GLYCO_CHAV
ID GLYCO_CHAV Reviewed; 530 AA.
AC P13180; Q5IX87; Q5IX88; Q5IX89; Q5IX90; Q5IX91; Q5IX92; Q5IX93; Q6TYA0;
DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT 29-MAY-2007, sequence version 2.
DT 29-SEP-2021, entry version 104.
DE RecName: Full=Glycoprotein;
DE Flags: Precursor;
GN Name=G;
OS Chandipura virus (strain I653514) (CHPV).
OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC Monjiviricetes; Mononegavirales; Rhabdoviridae; Alpharhabdovirinae;
OC Vesiculovirus.
OX NCBI_TaxID=11273;
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=7198; Phlebotominae (sandflies).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=2741347; DOI=10.1016/0042-6822(89)90540-0;
RA Masters P.S., Bhella R.S., Butcher M., Patel B., Ghosh H.P., Banerjee A.K.;
RT "Structure and expression of the glycoprotein gene of Chandipura virus.";
RL Virology 171:285-290(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=Isolate CIN0318R, Isolate CIN0327M, Isolate CIN0327R,
RC Isolate CIN0331M, Isolate CIN0360R, Isolate CIN0360V, and Isolate CIN6514V;
RX PubMed=15705335; DOI=10.3201/eid1101.040602;
RA Arankalle V.A., Prabhakar S.S., Madhukar W.A., Hanumaih X.,
RA Dattatraya P.S., Akhilesh Chandra M.;
RT "G, N, and P gene-based analysis of Chandipura viruses, India.";
RL Emerg. Infect. Dis. 11:123-126(2005).
CC -!- FUNCTION: Attaches the virus to host cellular receptor, inducing
CC endocytosis of the virion. In the endosome, the acidic pH induces
CC conformational changes in the glycoprotein trimer, which trigger fusion
CC between virus and cell membrane (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homotrimers. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}.
CC -!- PTM: Glycosylated by host. Palmitoylated by host on Cys-498 (By
CC similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the vesiculovirus glycoprotein family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA42916.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; J04350; AAA42916.1; ALT_FRAME; Genomic_RNA.
DR EMBL; AY382603; AAR26234.1; -; Genomic_RNA.
DR EMBL; AY614717; AAU81933.1; -; Genomic_RNA.
DR EMBL; AY614718; AAU81934.1; -; Genomic_RNA.
DR EMBL; AY614719; AAU81935.1; -; Genomic_RNA.
DR EMBL; AY614720; AAU81936.1; -; Genomic_RNA.
DR EMBL; AY614721; AAU81937.1; -; Genomic_RNA.
DR EMBL; AY614722; AAU81938.1; -; Genomic_RNA.
DR EMBL; AY614723; AAU81939.1; -; Genomic_RNA.
DR PIR; A32443; VGVNCV.
DR PDB; 4D6W; X-ray; 3.60 A; A/B/C=22-440.
DR PDB; 5MDM; X-ray; 3.00 A; A/C/E/F=22-440.
DR PDBsum; 4D6W; -.
DR PDBsum; 5MDM; -.
DR SMR; P13180; -.
DR ABCD; P13180; 1 sequenced antibody.
DR Proteomes; UP000008448; Genome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR InterPro; IPR001903; Rhabd_glycop.
