ID   AMN1_KLULA              Reviewed;         424 AA.
AC   Q6CVS2;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Antagonist of mitotic exit network protein 1;
GN   Name=AMN1; OrderedLocusNames=KLLA0B09856g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Negative regulator of the mitotic exit network (MEN),
CC       required for multiple cell cycle checkpoints. Required for daughter
CC       cell separation and chromosome stability. Involved in copper
CC       sensitivity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P38285}. Nucleus
CC       {ECO:0000250|UniProtKB:P38285}.
CC   -!- SIMILARITY: Belongs to the AMN1 family. {ECO:0000305}.
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DR   EMBL; CR382122; CAH02360.1; -; Genomic_DNA.
DR   RefSeq; XP_451967.1; XM_451967.1.
DR   AlphaFoldDB; Q6CVS2; -.
DR   SMR; Q6CVS2; -.
DR   STRING; 28985.XP_451967.1; -.
DR   EnsemblFungi; CAH02360; CAH02360; KLLA0_B09856g.
DR   GeneID; 2897177; -.
DR   KEGG; kla:KLLA0_B09856g; -.
DR   eggNOG; KOG1947; Eukaryota.
DR   HOGENOM; CLU_647345_0_0_1; -.
DR   InParanoid; Q6CVS2; -.
DR   OMA; NCLLVNK; -.
DR   Proteomes; UP000000598; Chromosome B.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   Gene3D; 3.80.10.10; -; 2.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   SMART; SM00367; LRR_CC; 4.
DR   SUPFAM; SSF81383; SSF81383; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cytoplasm; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..424
FT                   /note="Antagonist of mitotic exit network protein 1"
FT                   /id="PRO_0000277845"
SQ   SEQUENCE   424 AA;  48352 MW;  C611DC086009CED1 CRC64;
     MSCVSSISSK RSRCEGFDDD FIHTPLKKCS KGYHEWSLSI TTPATTPTGK LDYKRKTKSL
     DDDLISSPVK FGTDANVLNA EFQELSLQKL LVSLSTSDDS KSNPIFHIPE LLHRIFNFLD
     HESLYRCSKV NPVWAAVASS IINKDLVIQQ SSISGDLKIV ELDQKVHPKS LTFYKLKQHR
     NFIENQLPRI RFTRLNSLNF YISPVLPAIF DDVTISNNLT KLTIAGNKKI NDEELISLIL
     GLPNLIDLDL RACSQISDIS IVSIVTHCPK LQSINLGRHE NSHLITDLSI MALSELEHLT
     TVGFSGCDKI SDVSIWQLYS KHSTTLVRLS INGCTQISDS SISDIVAKHG FPNLKVLDIR
     NCQLVRFKNL IQYRDWRHKY LMKPIHIHIS DSMKKEFELQ EQQLYKEFRT RIVNDLNRWV
     NEAT