ID   AMP1_CHICK              Reviewed;          39 AA.
AC   P80389;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Antimicrobial peptide CHP1;
DE   AltName: Full=Chicken heterophil peptide 1;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=7964174; DOI=10.1002/jlb.56.5.661;
RA   Evans E.W., Beach G.G., Wunderlich J., Harmon B.G.;
RT   "Isolation of antimicrobial peptides from avian heterophils.";
RL   J. Leukoc. Biol. 56:661-665(1994).
CC   -!- FUNCTION: Bactericidal activity; inhibits S.aureus and E.coli.
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DR   AlphaFoldDB; P80389; -.
DR   SMR; P80389; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR001855; Defensin_beta-typ.
DR   Pfam; PF00711; Defensin_beta; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Direct protein sequencing; Disulfide bond;
KW   Reference proteome.
FT   PEPTIDE         1..39
FT                   /note="Antimicrobial peptide CHP1"
FT                   /id="PRO_0000044771"
FT   DISULFID        6..28
FT                   /evidence="ECO:0000250"
FT   DISULFID        13..34
FT                   /evidence="ECO:0000250"
FT   DISULFID        18..35
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   39 AA;  4480 MW;  5DDF1051693D254E CRC64;
     GRKSDCFRKS GFCAFLKCPS LTLISGKCSR FYLCCKRIR