AMO1_AMOLO
ID AMO1_AMOLO Reviewed; 62 AA.
AC C5H0C7;
DT 17-JUN-2020, integrated into UniProtKB/Swiss-Prot.
DT 28-JUL-2009, sequence version 1.
DT 25-MAY-2022, entry version 26.
DE RecName: Full=Amolopin-P1 {ECO:0000303|PubMed:18312859, ECO:0000312|EMBL:ACA09630.1};
DE Flags: Precursor;
OS Amolops loloensis (Lolokou Sucker Frog) (Staurois loloensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Amolops.
OX NCBI_TaxID=318551;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 45-62, FUNCTION, SYNTHESIS
RP OF 45-62, MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RC TISSUE=Skin, and Skin secretion;
RX PubMed=18312859; DOI=10.1016/j.biochi.2008.02.003;
RA Wang A., Wang J., Hong J., Feng H., Yang H., Yu X., Ma Y., Lai R.;
RT "A novel family of antimicrobial peptides from the skin of Amolops
RT loloensis.";
RL Biochimie 90:863-867(2008).
CC -!- FUNCTION: Antimicrobial peptide with activity against Gram-positive
CC bacteria (PubMed:18312859). Has been tested against S.aureus (MIC=37.5
CC ug/mL), against B.pumilus (MIC=75.0 ug/mL), B.cereus (no activity
CC detected) (PubMed:18312859). Does not show activity against Gram-
CC negative bacteria (E.coli, B.dysenteriae, A.calcoaceticus,
CC P.aeruginosa) and fungi (C.albicans) (PubMed:18312859). Does not show
CC hemolytic activity against rabbit erythrocytes (PubMed:18312859).
CC {ECO:0000269|PubMed:18312859}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:18312859}.
CC -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC {ECO:0000305|PubMed:18312859}.
CC -!- MASS SPECTROMETRY: Mass=1921.1; Method=FAB;
CC Evidence={ECO:0000269|PubMed:18312859};
CC -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC Amolopin subfamily. {ECO:0000305}.
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DR EMBL; EU311540; ACA09630.1; -; mRNA.
DR AlphaFoldDB; C5H0C7; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR InterPro; IPR004275; Frog_antimicrobial_propeptide.
DR Pfam; PF03032; FSAP_sig_propep; 1.
PE 1: Evidence at protein level;
KW Amphibian defense peptide; Antibiotic; Antimicrobial;
KW Cleavage on pair of basic residues; Direct protein sequencing; Immunity;
KW Innate immunity; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT PROPEP 23..44
FT /evidence="ECO:0000305|PubMed:18312859"
FT /id="PRO_0000450012"
FT PEPTIDE 45..62
FT /note="Amolopin-P1"
FT /evidence="ECO:0000269|PubMed:18312859"
FT /id="PRO_5002952490"
SQ SEQUENCE 62 AA; 6958 MW; 5AD718C3AFE3E153 CRC64;
MFPMKKSLLL LFFFGPISLS FCDQERGADE EENGGEVTEQ EVKRNILSSI VNGINRALSF
FG