ID   GLYCO_HIRRV             Reviewed;         508 AA.
AC   Q77SK0; Q76G52; Q82020;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   29-SEP-2021, entry version 66.
DE   RecName: Full=Glycoprotein;
DE   Flags: Precursor;
GN   Name=G;
OS   Hirame rhabdovirus (strain Korea/CA 9703/1997) (HIRRV).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Rhabdoviridae; Gammarhabdovirinae;
OC   Novirhabdovirus.
OX   NCBI_TaxID=453457;
OH   NCBI_TaxID=72011; Acanthopagrus schlegelii (Black porgy).
OH   NCBI_TaxID=8255; Paralichthys olivaceus (Bastard halibut) (Hippoglossus olivaceus).
OH   NCBI_TaxID=61084; Plecoglossus altivelis (Ayu).
OH   NCBI_TaxID=160818; Sebastes inermis (Dark-banded rockfish).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=Isolate 8401H;
RX   PubMed=8806175; DOI=10.1016/0168-1702(96)01300-7;
RA   Bjorklund H.V., Higman K.H., Kurath G.;
RT   "The glycoprotein genes and gene junctions of the fish rhabdoviruses spring
RT   viremia of carp virus and hirame rhabdovirus: analysis of relationships
RT   with other rhabdoviruses.";
RL   Virus Res. 42:65-80(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=Isolate 8601H;
RX   PubMed=15312663; DOI=10.1016/j.fsi.2004.04.012;
RA   Takano T., Iwahori A., Hirono I., Aoki T.;
RT   "Development of a DNA vaccine against hirame rhabdovirus and analysis of
RT   the expression of immune-related genes after vaccination.";
RL   Fish Shellfish Immunol. 17:367-374(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=15567027; DOI=10.1016/j.virusres.2004.06.004;
RA   Kim D.H., Oh H.K., Eou J.I., Seo H.J., Kim S.K., Oh M.J., Nam S.W.,
RA   Choi T.J.;
RT   "Complete nucleotide sequence of the hirame rhabdovirus, a pathogen of
RT   marine fish.";
RL   Virus Res. 107:1-9(2005).
CC   -!- FUNCTION: Attaches the virus to host cellular receptor, inducing
CC       endocytosis of the virion. In the endosome, the acidic pH induces
CC       conformational changes in the glycoprotein trimer, which trigger fusion
CC       between virus and cell membrane (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homotrimer. Interacts with matrix protein (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000250}; Single-pass type I
CC       membrane protein {ECO:0000250}.
CC   -!- PTM: Glycosylated by host. Glycosylation is crucial for glycoprotein
CC       export at the cell surface (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the novirhabdovirus glycoprotein family.
CC       {ECO:0000305}.
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DR   EMBL; U24073; AAB39502.1; -; Genomic_RNA.
DR   EMBL; AB103462; BAC81968.1; -; Genomic_RNA.
DR   EMBL; AF104985; AAQ73460.1; -; Genomic_RNA.
DR   Proteomes; UP000008118; Genome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR   InterPro; IPR001903; Rhabd_glycop.
DR   InterPro; IPR002417; Spike_prot.
DR   Pfam; PF00974; Rhabdo_glycop; 1.
DR   PRINTS; PR00796; SPIKEPROTEIN.
PE   3: Inferred from homology;
KW   Glycoprotein; Host-virus interaction; Membrane; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix; Viral attachment to host cell;
KW   Viral envelope protein; Virion; Virus entry into host cell.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..508
FT                   /note="Glycoprotein"
FT                   /id="PRO_0000299233"
FT   TOPO_DOM        21..461
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        462..482
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        483..508
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000255"
FT   VARIANT         71
FT                   /note="R -> Q (in strain: Isolate 8401H and Isolate 8601H)"
FT   VARIANT         217
FT                   /note="S -> P (in strain: Isolate 8601H)"
FT   VARIANT         245
FT                   /note="L -> P (in strain: Isolate 8401H and Isolate 8601H)"
SQ   SEQUENCE   508 AA;  56602 MW;  27B777D44C7D0E0D CRC64;
     MDPRIMYYTV LLTTAARVYG QTIKPGVDSV SDQPTWANPL FTYPVDCPAA KLSKVSPSQL
     RCPRIFDDEN RGLVAYPAVI RSLSVGNNLG DIHTQGEYVH KVLYRTTCST GFFGGQTIEK
     ALVEMKLAPR EVGVYDTTTA SALYFPAPRC QWYTDNVHND LTFYYTTAKS VLRDPYTLGF
     LDSDFIEGKC SKSPCQTHWS NVVWKGDSGV AACDTGSEIK GHIFVDKTSH HVVKATSYGH
     HPWGLHRACM ITFCGKPWIR TDLGDLIAIE YNGGATLLAF PACKDTTVGM RGSLDDFAYL
     DDLVKSSESR EECLEAHAEI IATNSVTPYL LSKFRSPHPG INDVYAMHDG SIYHGKCMTV
     AIDEVSKDRR TYRAHQTSAF VAWGHPFGDE WGGFHGLHGN DTPVIPDLEK YVAQYKVSMM
     DKMDIRPVPH PSVQILYNDT DTADITIRKI DSFDLQSLNW SFWPSLSALG GVPILLALVF
     FLYCCMNRRP SMPAAPQEIP MYHLASRG