ID   GLYL_BOVIN              Reviewed;          49 AA.
AC   P59760;
DT   27-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT   27-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 41.
DE   RecName: Full=Glycolactin;
DE            EC=3.1.27.-;
DE   Flags: Fragments;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   PROTEIN SEQUENCE, AND CHARACTERIZATION.
RC   TISSUE=Milk;
RX   PubMed=10486275; DOI=10.1006/bbrc.1999.1091;
RA   Ye X.Y., Cheng K.J., Ng T.B.;
RT   "Isolation and characterization of angiogenin-1 and a novel protein
RT   designated lactogenin from bovine milk.";
RL   Biochem. Biophys. Res. Commun. 263:187-191(1999).
RN   [2]
RP   INHIBITION OF HIV-1 REVERSE TRANSCRIPTASE.
RX   PubMed=11105990; DOI=10.1016/s0024-3205(00)00853-5;
RA   Wang H., Ye X.Y., Ng T.B.;
RT   "First demonstration of an inhibitory activity of milk proteins against
RT   human immunodeficiency virus-1 reverse transcriptase and the effect of
RT   succinylation.";
RL   Life Sci. 67:2745-2752(2000).
CC   -!- FUNCTION: Manifests poly C-specific RNase activity toward yeast tRNA,
CC       elicits a dose-dependent inhibition of cell-free translation, inhibits
CC       formation of superoxide ions in vitro and inhibits the hemagglutinating
CC       activities of soybean lectin and Ricinus communis agglutinin 120.
CC       Inhibits HIV-1 reverse transcriptase.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Milk.
CC   -!- PTM: Glycosylated.
CC   -!- SIMILARITY: Belongs to the pancreatic ribonuclease family.
CC       {ECO:0000305}.
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DR   AlphaFoldDB; P59760; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016209; F:antioxidant activity; IEA:UniProtKB-KW.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   GO; GO:0017148; P:negative regulation of translation; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Antioxidant; Antiviral defense; Direct protein sequencing; Endonuclease;
KW   Glycoprotein; Hydrolase; Nuclease; Protein synthesis inhibitor;
KW   Reference proteome; Secreted.
FT   CHAIN           1..>49
FT                   /note="Glycolactin"
FT                   /id="PRO_0000057217"
FT   NON_CONS        29..30
FT                   /evidence="ECO:0000305"
FT   NON_CONS        39..40
FT                   /evidence="ECO:0000305"
FT   NON_TER         49
SQ   SEQUENCE   49 AA;  5574 MW;  FCE3D8F37092E44C CRC64;
     SALYALYDFS PPARKMRAYT VRAYVHGSYS RRGPWYDFEP VPGASMDGL