ID   AMN1_OGAPD              Reviewed;         511 AA.
AC   Q8J2J3; E7R1T1; W1QIG3;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Antagonist of mitotic exit network protein 1;
GN   Name=AMN1; ORFNames=HPODL_00815;
OS   Ogataea parapolymorpha (strain ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL
OS   Y-7560 / DL-1) (Yeast) (Hansenula polymorpha).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Pichiaceae; Ogataea.
OX   NCBI_TaxID=871575;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL Y-7560 / DL-1;
RX   PubMed=12112240; DOI=10.1002/yea.881;
RA   Kim M.W., Agaphonov M.O., Kim J.Y., Rhee S.K., Kang H.A.;
RT   "Sequencing and functional analysis of the Hansenula polymorpha genomic
RT   fragment containing the YPT1 and PMI40 genes.";
RL   Yeast 19:863-871(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL Y-7560 / DL-1;
RX   PubMed=24279325; DOI=10.1186/1471-2164-14-837;
RA   Ravin N.V., Eldarov M.A., Kadnikov V.V., Beletsky A.V., Schneider J.,
RA   Mardanova E.S., Smekalova E.M., Zvereva M.I., Dontsova O.A., Mardanov A.V.,
RA   Skryabin K.G.;
RT   "Genome sequence and analysis of methylotrophic yeast Hansenula polymorpha
RT   DL1.";
RL   BMC Genomics 14:837-837(2013).
CC   -!- FUNCTION: Negative regulator of the mitotic exit network (MEN),
CC       required for multiple cell cycle checkpoints. Required for daughter
CC       cell separation and chromosome stability. Involved in copper
CC       sensitivity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P38285}. Nucleus
CC       {ECO:0000250|UniProtKB:P38285}.
CC   -!- SIMILARITY: Belongs to the AMN1 family. {ECO:0000305}.
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DR   EMBL; AF454544; AAN52528.1; -; Genomic_DNA.
DR   EMBL; AEOI02000005; ESX01421.1; -; Genomic_DNA.
DR   RefSeq; XP_013936255.1; XM_014080780.1.
DR   AlphaFoldDB; Q8J2J3; -.
DR   SMR; Q8J2J3; -.
DR   STRING; 1005962.Q8J2J3; -.
DR   EnsemblFungi; ESX01421; ESX01421; HPODL_00815.
DR   GeneID; 25770284; -.
DR   eggNOG; KOG1947; Eukaryota.
DR   HOGENOM; CLU_031725_0_0_1; -.
DR   OMA; NCLLVNK; -.
DR   OrthoDB; 1027299at2759; -.
DR   Proteomes; UP000008673; Chromosome III.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF13516; LRR_6; 2.
DR   SMART; SM00367; LRR_CC; 3.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cytoplasm; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..511
FT                   /note="Antagonist of mitotic exit network protein 1"
FT                   /id="PRO_0000277846"
FT   REGION          1..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        17..34
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   511 AA;  58087 MW;  C5CB3CC724B919C2 CRC64;
     MWDLAQQYPD TTPESSPLHE TRARERRSSL VDHRPLKRAS SLSFRIHTPC DYSSGASMTS
     CTSSTSLSSL GSLSSSARQL IMSRKTSPRH PTRLKTRFFS PFHSTNTSPV SPRLLETVEK
     LSIDNDAHPI FEIPEIVNLI LHYVGHDDRE RVPTEHAPVR KPPMSLNHAK LIHGEQGEKV
     WQRTLSTSST APPTGNLHNC LLVNKLWHSL TLEVLQENLY FDSDFKLMNY SPPRIAAPKS
     FVLHKLKSTQ QRDLANLHIN PVNLEWLEFY ICPKLLPSLH LYTAKLKKLV LPGSKVVDDV
     YLQQIAPLMP NLVHLDLRAC EHITDAGLYA IGTHCPKIET LNCGRHTKGI LVTDASISHI
     VANCNLKTLG VAGCGVSDAI LWSLAYQKGH QLERLSLNSC WRLTDAGISS VLMMDRFPRL
     AVLEIRRLTR LQQLRPIVEF KKRQMRRKIA VLVEACEELE ARLRAEERSL DLEISTRIFE
     DISEWLNGDD LQDQIEERNL QQFVQRRSVL V