AMOL2_HUMAN
ID AMOL2_HUMAN Reviewed; 779 AA.
AC Q9Y2J4; A8K6F1; B7Z5Q1; E9PHW3; Q53EP1; Q96F99; Q9UKB4;
DT 27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 3.
DT 03-AUG-2022, entry version 166.
DE RecName: Full=Angiomotin-like protein 2;
DE AltName: Full=Leman coiled-coil protein;
DE Short=LCCP;
GN Name=AMOTL2; Synonyms=KIAA0989;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT ASP-731.
RC TISSUE=Brain;
RX PubMed=10231032; DOI=10.1093/dnares/6.1.63;
RA Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N.,
RA Tanaka A., Kotani H., Nomura N., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XIII. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 6:63-70(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4), AND VARIANT
RP ASP-731.
RC TISSUE=Placenta, and Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND VARIANT ASP-731.
RC TISSUE=Kidney;
RA Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 211-779 (ISOFORM 1), AND VARIANT ASP-731.
RC TISSUE=Glioblastoma;
RX PubMed=12406577; DOI=10.1016/s0378-1119(02)00928-9;
RA Bratt A., Wilson W.J., Troyanovsky B., Aase K., Kessler R., Van Meir E.G.,
RA Holmgren L.;
RT "Angiomotin belongs to a novel protein family with conserved coiled-coil
RT and PDZ binding domains.";
RL Gene 298:69-77(2002).
RN [5]
RP ERRATUM OF PUBMED:12406577.
RA Bratt A., Wilson W.J., Troyanovsky B., Aase K., Kessler R., Van Meir E.G.,
RA Holmgren L.;
RL Gene 310:231-231(2003).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 244-779 (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP FUNCTION, AND INTERACTION WITH SRC.
RX PubMed=17293535; DOI=10.1242/dev.02782;
RA Huang H., Lu F.I., Jia S., Meng S., Cao Y., Wang Y., Ma W., Yin K., Wen Z.,
RA Peng J., Thisse C., Thisse B., Meng A.;
RT "Amotl2 is essential for cell movements in zebrafish embryo and regulates
RT c-Src translocation.";
RL Development 134:979-988(2007).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [10]
RP FUNCTION.
RX PubMed=21937427; DOI=10.1074/jbc.m111.296806;
RA Wang Y., Li Z., Xu P., Huang L., Tong J., Huang H., Meng A.;
RT "Angiomotin-like2 gene (amotl2) is required for migration and proliferation
RT of endothelial cells during angiogenesis.";
RL J. Biol. Chem. 286:41095-41104(2011).
RN [11]
RP FUNCTION.
RX PubMed=22362771; DOI=10.1074/jbc.m112.347419;
RA Li Z., Wang Y., Zhang M., Xu P., Huang H., Wu D., Meng A.;
RT "The Amotl2 gene inhibits Wnt/beta-catenin signaling and regulates
RT embryonic development in zebrafish.";
RL J. Biol. Chem. 287:13005-13015(2012).
RN [12]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-759, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- FUNCTION: Regulates the translocation of phosphorylated SRC to
CC peripheral cell-matrix adhesion sites. Required for proper architecture
CC of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway,
CC probably by recruiting CTNNB1 to recycling endosomes and hence
CC preventing its translocation to the nucleus. Participates in
CC angiogenesis. May play a role in the polarity, proliferation and
CC migration of endothelial cells. Selectively promotes FGF-induced MAPK
CC activation through SRC. {ECO:0000269|PubMed:17293535,
CC ECO:0000269|PubMed:21937427, ECO:0000269|PubMed:22362771}.
CC -!- SUBUNIT: Interacts with SRC. {ECO:0000269|PubMed:17293535}.
