ID   AMP1_MELGA              Reviewed;          65 AA.
AC   P80391;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-1998, sequence version 2.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Antimicrobial peptide THP1;
DE   AltName: Full=Turkey heterophil peptide 1;
DE   Flags: Precursor;
OS   Meleagris gallopavo (Wild turkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Meleagridinae; Meleagris.
OX   NCBI_TaxID=9103;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Bone marrow;
RX   PubMed=9745666; DOI=10.1046/j.1365-2052.1998.00338.x;
RA   Brockus C.W., Harmon B.G., Jackwood M.W.;
RT   "Characterization of beta-defensin prepropeptide mRNA from chicken and
RT   turkey bone marrow.";
RL   Anim. Genet. 29:283-289(1998).
RN   [2]
RP   PROTEIN SEQUENCE OF 26-60.
RX   PubMed=7964174; DOI=10.1002/jlb.56.5.661;
RA   Evans E.W., Beach G.G., Wunderlich J., Harmon B.G.;
RT   "Isolation of antimicrobial peptides from avian heterophils.";
RL   J. Leukoc. Biol. 56:661-665(1994).
CC   -!- FUNCTION: Bactericidal activity; inhibits S.aureus and E.coli.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; AF033337; AAC36053.1; -; mRNA.
DR   AlphaFoldDB; P80391; -.
DR   SMR; P80391; -.
DR   Ensembl; ENSMGAT00000032643; ENSMGAP00000025020; ENSMGAG00000021529.
DR   GeneTree; ENSGT01030000235503; -.
DR   Proteomes; UP000001645; Chromosome 2.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR001855; Defensin_beta-typ.
DR   Pfam; PF00711; Defensin_beta; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Defensin; Direct protein sequencing;
KW   Disulfide bond; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000269|PubMed:7964174"
FT   PEPTIDE         26..60
FT                   /note="Antimicrobial peptide THP1"
FT                   /id="PRO_0000007016"
FT   PROPEP          61..65
FT                   /id="PRO_0000007017"
FT   DISULFID        31..53
FT                   /evidence="ECO:0000250"
FT   DISULFID        38..59
FT                   /evidence="ECO:0000250"
FT   DISULFID        43..60
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   65 AA;  7086 MW;  9237FC0F7B448D45 CRC64;
     MRIVYLLFPF ILLLAQGAAG SSLALGKREK CLRRNGFCAF LKCPTLSVIS GTCSRFQVCC
     KTLLG