ID   GLYCO_ISFV              Reviewed;         523 AA.
AC   Q5K2K4;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Glycoprotein;
DE   Flags: Precursor;
GN   Name=G;
OS   Isfahan virus (ISFV).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Rhabdoviridae; Alpharhabdovirinae;
OC   Vesiculovirus.
OX   NCBI_TaxID=290008;
OH   NCBI_TaxID=10045; Gerbillinae (gerbils).
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=29031; Phlebotomus papatasi (Sandfly).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=15614433; DOI=10.1007/s00705-004-0452-2;
RA   Marriott A.C.;
RT   "Complete genome sequences of Chandipura and Isfahan vesiculoviruses.";
RL   Arch. Virol. 150:671-680(2005).
CC   -!- FUNCTION: Attaches the virus to host cellular receptor, inducing
CC       endocytosis of the virion. In the endosome, the acidic pH induces
CC       conformational changes in the glycoprotein trimer, which trigger fusion
CC       between virus and cell membrane (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homotrimers. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000250}; Single-pass type I
CC       membrane protein {ECO:0000250}.
CC   -!- PTM: Glycosylated by host. Palmitoylated by host on Cys-497 (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the vesiculovirus glycoprotein family.
CC       {ECO:0000305}.
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DR   EMBL; AJ810084; CAH17547.1; -; Genomic_RNA.
DR   RefSeq; YP_007641385.1; NC_020806.1.
DR   SMR; Q5K2K4; -.
DR   GeneID; 14857915; -.
DR   KEGG; vg:14857915; -.
DR   Proteomes; UP000204017; Genome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR   InterPro; IPR001903; Rhabd_glycop.
DR   Pfam; PF00974; Rhabdo_glycop; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Glycoprotein; Host-virus interaction; Lipoprotein;
KW   Membrane; Palmitate; Signal; Transmembrane; Transmembrane helix;
KW   Viral attachment to host cell; Viral envelope protein; Virion;
KW   Virus entry into host cell.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..523
FT                   /note="Glycoprotein"
FT                   /id="PRO_0000287247"
FT   TOPO_DOM        21..475
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        476..496
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        497..523
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000255"
FT   LIPID           497
FT                   /note="S-palmitoyl cysteine; by host"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        183
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        343
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   DISULFID        44..307
FT                   /evidence="ECO:0000250"
FT   DISULFID        79..112
FT                   /evidence="ECO:0000250"
FT   DISULFID        88..134
FT                   /evidence="ECO:0000250"
FT   DISULFID        173..178
FT                   /evidence="ECO:0000250"
FT   DISULFID        198..243
FT                   /evidence="ECO:0000250"
FT   DISULFID        238..276
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   523 AA;  58343 MW;  E1D68DC6B54C0522 CRC64;
     MTSVLFMVGV LLGAFGSTHC SIQIVFPSET KLVWKPVLKG TRYCPQSAEL NLEPDLKTMA
     FDSKVPIGIT PSNSDGYLCH AAKWVTTCDF RWYGPKYITH SVHSLRPTVS DCKAAVEAYN
     AGTLMYPGFP PESCGYASIT DSEFYVMLVT PHPVGVDDYR GHWVDPLFPT SECNSNFCET
     VHNATMWIPK DLKTHDVCSQ DFQTIRVSVM YPQTKPTKGA DLTLKSKFHA HMKGDRVCKM
     KFCNKNGLRL GNGEWIEVGD EVMLDNSKLL SLFPDCLVGS VVKSTLLSEG VQTALWETDR
     LLDYSLCQNT WEKIDRKEPL SAVDLSYLAP RSPGKGMAYI VANGSLMSAP ARYIRVWIDS
     PILKEIKGKK ESASGIDTVL WEQWLPFNGM ELGPNGLIKT KSGYKFPLYL LGMGIVDQDL
     QELSSVNPVD HPHVPIAQAF VSEGEEVFFG DTGVSKNPIE LISGWFSDWK ETAAALGFAA
     ISVILIIGLM RLLPLLCRRR KQKKVIYKDV ELNSFDPRQA FHR