CC -!- INTERACTION:
CC Q9Y2J4; A2BDD9: AMOT; NbExp=3; IntAct=EBI-746752, EBI-17286414;
CC Q9Y2J4; Q13515: BFSP2; NbExp=3; IntAct=EBI-746752, EBI-10229433;
CC Q9Y2J4; Q5PSV4: BRMS1L; NbExp=3; IntAct=EBI-746752, EBI-5666615;
CC Q9Y2J4; Q13895: BYSL; NbExp=3; IntAct=EBI-746752, EBI-358049;
CC Q9Y2J4; Q9H257-2: CARD9; NbExp=3; IntAct=EBI-746752, EBI-11530605;
CC Q9Y2J4; Q8N715: CCDC185; NbExp=3; IntAct=EBI-746752, EBI-740814;
CC Q9Y2J4; A0A1B0GWI1: CCDC196; NbExp=3; IntAct=EBI-746752, EBI-10181422;
CC Q9Y2J4; Q2TAC2-2: CCDC57; NbExp=3; IntAct=EBI-746752, EBI-10961624;
CC Q9Y2J4; Q8TD31-3: CCHCR1; NbExp=3; IntAct=EBI-746752, EBI-10175300;
CC Q9Y2J4; Q16543: CDC37; NbExp=3; IntAct=EBI-746752, EBI-295634;
CC Q9Y2J4; Q9BW66: CINP; NbExp=3; IntAct=EBI-746752, EBI-739784;
CC Q9Y2J4; Q9UER7: DAXX; NbExp=3; IntAct=EBI-746752, EBI-77321;
CC Q9Y2J4; O60941-5: DTNB; NbExp=3; IntAct=EBI-746752, EBI-11984733;
CC Q9Y2J4; Q8IYY4: DZIP1L; NbExp=3; IntAct=EBI-746752, EBI-10264440;
CC Q9Y2J4; Q86YD7: FAM90A1; NbExp=3; IntAct=EBI-746752, EBI-6658203;
CC Q9Y2J4; Q96RD9: FCRL5; NbExp=3; IntAct=EBI-746752, EBI-12091825;
CC Q9Y2J4; P46439: GSTM5; NbExp=4; IntAct=EBI-746752, EBI-4312072;
CC Q9Y2J4; Q9HAQ2: KIF9; NbExp=3; IntAct=EBI-746752, EBI-8472129;
CC Q9Y2J4; P04264: KRT1; NbExp=3; IntAct=EBI-746752, EBI-298429;
CC Q9Y2J4; Q969R5: L3MBTL2; NbExp=3; IntAct=EBI-746752, EBI-739909;
CC Q9Y2J4; Q03252: LMNB2; NbExp=3; IntAct=EBI-746752, EBI-2830427;
CC Q9Y2J4; Q8TAP4-4: LMO3; NbExp=3; IntAct=EBI-746752, EBI-11742507;
CC Q9Y2J4; Q96A72: MAGOHB; NbExp=4; IntAct=EBI-746752, EBI-746778;
CC Q9Y2J4; P55081: MFAP1; NbExp=3; IntAct=EBI-746752, EBI-1048159;
CC Q9Y2J4; Q15014: MORF4L2; NbExp=3; IntAct=EBI-746752, EBI-399257;
CC Q9Y2J4; Q9ULV0-2: MYO5B; NbExp=3; IntAct=EBI-746752, EBI-14093244;
CC Q9Y2J4; O14777: NDC80; NbExp=3; IntAct=EBI-746752, EBI-715849;
CC Q9Y2J4; P35240-4: NF2; NbExp=3; IntAct=EBI-746752, EBI-1014514;
CC Q9Y2J4; Q16649: NFIL3; NbExp=4; IntAct=EBI-746752, EBI-3951858;
CC Q9Y2J4; Q9Y5B8: NME7; NbExp=3; IntAct=EBI-746752, EBI-744782;
CC Q9Y2J4; Q4G0R1: PIBF1; NbExp=3; IntAct=EBI-746752, EBI-14066006;
CC Q9Y2J4; P54646: PRKAA2; NbExp=3; IntAct=EBI-746752, EBI-1383852;
CC Q9Y2J4; Q99633: PRPF18; NbExp=3; IntAct=EBI-746752, EBI-2798416;
CC Q9Y2J4; P17980: PSMC3; NbExp=5; IntAct=EBI-746752, EBI-359720;
CC Q9Y2J4; O75771: RAD51D; NbExp=8; IntAct=EBI-746752, EBI-1055693;
CC Q9Y2J4; Q15311: RALBP1; NbExp=3; IntAct=EBI-746752, EBI-749285;
CC Q9Y2J4; Q86YV0: RASAL3; NbExp=3; IntAct=EBI-746752, EBI-3437896;
CC Q9Y2J4; Q5VTR2: RNF20; NbExp=4; IntAct=EBI-746752, EBI-2372238;
CC Q9Y2J4; O75150: RNF40; NbExp=3; IntAct=EBI-746752, EBI-744408;
