ID   GLYCO_BEFVB             Reviewed;         623 AA.
AC   P32595; Q77N36;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 1.
DT   29-SEP-2021, entry version 90.
DE   RecName: Full=Glycoprotein;
DE   Flags: Precursor;
GN   Name=G;
OS   Bovine ephemeral fever virus (strain BB7721) (BEFV).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Rhabdoviridae; Alpharhabdovirinae;
OC   Ephemerovirus.
OX   NCBI_TaxID=928297;
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
OH   NCBI_TaxID=89462; Bubalus bubalis (Domestic water buffalo).
OH   NCBI_TaxID=58271; Culicoides.
OH   NCBI_TaxID=9970; Syncerus caffer (African buffalo).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA], AND PARTIAL PROTEIN SEQUENCE.
RX   PubMed=1413521; DOI=10.1016/0042-6822(92)90165-l;
RA   Walker P.J., Byrne K.A., Riding G.A., Cowley J.A., Wang Y., McWilliam S.;
RT   "The genome of bovine ephemeral fever rhabdovirus contains two related
RT   glycoprotein genes.";
RL   Virology 191:49-61(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=8046391; DOI=10.1099/0022-1317-75-8-1889;
RA   Walker P.J., Wang Y., Cowley J.A., McWilliam S.M., Prehaud C.J.;
RT   "Structural and antigenic analysis of the nucleoprotein of bovine ephemeral
RT   fever rhabdovirus.";
RL   J. Gen. Virol. 75:1889-1899(1994).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=11074128; DOI=10.1016/s0168-1702(00)00215-x;
RA   Dhillon J., Cowley J.A., Wang Y., Walker P.J.;
RT   "RNA polymerase (L) gene and genome terminal sequences of ephemeroviruses
RT   bovine ephemeral fever virus and Adelaide River virus indicate a close
RT   relationship to vesiculoviruses.";
RL   Virus Res. 70:87-95(2000).
CC   -!- FUNCTION: Attaches the virus to host cellular receptors, inducing
CC       endocytosis of the virion. The acidic pH of the endosome induces
CC       conformational changes in the glycoprotein trimer which trigger fusion
CC       between the virus and the cell membrane (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homotrimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000250}; Single-pass type I
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the rhabdoviruses glycoprotein family.
CC       {ECO:0000305}.
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DR   EMBL; M94266; AAA42760.1; -; Genomic_RNA.
DR   EMBL; AF234533; AAG10413.1; -; Genomic_DNA.
DR   PIR; A44060; VGVNBE.
DR   RefSeq; NP_065402.1; NC_002526.1.
DR   GeneID; 911729; -.
DR   KEGG; vg:911729; -.
DR   Proteomes; UP000008588; Genome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR001903; Rhabd_glycop.
DR   Pfam; PF00974; Rhabdo_glycop; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Glycoprotein; Host-virus interaction; Membrane;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix;
KW   Viral attachment to host cell; Viral envelope protein; Virion;
KW   Virus entry into host cell.
FT   SIGNAL          1..12
FT                   /evidence="ECO:0000255"
FT   CHAIN           13..623
FT                   /note="Glycoprotein"
FT                   /id="PRO_0000040988"
FT   TOPO_DOM        13..539
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        540..554
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        555..623
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        175
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        264
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        416
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        438
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        507
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   623 AA;  72284 MW;  B2837A4609E1502C CRC64;
     MFKVLIITLL VNKIHLEKIY NVPVNCGELH PVKAHEIKCP QRLNELSLQA HHNLAKDEHY
     NKICRPQLKD DAHLEGFICR KQRWITKCSE TWYFSTSIEY QILEVIPEYS GCTDAVKKLD
     QGALIPPYYP PAGCFWNTEM NQEIEFYVLI QHKPFLNPYD NLIYDSRFLT PCTINDSKTK
     GCPLKDITGT WIPDVRVEEI SEHCNNKHWE CITVKSFRSE LNDKERLWEA PDIGLVHVNK
     GCLSTFCGKN GIIFEDGEWW SIENQTESDF QNFKIEKCKG KKPGFRMHTD RTEFEELDIK
     AELEHERCLN TISKILNKEN INTLDMSYLA PTRPGRDYAY LFEQTSWQEK LCLSLPDSGR
     VSKDCNIDWR TSTRGGMVKK NHYGIGSYKR AWCEYRPFVD KNEDGYIDIQ ELNGHNMSGN
     HAILETAPAG GSSGNRLNVT LNGMIFVEPT KLYLHTKSLY EGIEDYQKLI KFEVMEYDNV
     EENLIRYEED EKFKPVNLNP HEKSQINRTD IVREIQKGGK KVLSAVVGWF TSTAKAVRWT
     IWAVGAIVTT YAIYKLYKMV KSNSSHSKHR EADLEGLQST TKENMRVEKN DKNYQDLELG
     LYEEIRSIKG GSKQTGDDRF FDH