ID   GLYCO_ABLVH             Reviewed;         526 AA.
AC   Q8JTH0;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 50.
DE   RecName: Full=Glycoprotein;
DE   Flags: Precursor;
GN   Name=G;
OS   Australian bat lyssavirus (isolate Human/AUS/1998) (ABLV).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Rhabdoviridae; Alpharhabdovirinae;
OC   Lyssavirus.
OX   NCBI_TaxID=446562;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9402; Pteropus alecto (Black flying fox).
OH   NCBI_TaxID=328804; Pteropus conspicillatus (Spectacled flying fox).
OH   NCBI_TaxID=9403; Pteropus poliocephalus (Grey-headed flying fox).
OH   NCBI_TaxID=94117; Pteropus scapulatus (Little red flying fox).
OH   NCBI_TaxID=446909; Saccolaimus.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=12083841; DOI=10.1006/viro.2002.1417;
RA   Warrilow D., Smith I.L., Harrower B., Smith G.A.;
RT   "Sequence analysis of an isolate from a fatal human infection of Australian
RT   bat lyssavirus.";
RL   Virology 297:109-119(2002).
CC   -!- FUNCTION: Attaches the virus to host cellular receptor, inducing
CC       endocytosis of the virion. In the endosome, the acidic pH induces
CC       conformational changes in the glycoprotein trimer, which trigger fusion
CC       between virus and cell membrane. There is convincing in vitro evidence
CC       that the muscular form of the nicotinic acetylcholine receptor (nAChR),
CC       the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin
CC       receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus
CC       entry into cells (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homotrimer. Interacts with matrix protein (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- PTM: Glycosylated and palmitoylated by host. Glycosylation is crucial
CC       for glycoprotein export at the cell surface (By similarity).
CC       {ECO:0000250}.
CC   -!- BIOTECHNOLOGY: Primary surface antigen capable of inducing and reacting
CC       with virus-neutralizing antibodies. Almost all human and veterinary
CC       vaccines are based on the functional aspects of the G protein.
CC   -!- MISCELLANEOUS: Arg-352 is highly involved in rabies virus
CC       pathogenicity. Its mutation dramatically attenuates the virus (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the lyssavirus glycoprotein family.
CC       {ECO:0000305}.
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DR   EMBL; AF418014; AAN05309.1; -; Genomic_RNA.
DR   SMR; Q8JTH0; -.
DR   Proteomes; UP000006884; Genome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR001903; Rhabd_glycop.
DR   Pfam; PF00974; Rhabdo_glycop; 1.
PE   1: Evidence at protein level;
KW   Glycoprotein; Lipoprotein; Membrane; Palmitate; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix; Viral envelope protein; Virion.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..526
FT                   /note="Glycoprotein"
FT                   /id="PRO_0000295793"
FT   TOPO_DOM        20..459
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        460..480
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        481..526
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000255"
FT   LIPID           480
FT                   /note="S-palmitoyl cysteine; by host"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        338
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   526 AA;  59372 MW;  C64BC70B07C0D0C9 CRC64;
     MLLQIVLLMS LMVFSPCPGK FPLYTIPDKL GPWSPIDIHH LSCPNNLIVE DEGCTSLSGF
     SYMELKVGFI TTIKVSGFTC TGVVTESETY TNFFGYVTTT FKRKHFRPTP EFCRNAYNWK
     VAGDPRYEES LHNPYPDYHW LRTVTTTKES LLIISPSVVD MDPYDKSLHS KMFPKGTCSG
     ASVPSIFCST NHDYTLWMPE NPKPGMSCDI FTTSKGKKAS KGGKVCGFVD ERGLYKSLKG
     ACKLKLCGIS GLRLMDGSWV SIQNHEEAKW CSPDQLVNIH DFHSDEIEHL IVEELVRKRE
     ECLDALESIM TTKSVSFRRL SHLRKLVPGF GKAYTIVNKT LMEADAHYKS VRTWNEIIPS
     KGCLKVRERC HPPYNGVFFN GIILSPDGHV LIPEMQSSLL QQHVELLESS VIPLIHPLAD
     PSTVFKRDDE AEDFIEVHLP DVQKQVSGID LGLSEWERYL IIGASAVVLF ALAIIFAVCC
     RRCKRRKKAR TDRIELDRKV SVTSQSGKVI PSWESYKIEA GGHFRS