CC Q9Y2J4; O76064: RNF8; NbExp=3; IntAct=EBI-746752, EBI-373337;
CC Q9Y2J4; Q8TEC5: SH3RF2; NbExp=4; IntAct=EBI-746752, EBI-2130111;
CC Q9Y2J4; Q969G3: SMARCE1; NbExp=3; IntAct=EBI-746752, EBI-455078;
CC Q9Y2J4; O94964-4: SOGA1; NbExp=3; IntAct=EBI-746752, EBI-14083835;
CC Q9Y2J4; Q15560: TCEA2; NbExp=3; IntAct=EBI-746752, EBI-710310;
CC Q9Y2J4; P10827: THRA; NbExp=3; IntAct=EBI-746752, EBI-286285;
CC Q9Y2J4; Q3SY00: TSGA10IP; NbExp=3; IntAct=EBI-746752, EBI-10241197;
CC Q9Y2J4; P07947: YES1; NbExp=3; IntAct=EBI-746752, EBI-515331;
CC Q9Y2J4; Q05516: ZBTB16; NbExp=3; IntAct=EBI-746752, EBI-711925;
CC Q9Y2J4; A0A0S2Z6H0: ZGPAT; NbExp=3; IntAct=EBI-746752, EBI-16428984;
CC Q9Y2J4; Q8N5A5-2: ZGPAT; NbExp=3; IntAct=EBI-746752, EBI-10183064;
CC Q9Y2J4-4; Q9H2G9: BLZF1; NbExp=3; IntAct=EBI-10187270, EBI-2548012;
CC Q9Y2J4-4; Q5PSV4: BRMS1L; NbExp=3; IntAct=EBI-10187270, EBI-5666615;
CC Q9Y2J4-4; Q9H257: CARD9; NbExp=5; IntAct=EBI-10187270, EBI-751319;
CC Q9Y2J4-4; Q8TD31-3: CCHCR1; NbExp=3; IntAct=EBI-10187270, EBI-10175300;
CC Q9Y2J4-4; Q01850: CDR2; NbExp=3; IntAct=EBI-10187270, EBI-1181367;
CC Q9Y2J4-4; Q8WWE8: CYTH4; NbExp=3; IntAct=EBI-10187270, EBI-10277443;
CC Q9Y2J4-4; P35638-2: DDIT3; NbExp=3; IntAct=EBI-10187270, EBI-10173632;
CC Q9Y2J4-4; P63167: DYNLL1; NbExp=3; IntAct=EBI-10187270, EBI-349105;
CC Q9Y2J4-4; O60573: EIF4E2; NbExp=3; IntAct=EBI-10187270, EBI-398610;
CC Q9Y2J4-4; Q6P9G8: FAM184A; NbExp=3; IntAct=EBI-10187270, EBI-10253239;
CC Q9Y2J4-4; P63218: GNG5; NbExp=3; IntAct=EBI-10187270, EBI-10220734;
CC Q9Y2J4-4; Q08379: GOLGA2; NbExp=3; IntAct=EBI-10187270, EBI-618309;
CC Q9Y2J4-4; P46439: GSTM5; NbExp=3; IntAct=EBI-10187270, EBI-4312072;
CC Q9Y2J4-4; A1A4E9: KRT13; NbExp=3; IntAct=EBI-10187270, EBI-10171552;
CC Q9Y2J4-4; P19012: KRT15; NbExp=3; IntAct=EBI-10187270, EBI-739566;
CC Q9Y2J4-4; P08727: KRT19; NbExp=3; IntAct=EBI-10187270, EBI-742756;
CC Q9Y2J4-4; P35900: KRT20; NbExp=3; IntAct=EBI-10187270, EBI-742094;
CC Q9Y2J4-4; Q15323: KRT31; NbExp=3; IntAct=EBI-10187270, EBI-948001;
CC Q9Y2J4-4; O76015: KRT38; NbExp=3; IntAct=EBI-10187270, EBI-1047263;
CC Q9Y2J4-4; P60370: KRTAP10-5; NbExp=3; IntAct=EBI-10187270, EBI-10172150;
CC Q9Y2J4-4; Q9BYR5: KRTAP4-2; NbExp=3; IntAct=EBI-10187270, EBI-10172511;
CC Q9Y2J4-4; P61968: LMO4; NbExp=3; IntAct=EBI-10187270, EBI-2798728;
CC Q9Y2J4-4; Q1RN33: MAGEA4; NbExp=3; IntAct=EBI-10187270, EBI-10194128;
CC Q9Y2J4-4; P55081: MFAP1; NbExp=3; IntAct=EBI-10187270, EBI-1048159;
CC Q9Y2J4-4; Q9Y217: MTMR6; NbExp=3; IntAct=EBI-10187270, EBI-766064;
CC Q9Y2J4-4; Q9ULV0: MYO5B; NbExp=3; IntAct=EBI-10187270, EBI-311356;
CC Q9Y2J4-4; Q16649: NFIL3; NbExp=3; IntAct=EBI-10187270, EBI-3951858;
