AMN1_HUMAN
ID AMN1_HUMAN Reviewed; 258 AA.
AC Q8IY45; B7Z7J3; Q6NVU4; Q86X98;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 29-MAY-2007, sequence version 4.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Protein AMN1 homolog;
GN Name=AMN1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBUNIT: Interacts with TASOR. {ECO:0000250|UniProtKB:B8JKV0}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8IY45-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8IY45-2; Sequence=VSP_054567;
CC -!- SIMILARITY: Belongs to the AMN1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH37897.3; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAH45831.2; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAH67906.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK302112; BAH13629.1; -; mRNA.
DR EMBL; AC023157; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471116; EAW88544.1; -; Genomic_DNA.
DR EMBL; BC037897; AAH37897.3; ALT_INIT; mRNA.
DR EMBL; BC045831; AAH45831.2; ALT_INIT; mRNA.
DR EMBL; BC067906; AAH67906.1; ALT_INIT; mRNA.
DR CCDS; CCDS44858.1; -. [Q8IY45-1]
DR CCDS; CCDS61089.1; -. [Q8IY45-2]
DR RefSeq; NP_001106873.1; NM_001113402.1. [Q8IY45-1]
DR RefSeq; NP_001265340.1; NM_001278411.1. [Q8IY45-2]
DR RefSeq; NP_001265341.1; NM_001278412.1. [Q8IY45-2]
DR RefSeq; XP_016874452.1; XM_017018963.1. [Q8IY45-2]
DR RefSeq; XP_016874453.1; XM_017018964.1. [Q8IY45-2]
DR RefSeq; XP_016874454.1; XM_017018965.1. [Q8IY45-2]
DR AlphaFoldDB; Q8IY45; -.
DR SMR; Q8IY45; -.
DR BioGRID; 128202; 5.
DR STRING; 9606.ENSP00000281471; -.
DR iPTMnet; Q8IY45; -.
DR PhosphoSitePlus; Q8IY45; -.
DR BioMuta; AMN1; -.
DR DMDM; 156630575; -.
DR EPD; Q8IY45; -.
DR jPOST; Q8IY45; -.
DR MassIVE; Q8IY45; -.
DR MaxQB; Q8IY45; -.
DR PaxDb; Q8IY45; -.
DR PeptideAtlas; Q8IY45; -.
DR PRIDE; Q8IY45; -.
DR ProteomicsDB; 6876; -.
DR ProteomicsDB; 71105; -. [Q8IY45-1]
DR Antibodypedia; 24696; 144 antibodies from 24 providers.
DR DNASU; 196394; -.
DR Ensembl; ENST00000281471.11; ENSP00000281471.6; ENSG00000151743.11. [Q8IY45-1]
DR Ensembl; ENST00000536761.5; ENSP00000440967.1; ENSG00000151743.11. [Q8IY45-2]
DR Ensembl; ENST00000537562.5; ENSP00000441419.1; ENSG00000151743.11. [Q8IY45-2]
DR GeneID; 196394; -.
DR KEGG; hsa:196394; -.
DR MANE-Select; ENST00000281471.11; ENSP00000281471.6; NM_001113402.2; NP_001106873.1.
DR UCSC; uc001rkq.4; human. [Q8IY45-1]
DR CTD; 196394; -.
DR DisGeNET; 196394; -.
DR GeneCards; AMN1; -.
DR HGNC; HGNC:27281; AMN1.
DR HPA; ENSG00000151743; Tissue enhanced (testis).
DR neXtProt; NX_Q8IY45; -.
DR OpenTargets; ENSG00000151743; -.
DR PharmGKB; PA162376371; -.
DR VEuPathDB; HostDB:ENSG00000151743; -.
DR eggNOG; KOG1947; Eukaryota.
DR GeneTree; ENSGT00730000111305; -.
DR HOGENOM; CLU_087966_0_0_1; -.
DR InParanoid; Q8IY45; -.
DR OMA; EVHMDHC; -.
DR OrthoDB; 1046098at2759; -.
DR PhylomeDB; Q8IY45; -.
DR TreeFam; TF331575; -.
DR PathwayCommons; Q8IY45; -.
DR BioGRID-ORCS; 196394; 11 hits in 1077 CRISPR screens.
DR ChiTaRS; AMN1; human.
DR GenomeRNAi; 196394; -.
DR Pharos; Q8IY45; Tbio.
DR PRO; PR:Q8IY45; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q8IY45; protein.
DR Bgee; ENSG00000151743; Expressed in cortical plate and 156 other tissues.
DR ExpressionAtlas; Q8IY45; baseline and differential.
DR Genevisible; Q8IY45; HS.
DR GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF13516; LRR_6; 3.
DR SMART; SM00367; LRR_CC; 6.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..258
FT /note="Protein AMN1 homolog"
FT /id="PRO_0000289273"
FT VAR_SEQ 1..18
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_054567"
SQ SEQUENCE 258 AA; 28408 MW; 845276D49BA6646B CRC64;
MPRPRRVSQL LDLCLWCFMK NISRYLTDIK PLPPNIKDRL IKIMSMQGQI TDSNISEILH
PEVQTLDLRS CDISDAALLH LSNCRKLKKL NLNASKGNRV SVTSEGIKAV ASSCSYLHEA
SLKRCCNLTD EGVVALALNC QLLKIIDLGG CLSITDVSLH ALGKNCPFLQ CVDFSATQVS
DSGVIALVSG PCAKKLEEIH MGHCVNLTDG AVEAVLTYCP QIRILLFHGC PLITDHSREV
LEQLVGPNKL KQVTWTVY