DR Pfam; PF00974; Rhabdo_glycop; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Disulfide bond; Glycoprotein; Host-virus interaction;
KW Lipoprotein; Membrane; Palmitate; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix; Viral attachment to host cell;
KW Viral envelope protein; Virion; Virus entry into host cell.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..530
FT /note="Glycoprotein"
FT /id="PRO_0000040990"
FT TOPO_DOM 22..473
FT /note="Virion surface"
FT /evidence="ECO:0000255"
FT TRANSMEM 474..494
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 495..530
FT /note="Intravirion"
FT /evidence="ECO:0000255"
FT LIPID 498
FT /note="S-palmitoyl cysteine; by host"
FT /evidence="ECO:0000250"
FT CARBOHYD 184
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 344
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT DISULFID 45..308
FT /evidence="ECO:0000250"
FT DISULFID 80..113
FT /evidence="ECO:0000250"
FT DISULFID 89..135
FT /evidence="ECO:0000250"
FT DISULFID 174..179
FT /evidence="ECO:0000250"
FT DISULFID 199..244
FT /evidence="ECO:0000250"
FT DISULFID 239..277
FT /evidence="ECO:0000250"
FT VARIANT 16
FT /note="I -> V (in strain: Isolate CIN0360R and Isolate
FT CIN0360V)"
FT VARIANT 19
FT /note="L -> S (in strain: Isolate CIN0309R, Isolate
FT CIN0318R, Isolate CIN0327M, Isolate CIN0327R, Isolate
FT CIN0331M, Isolate CIN0360R and Isolate CIN0360V)"
FT VARIANT 22
FT /note="Y -> S (in strain: Isolate CIN0309R, Isolate
FT CIN0318R,in Isolate CIN0327M, Isolate CIN0327R, Isolate
FT CIN0331M, Isolate CIN0360R and Isolate CIN0360V)"
FT VARIANT 30
FT /note="N -> S (in strain: Isolate CIN0360R and Isolate
FT CIN0360V)"
FT VARIANT 40
FT /note="K -> R (in strain: Isolate CIN0327M and Isolate
FT CIN0327R)"
FT VARIANT 128
FT /note="L -> P (in strain: Isolate CIN0309R, Isolate
FT CIN0318R, Isolate CIN0327M, Isolate CIN0327R, Isolate
FT CIN0331M, Isolate CIN0360R, Isolate CIN0360V and Isolate
FT CIN6514V)"
FT VARIANT 213
FT /note="D -> V (in strain: Isolate CIN0309R, Isolate
FT CIN0360R and Isolate CIN0360V)"
FT VARIANT 219
FT /note="A -> T (in strain: Isolate CIN6514V)"
FT VARIANT 222
FT /note="G -> A (in strain: Isolate CIN0309R, Isolate
FT CIN0318R, Isolate CIN0327M, Isolate CIN0327R, Isolate
FT CIN0331M, Isolate CIN0360R and Isolate CIN0360V)"
FT VARIANT 264
FT /note="R -> K (in strain: Isolate CIN0309R, Isolate
FT CIN0318R, Isolate CIN0327M, Isolate CIN0327R, Isolate
FT CIN0331M, Isolate CIN0360R and Isolate CIN0360V)"
FT VARIANT 269
FT /note="H -> P (in strain: Isolate CIN0309R, Isolate
FT CIN0318R, Isolate CIN0327M, Isolate CIN0327R,n Isolate
FT CIN0331M, Isolate CIN0360R and Isolate CIN0360V)"
FT VARIANT 367
FT /note="P -> M (in strain: Isolate CIN0309R, Isolate
FT CIN0318R, Isolate CIN0327M, Isolate CIN0327R and Isolate
FT CIN0331M)"
FT VARIANT 424
FT /note="L -> V (in strain: Isolate CIN0327M and Isolate
FT CIN0327R)"