CC Q9Y2J4-4; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-10187270, EBI-741158;
CC Q9Y2J4-4; P17980: PSMC3; NbExp=5; IntAct=EBI-10187270, EBI-359720;
CC Q9Y2J4-4; O75771: RAD51D; NbExp=3; IntAct=EBI-10187270, EBI-1055693;
CC Q9Y2J4-4; Q15311: RALBP1; NbExp=3; IntAct=EBI-10187270, EBI-749285;
CC Q9Y2J4-4; Q8WWW0: RASSF5; NbExp=3; IntAct=EBI-10187270, EBI-367390;
CC Q9Y2J4-4; Q5VTR2: RNF20; NbExp=3; IntAct=EBI-10187270, EBI-2372238;
CC Q9Y2J4-4; O75150: RNF40; NbExp=3; IntAct=EBI-10187270, EBI-744408;
CC Q9Y2J4-4; Q08AM8: SH3RF2; NbExp=3; IntAct=EBI-10187270, EBI-10225873;
CC Q9Y2J4-4; Q969G3: SMARCE1; NbExp=3; IntAct=EBI-10187270, EBI-455078;
CC Q9Y2J4-4; P23497: SP100; NbExp=3; IntAct=EBI-10187270, EBI-751145;
CC Q9Y2J4-4; Q96R06: SPAG5; NbExp=3; IntAct=EBI-10187270, EBI-413317;
CC Q9Y2J4-4; P10827: THRA; NbExp=3; IntAct=EBI-10187270, EBI-286285;
CC Q9Y2J4-4; Q12933: TRAF2; NbExp=3; IntAct=EBI-10187270, EBI-355744;
CC Q9Y2J4-4; P14373: TRIM27; NbExp=3; IntAct=EBI-10187270, EBI-719493;
CC Q9Y2J4-4; O96006: ZBED1; NbExp=3; IntAct=EBI-10187270, EBI-740037;
CC Q9Y2J4-4; Q8N5A5: ZGPAT; NbExp=3; IntAct=EBI-10187270, EBI-3439227;
CC Q9Y2J4-4; Q8N5A5-2: ZGPAT; NbExp=3; IntAct=EBI-10187270, EBI-10183064;
CC -!- SUBCELLULAR LOCATION: Recycling endosome {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q9Y2J4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9Y2J4-2; Sequence=VSP_015711;
CC Name=3;
CC IsoId=Q9Y2J4-3; Sequence=VSP_037826;
CC Name=4;
CC IsoId=Q9Y2J4-4; Sequence=VSP_044081;
CC -!- PTM: Phosphorylation at Tyr-107 is necessary for efficient binding to
CC SRC and synergistically functioning with SRC to activate the downstream
CC MAPK pathway. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the angiomotin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH11454.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAA76833.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAD97318.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB023206; BAA76833.1; ALT_INIT; mRNA.
DR EMBL; AK291616; BAF84305.1; -; mRNA.
DR EMBL; AK299270; BAH12987.1; -; mRNA.
DR EMBL; AK223598; BAD97318.1; ALT_INIT; mRNA.
DR EMBL; AF175966; AAD56361.2; -; mRNA.
DR EMBL; AC010207; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC011454; AAH11454.1; ALT_INIT; mRNA.
DR CCDS; CCDS33860.1; -. [Q9Y2J4-2]
DR CCDS; CCDS63783.1; -. [Q9Y2J4-3]
DR CCDS; CCDS63784.1; -. [Q9Y2J4-4]
DR CCDS; CCDS87138.1; -. [Q9Y2J4-1]
DR RefSeq; NP_001265612.1; NM_001278683.1. [Q9Y2J4-4]
DR RefSeq; NP_001265614.1; NM_001278685.1. [Q9Y2J4-3]
DR RefSeq; NP_057285.3; NM_016201.3. [Q9Y2J4-2]
DR RefSeq; XP_006713717.1; XM_006713654.2. [Q9Y2J4-1]
DR RefSeq; XP_011511183.1; XM_011512881.1.
