ID   AMN1_CANGA              Reviewed;         511 AA.
AC   Q6FRM1;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Antagonist of mitotic exit network protein 1;
GN   Name=AMN1; OrderedLocusNames=CAGL0H07491g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Negative regulator of the mitotic exit network (MEN),
CC       required for multiple cell cycle checkpoints. Required for daughter
CC       cell separation and chromosome stability. Involved in copper
CC       sensitivity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P38285}. Nucleus
CC       {ECO:0000250|UniProtKB:P38285}.
CC   -!- SIMILARITY: Belongs to the AMN1 family. {ECO:0000305}.
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DR   EMBL; CR380954; CAG60056.1; -; Genomic_DNA.
DR   RefSeq; XP_447123.1; XM_447123.1.
DR   AlphaFoldDB; Q6FRM1; -.
DR   SMR; Q6FRM1; -.
DR   STRING; 5478.XP_447123.1; -.
DR   EnsemblFungi; CAG60056; CAG60056; CAGL0H07491g.
DR   GeneID; 2888591; -.
DR   KEGG; cgr:CAGL0H07491g; -.
DR   CGD; CAL0131776; CAGL0H07491g.
DR   VEuPathDB; FungiDB:CAGL0H07491g; -.
DR   eggNOG; KOG1947; Eukaryota.
DR   HOGENOM; CLU_031725_1_0_1; -.
DR   InParanoid; Q6FRM1; -.
DR   OMA; NCLLVNK; -.
DR   Proteomes; UP000002428; Chromosome H.
DR   GO; GO:0005933; C:cellular bud; IEA:EnsemblFungi.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031267; F:small GTPase binding; IEA:EnsemblFungi.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007094; P:mitotic spindle assembly checkpoint signaling; IEA:EnsemblFungi.
DR   GO; GO:0031578; P:mitotic spindle orientation checkpoint signaling; IEA:EnsemblFungi.
DR   GO; GO:2001042; P:negative regulation of septum digestion after cytokinesis; IEA:EnsemblFungi.
DR   GO; GO:0032984; P:protein-containing complex disassembly; IEA:EnsemblFungi.
DR   GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IEA:EnsemblFungi.
DR   Gene3D; 3.80.10.10; -; 2.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF13516; LRR_6; 2.
DR   SMART; SM00367; LRR_CC; 5.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cytoplasm; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..511
FT                   /note="Antagonist of mitotic exit network protein 1"
FT                   /id="PRO_0000277843"
FT   REGION          27..58
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          99..119
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   511 AA;  58085 MW;  648056C6D07B325D CRC64;
     MVLPDSNIMK NGSIKRLRDS QIENSPYSRP IKKITPNSSH EDLSATISNE GSLNFTPRTS
     RQESLYNMKK IFQKTYSQTK LGLFSSKKQV NTLETAIPTT PKQQLPTPTT SPEKNNILWS
     TPNSLTSLRT ISNDLDDCRN RNLITDFSEL SIINSSSSSI YSTQQSHPIF EIPEIVDNIV
     KQLYLIENEQ DLLNGHHKKD VNRENTSTVV SCLAVSKTWN KVSKGYLMRD LKFTKSTSLT
     NFLSQCSTKK TTPQSLILHK MSDINNNNSR GLEIIIDPKQ LRHLEYYVCP NILPPVNWFQ
     SLTKLEKLIL PGNKLINDSY LIQICRYLPN LKVLDLRACD NITDAGIVAV GTHCKQLVSC
     NIGRHRNGSS ITGLSVVALA KNTMIRTLGL AGCDITDASM WELAQKCGKN IERLSLNNCN
     KLTNFSLPML FAFNYFPNLN VLEIQNIAKI TDVRHMVRYK IWKRSQRIPI LIKGCDRITK
     LIHEEERQIK AQSLKTARKD MTLWVNQLEN E