FT VARIANT 502
FT /note="R -> K (in strain: Isolate CIN0360R and Isolate
FT CIN0360V)"
FT STRAND 23..31
FT /evidence="ECO:0007829|PDB:5MDM"
FT HELIX 49..51
FT /evidence="ECO:0007829|PDB:5MDM"
FT STRAND 57..70
FT /evidence="ECO:0007829|PDB:5MDM"
FT HELIX 72..75
FT /evidence="ECO:0007829|PDB:5MDM"
FT STRAND 77..90
FT /evidence="ECO:0007829|PDB:5MDM"
FT STRAND 93..96
FT /evidence="ECO:0007829|PDB:5MDM"
FT STRAND 98..106
FT /evidence="ECO:0007829|PDB:5MDM"
FT HELIX 110..121
FT /evidence="ECO:0007829|PDB:5MDM"
FT STRAND 137..139
FT /evidence="ECO:0007829|PDB:5MDM"
FT STRAND 141..152
FT /evidence="ECO:0007829|PDB:5MDM"
FT STRAND 156..158
FT /evidence="ECO:0007829|PDB:5MDM"
FT TURN 159..162
FT /evidence="ECO:0007829|PDB:5MDM"
FT STRAND 163..165
FT /evidence="ECO:0007829|PDB:5MDM"
FT STRAND 172..174
FT /evidence="ECO:0007829|PDB:5MDM"
FT STRAND 176..191
FT /evidence="ECO:0007829|PDB:5MDM"
FT STRAND 200..216
FT /evidence="ECO:0007829|PDB:5MDM"
FT HELIX 220..222
FT /evidence="ECO:0007829|PDB:5MDM"
FT STRAND 223..226
FT /evidence="ECO:0007829|PDB:5MDM"
FT STRAND 232..234
FT /evidence="ECO:0007829|PDB:5MDM"
FT HELIX 235..237
FT /evidence="ECO:0007829|PDB:5MDM"
FT STRAND 239..243
FT /evidence="ECO:0007829|PDB:5MDM"
FT STRAND 246..250
FT /evidence="ECO:0007829|PDB:5MDM"
FT STRAND 254..258
FT /evidence="ECO:0007829|PDB:5MDM"
FT STRAND 268..270
FT /evidence="ECO:0007829|PDB:5MDM"
FT HELIX 271..273
FT /evidence="ECO:0007829|PDB:5MDM"
FT HELIX 287..289
FT /evidence="ECO:0007829|PDB:5MDM"
FT HELIX 291..316
FT /evidence="ECO:0007829|PDB:5MDM"
FT HELIX 323..327
FT /evidence="ECO:0007829|PDB:5MDM"
FT STRAND 332..343
FT /evidence="ECO:0007829|PDB:5MDM"
FT STRAND 346..360
FT /evidence="ECO:0007829|PDB:5MDM"
FT STRAND 362..372
FT /evidence="ECO:0007829|PDB:5MDM"
FT STRAND 378..380
FT /evidence="ECO:0007829|PDB:5MDM"
FT STRAND 386..388
FT /evidence="ECO:0007829|PDB:5MDM"
FT STRAND 391..393
FT /evidence="ECO:0007829|PDB:5MDM"
FT HELIX 395..397
FT /evidence="ECO:0007829|PDB:5MDM"
FT STRAND 399..401
FT /evidence="ECO:0007829|PDB:5MDM"
FT STRAND 404..406
FT /evidence="ECO:0007829|PDB:5MDM"
FT HELIX 409..411
FT /evidence="ECO:0007829|PDB:5MDM"
FT STRAND 413..419
FT /evidence="ECO:0007829|PDB:5MDM"
FT HELIX 422..425
FT /evidence="ECO:0007829|PDB:5MDM"
SQ SEQUENCE 530 AA; 59185 MW; B684F42AEB43BA84 CRC64;
MTSSVTISVV LLISFITPLY SYLSIAFPEN TKLDWKPVTK NTRYCPMGGE WFLEPGLQEE
SFLSSTPIGA TPSKSDGFLC HAAKWVTTCD FRWYGPKYIT HSIHNIKPTR SDCDTALASY
KSGTLVSLGF PPESCGYASV TDSEFLVIMI TPHHVGVDDY RGHWVDPLFV GGECDQSYCD
TIHNSSVWIP ADQTKKNICG QSFTPLTVTV AYDKTKEIAA GGIVFKSKYH SHMEGARTCR
LSYCGRNGIK FPNGEWVSLD VKTRIQEKHL LPLFKECPAG TEVRSTLQSD GAQVLTSEIQ
RILDYSLCQN TWDKVERKEP LSPLDLSYLA SKSPGKGLAY TVINGTLSFA HTRYVRMWID
GPVLKEPKGK RESPSGISSD IWTQWFKYGD MEIGPNGLLK TAGGYKFPWH LIGMGIVDNE
LHELSEANPL DHPQLPHAQS IADDSEEIFF GDTGVSKNPV ELVTGWFTSW KESLAAGVVL
ILVVVLIYGV LRCFPVLCTT CRKPKWKKGV ERSDSFEMRI FKPNNMRARV