DR RefSeq; XP_016862069.1; XM_017006580.1. [Q9Y2J4-2]
DR RefSeq; XP_016862070.1; XM_017006581.1. [Q9Y2J4-2]
DR RefSeq; XP_016862071.1; XM_017006582.1. [Q9Y2J4-2]
DR AlphaFoldDB; Q9Y2J4; -.
DR SMR; Q9Y2J4; -.
DR BioGRID; 119530; 154.
DR CORUM; Q9Y2J4; -.
DR DIP; DIP-57510N; -.
DR IntAct; Q9Y2J4; 117.
DR MINT; Q9Y2J4; -.
DR STRING; 9606.ENSP00000424765; -.
DR GlyGen; Q9Y2J4; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q9Y2J4; -.
DR PhosphoSitePlus; Q9Y2J4; -.
DR BioMuta; AMOTL2; -.
DR DMDM; 308153633; -.
DR EPD; Q9Y2J4; -.
DR jPOST; Q9Y2J4; -.
DR MassIVE; Q9Y2J4; -.
DR MaxQB; Q9Y2J4; -.
DR PaxDb; Q9Y2J4; -.
DR PeptideAtlas; Q9Y2J4; -.
DR PRIDE; Q9Y2J4; -.
DR ProteomicsDB; 20614; -.
DR ProteomicsDB; 85814; -. [Q9Y2J4-1]
DR ProteomicsDB; 85815; -. [Q9Y2J4-2]
DR ProteomicsDB; 85816; -. [Q9Y2J4-3]
DR Antibodypedia; 33394; 108 antibodies from 22 providers.
DR DNASU; 51421; -.
DR Ensembl; ENST00000249883.10; ENSP00000249883.5; ENSG00000114019.15. [Q9Y2J4-2]
DR Ensembl; ENST00000422605.6; ENSP00000409999.2; ENSG00000114019.15. [Q9Y2J4-1]
DR Ensembl; ENST00000513145.1; ENSP00000425475.1; ENSG00000114019.15. [Q9Y2J4-3]
DR Ensembl; ENST00000514516.5; ENSP00000424765.1; ENSG00000114019.15. [Q9Y2J4-4]
DR GeneID; 51421; -.
DR KEGG; hsa:51421; -.
DR MANE-Select; ENST00000249883.10; ENSP00000249883.5; NM_016201.4; NP_057285.3. [Q9Y2J4-2]
DR UCSC; uc003eqf.4; human. [Q9Y2J4-1]
DR CTD; 51421; -.
DR DisGeNET; 51421; -.
DR GeneCards; AMOTL2; -.
DR HGNC; HGNC:17812; AMOTL2.
DR HPA; ENSG00000114019; Low tissue specificity.
DR MIM; 614658; gene.
DR neXtProt; NX_Q9Y2J4; -.
DR OpenTargets; ENSG00000114019; -.
DR PharmGKB; PA24775; -.
DR VEuPathDB; HostDB:ENSG00000114019; -.
DR eggNOG; ENOG502QR7W; Eukaryota.
DR GeneTree; ENSGT00940000156577; -.
DR HOGENOM; CLU_009937_2_0_1; -.
DR InParanoid; Q9Y2J4; -.
DR OMA; YRFYQPQ; -.
DR OrthoDB; 369983at2759; -.
DR PhylomeDB; Q9Y2J4; -.
DR TreeFam; TF333368; -.
DR PathwayCommons; Q9Y2J4; -.
DR Reactome; R-HSA-2028269; Signaling by Hippo.
DR SignaLink; Q9Y2J4; -.
DR BioGRID-ORCS; 51421; 26 hits in 1080 CRISPR screens.
DR ChiTaRS; AMOTL2; human.
DR GeneWiki; AMOTL2; -.
DR GenomeRNAi; 51421; -.
DR Pharos; Q9Y2J4; Tbio.
DR PRO; PR:Q9Y2J4; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q9Y2J4; protein.
DR Bgee; ENSG00000114019; Expressed in amniotic fluid and 202 other tissues.
DR ExpressionAtlas; Q9Y2J4; baseline and differential.
DR Genevisible; Q9Y2J4; HS.
DR GO; GO:0005923; C:bicellular tight junction; IBA:GO_Central.
DR GO; GO:0031410; C:cytoplasmic vesicle; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0055037; C:recycling endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0030036; P:actin cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0001525; P:angiogenesis; IBA:GO_Central.
