKISL DKPQSQTFMK IFQSCSNNLT KLIITGSKTI DDEFLMKLGQ
     FKCGDNLQIL DLRACELITD FGIYQLSLYC RNLTFINFGR KPISNGNGNG GGNGGSGRYI
     TDNSMIKLIN NNRKLSTIGL AGCHITDKCV WEIANKLPNI SRLSLNNCPK LTNSGINQIF
     TLTNTPNSNY FKCLSVLELR FNHQLTDLTS IIKFKRRQKF QFNIILLLEL CESLMLKYRQ
     QEFELDKLIS LKIFQDISHW VNDYNDNDGD LSYNEIKHLI NNNNNNNSSN NISTRGF