ID   GLYCO_PIRYV             Reviewed;         529 AA.
AC   Q85213;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   29-SEP-2021, entry version 78.
DE   RecName: Full=Glycoprotein;
DE   Flags: Precursor;
GN   Name=G;
OS   Piry virus (PIRYV).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Rhabdoviridae; Alpharhabdovirinae;
OC   Vesiculovirus.
OX   NCBI_TaxID=11274;
OH   NCBI_TaxID=126289; Gracilinanus microtarsus (Brazilian gracile mouse opossum).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=1454546; DOI=10.1093/nar/20.21.5843;
RA   Barik S.;
RT   "The phosphoprotein (P) gene of the rhabdovirus Piry: its cloning,
RT   sequencing, and expression in Escherichia coli.";
RL   Nucleic Acids Res. 20:5843-5843(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=8724858; DOI=10.1159/000150451;
RA   Brun G., Bao X., Prevec L.;
RT   "The relationship of Piry virus to other vesiculoviruses: a re-evaluation
RT   based on the glycoprotein gene sequence.";
RL   Intervirology 38:274-282(1995).
CC   -!- FUNCTION: Attaches the virus to host cellular receptor, inducing
CC       endocytosis of the virion. In the endosome, the acidic pH induces
CC       conformational changes in the glycoprotein trimer, which trigger fusion
CC       between virus and cell membrane (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homotrimers. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000250}; Single-pass type I
CC       membrane protein {ECO:0000250}.
CC   -!- PTM: Glycosylated by host. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the vesiculovirus glycoprotein family.
CC       {ECO:0000305}.
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DR   EMBL; D26175; BAA05163.1; -; Genomic_RNA.
DR   SMR; Q85213; -.
DR   PRIDE; Q85213; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR   InterPro; IPR001903; Rhabd_glycop.
DR   Pfam; PF00974; Rhabdo_glycop; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Glycoprotein; Host-virus interaction; Lipoprotein;
KW   Membrane; Palmitate; Signal; Transmembrane; Transmembrane helix;
KW   Viral attachment to host cell; Viral envelope protein; Virion;
KW   Virus entry into host cell.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..529
FT                   /note="Glycoprotein"
FT                   /id="PRO_0000287248"
FT   TOPO_DOM        19..469
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        470..490
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        491..529
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        181
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        340
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   DISULFID        42..304
FT                   /evidence="ECO:0000250"
FT   DISULFID        77..110
FT                   /evidence="ECO:0000250"
FT   DISULFID        86..132
FT                   /evidence="ECO:0000250"
FT   DISULFID        171..176
FT                   /evidence="ECO:0000250"
FT   DISULFID        195..240
FT                   /evidence="ECO:0000250"
FT   DISULFID        235..273
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   529 AA;  59771 MW;  9343868D5B67CA9F CRC64;
     MDLFPILVVV LMTDTVLGKF QIVFPDQNEL EWRPVVGDSR HCPQSSEMQF DGSRSQTILT
     GKAPVGITPS KSDGFICHAA KWVTTCDFRW YGPKYITHSI HHLRPTTSDC ETALQRYKDG
     SLINLGFPPE SCGYATVTDS EAMLVQVTPH HVGVDDYRGH WIDPLFPGGE CSTNFCDTVH
     NSSVWIPKSQ KTDICAQSFK NIKMTASYPS EGALVSDRFA FHSAYHPNMP GSTVCIMDFC
     EQKGLRFTNG EWMGLNVEQS IREKKISAIF PNCVAGTEIR ATLESEGART LTWETQRMLD
     YSLCQNTWDK VSRKEPLSPL DLSYLSPRAP GKGMAYTVIN GTLHSAHAKY IRTWIDYGEM
     KEIKGGRGEY SKAPELLWSQ WFDFGPFKIG PNGLLHTGKT FKFPLYLIGA GIIDEDLHEL
     DEAAPIDHPQ MPDAKSVLPE DEEIFFGDTG VSKNPIELIQ GWFSNWRESV MAIVGIVLLI
     VVTFLAIKTV RVLNCLWRPR KKRIVRQEVD VESRLNHFEM RGFPEYVKR