DR GO; GO:0003365; P:establishment of cell polarity involved in ameboidal cell migration; IBA:GO_Central.
DR GO; GO:0030334; P:regulation of cell migration; IBA:GO_Central.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR InterPro; IPR009114; Angiomotin.
DR InterPro; IPR024646; Angiomotin_C.
DR Pfam; PF12240; Angiomotin_C; 1.
DR PRINTS; PR01807; ANGIOMOTIN.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Endosome; Phosphoprotein;
KW Reference proteome; Wnt signaling pathway.
FT CHAIN 1..779
FT /note="Angiomotin-like protein 2"
FT /id="PRO_0000190672"
FT REGION 41..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 263..308
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 522..543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 679..753
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 308..581
FT /evidence="ECO:0000255"
FT MOTIF 776..779
FT /note="PDZ-binding"
FT COMPBIAS 61..84
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..158
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..190
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 197..211
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 528..543
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 680..695
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 726..753
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 107
FT /note="Phosphotyrosine; by FGFR1"
FT /evidence="ECO:0000250"
FT MOD_RES 759
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 762
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8K371"
FT VAR_SEQ 1
FT /note="M -> MTGRKASGGTPCTLRKGAPIITLGKNWTERLAAGDSVGCSGARCHRP
FT LSRQLCASQRSM (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_044081"
FT VAR_SEQ 525..526
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|Ref.3"
FT /id="VSP_037826"
FT VAR_SEQ 701
FT /note="T -> TA (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10231032,
FT ECO:0000303|PubMed:14702039"
FT /id="VSP_015711"
FT VARIANT 227
FT /note="T -> I (in dbSNP:rs35377537)"
FT /id="VAR_055497"
FT VARIANT 342
FT /note="A -> P (in dbSNP:rs2303635)"
FT /id="VAR_055498"
FT VARIANT 415
FT /note="G -> S (in dbSNP:rs2241559)"
FT /id="VAR_055499"
FT VARIANT 731
FT /note="E -> D (in dbSNP:rs1353776)"
FT /evidence="ECO:0000269|PubMed:10231032,
FT ECO:0000269|PubMed:12406577, ECO:0000269|PubMed:14702039,
FT ECO:0000269|Ref.3"
FT /id="VAR_023535"
FT CONFLICT 666
FT /note="K -> E (in Ref. 2; BAH12987)"
FT /evidence="ECO:0000305"
FT CONFLICT 680
FT /note="Q -> K (in Ref. 4; AAD56361)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 779 AA; 85764 MW; 665BE69FD7757CEF CRC64;
MRTLEDSSGT VLHRLIQEQL RYGNLTETRT LLAIQQQALR GGAGTGGTGS PQASLEILAP
EDSQVLQQAT RQEPQGQEHQ GGENHLAENT LYRLCPQPSK GEELPTYEEA KAHSQYYAAQ
QAGTRPHAGD RDPRGAPGGS RRQDEALREL RHGHVRSLSE RLLQLSLERN GARAPSHMSS
SHSFPQLARN QQGPPLRGPP AEGPESRGPP PQYPHVVLAH ETTTAVTDPR YRARGSPHFQ
HAEVRILQAQ VPPVFLQQQQ QYQYLQQSQE HPPPPHPAAL GHGPLSSLSP PAVEGPVSAQ
ASSATSGSAH LAQMEAVLRE NARLQRDNER LQRELESSAE KAGRIEKLES EIQRLSEAHE
SLTRASSKRE ALEKTMRNKM DSEMRRLQDF NRDLRERLES ANRRLASKTQ EAQAGSQDMV
AKLLAQSYEQ QQEQEKLERE MALLRGAIED QRRRAELLEQ ALGNAQGRAA RAEEELRKKQ
AYVEKVERLQ QALGQLQAAC EKREQLELRL RTRLEQELKA LRAQQRQAGA PGGSSGSGGS
PELSALRLSE QLREKEEQIL ALEADMTKWE QKYLEERAMR QFAMDAAATA AAQRDTTLIR
HSPQPSPSSS FNEGLLTGGH RHQEMESRLK VLHAQILEKD AVIKVLQQRS RRDPGKAIQG
SLRPAKSVPS VFAAAAAGTQ GWQGLSSSER QTADAPARLT TDRAPTEEPV VTAPPAAHAK
HGSRDGSTQT EGPPDSTSTC LPPEPDSLLG CSSSQRAASL DSVATSRVQD LSDMVEILI
