ID   AMOA_AERHY              Reviewed;         396 AA.
AC   P23300;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1991, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Putative isochorismate synthase;
DE            EC=5.4.4.2;
DE   AltName: Full=Amonabactin;
DE   AltName: Full=Isochorismate mutase;
GN   Name=amoA;
OS   Aeromonas hydrophila.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Aeromonas.
OX   NCBI_TaxID=644;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=495A2;
RX   PubMed=1830579; DOI=10.1128/jb.173.16.5121-5128.1991;
RA   Barghouthi S., Payne S.M., Arceneaux J.E., Byers B.R.;
RT   "Cloning, mutagenesis, and nucleotide sequence of a siderophore
RT   biosynthetic gene (amoA) from Aeromonas hydrophila.";
RL   J. Bacteriol. 173:5121-5128(1991).
CC   -!- FUNCTION: Involved in the synthesis of amonabactin, a phenolate
CC       siderophore containing 2,3-dihydroxybenzoic acid (2,3-DHB).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=chorismate = isochorismate; Xref=Rhea:RHEA:18985,
CC         ChEBI:CHEBI:29748, ChEBI:CHEBI:29780; EC=5.4.4.2;
CC   -!- PATHWAY: Siderophore biosynthesis; amonabactin biosynthesis.
CC   -!- SIMILARITY: Belongs to the isochorismate synthase family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M63339; AAA21935.1; -; Genomic_DNA.
DR   PIR; A40365; A40365.
DR   AlphaFoldDB; P23300; -.
DR   SMR; P23300; -.
DR   UniPathway; UPA00015; -.
DR   GO; GO:0008909; F:isochorismate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR   GO; GO:1901576; P:organic substance biosynthetic process; IEA:UniProt.
DR   Gene3D; 3.60.120.10; -; 1.
DR   InterPro; IPR005801; ADC_synthase.
DR   InterPro; IPR015890; Chorismate_C.
DR   InterPro; IPR004561; IsoChor_synthase.
DR   Pfam; PF00425; Chorismate_bind; 1.
DR   SUPFAM; SSF56322; SSF56322; 1.
DR   TIGRFAMs; TIGR00543; isochor_syn; 1.
PE   3: Inferred from homology;
KW   Isomerase.
FT   CHAIN           1..396
FT                   /note="Putative isochorismate synthase"
FT                   /id="PRO_0000154143"
SQ   SEQUENCE   396 AA;  42074 MW;  5361F4C18EFAAE9D CRC64;
     MDTLVMENSA PAQAASSPEF LFTSGQGTLS ATDWASLITT PACEWPLLEQ QIASALAAAR
     PAGQANPLLI GCLRVRPGGS SCLYVPAAMS GDRPVPAAQA PVTAAMANQV VEANRVISVQ
     STPPASEFQA SVSAALDAFA QGRLAKVVLS RKLTLTLHQP ADPTQVMARL MAQNPHAFHF
     SLPLGQGRRL LGASPELLLR VSEGEVFTHP LARSARRASE PAQEQMVARD LLASRKDQHE
     HKLVIDEIRR VLTPHCRELA IPSSPSLMST DTLWHLGTPI AGRLNGGEAS VLSLACQLHP
     TPALCGYPTE LARQFIREQE PFRRALFSGI VGWCDSQGNG EWAVVIRCGV LDGHQVELFA
     GAGIVAGSDP PWSGPRPGTK LGTMLKALGL DLEVAQ