ID   GLYCO_IHNVW             Reviewed;         508 AA.
AC   Q82683;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   29-SEP-2021, entry version 76.
DE   RecName: Full=Glycoprotein;
DE   AltName: Full=Spike glycoprotein;
DE   Flags: Precursor;
GN   Name=G;
OS   Infectious hematopoietic necrosis virus (strain WRAC) (IHNV).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Rhabdoviridae; Gammarhabdovirinae;
OC   Novirhabdovirus.
OX   NCBI_TaxID=429314;
OH   NCBI_TaxID=8028; Salmo.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=8578857; DOI=10.1016/0168-1702(95)00056-v;
RA   Morzunov S.P., Winton J.R., Nichol S.T.;
RT   "The complete genome structure and phylogenetic relationship of infectious
RT   hematopoietic necrosis virus.";
RL   Virus Res. 38:175-192(1995).
CC   -!- FUNCTION: Binds to specific receptor at cellular surface, bringing
CC       about the attachment of the virus particle to the cell. Plays a major
CC       role in the determination of host range restriction and virulence.
CC       Class I viral fusion protein. Responsible for penetration of the viral
CC       nucleocapsid into the cell cytoplasm by mediating the fusion of the
CC       membrane of the endocytosed virus particle with the endosomal membrane.
CC       Low pH in endosomes induce an irreversible conformational change in G,
CC       releasing a fusion hydrophobic peptide (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homotrimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000250}; Single-pass type I
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the novirhabdovirus glycoprotein family.
CC       {ECO:0000305}.
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DR   EMBL; L40883; AAC42153.1; -; Genomic_RNA.
DR   RefSeq; NP_042679.1; NC_001652.1.
DR   GeneID; 1489848; -.
DR   KEGG; vg:1489848; -.
DR   Proteomes; UP000007212; Genome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR   InterPro; IPR001903; Rhabd_glycop.
DR   InterPro; IPR002417; Spike_prot.
DR   Pfam; PF00974; Rhabdo_glycop; 1.
DR   PRINTS; PR00796; SPIKEPROTEIN.
PE   3: Inferred from homology;
KW   Glycoprotein; Host-virus interaction; Membrane; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix; Viral attachment to host cell;
KW   Viral envelope protein; Virion; Virus entry into host cell.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..508
FT                   /note="Glycoprotein"
FT                   /id="PRO_0000282900"
FT   TOPO_DOM        21..461
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        462..482
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        483..508
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        56
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        400
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        401
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        438
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   508 AA;  56755 MW;  14E2A706463F3B50 CRC64;
     MDTMITTPLI LILITCGANS QTVKPDTASE SDQPTWSNPL FTYPEGCTLD KLSKVNASQL
     RCPRIFDDEN RGLIAYPTSI RSLSVGNDLG DIHTQGNHIH KVLYRTICST GFFGGQTIEK
     ALVKMKLSTK EAGAYDTTTA AALYFPAPRC QWYTDNVQND LIFYYTTQKS VLRDPYTRDF
     LDSDFIGGKC TKSPCQTHWS NVVWMGDAGI PACDSSQEIK AHLFVDKISN RVVKATSYGH
     HPWGLHQACM IEFCGQQWIR TDLGDLISVV YNSGSEILSF PKCEDKTVGM RGNLDDFAYL
     DDLVKASESR EECLEAHAEI ISTNSVTPYL LSKFRSPHPG INDVYAMHKG SIYHGMCMTV
     AVDEVSKDRT TYRAHRATSF TKWERPFGDE WEGFHGLHGN NTTIIPDLEK YVAQYKMSMM
     EPMSIKSVPH PSILALYNET DVSGISIRKL DSFDLQSLHW SFWPTISALG GIPFVLLLAV
     AACCCWSGRP PTPSVPQSIP MYHLANRS